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| 1 | Implementation of a polling protocol for predicting celiac disease in videocapsule analysis显示文摘AIM: To investigate the presence of small intestinal villous atrophy in celiac disease patients from quantitative analysis of videocapsule image sequences.METHODS: Nine celiac patient data with biopsy-proven villous atrophy and seven control patient data lacking villous atrophy were used for analysis. Celiacs had biopsy-proven disease with scores of Marsh Ⅱ-Ⅲ C except in the case of one hemophiliac patient. At four small intestinal levels (duodenal bulb, distal duodenum, jejunum, and ileum), video clips of length 200 frames (100 s) were analyzed. Twenty-four measurements were used for image characterization. These measurements were determined by quantitatively processing the videocapsule images via techniques for texture analysis, motility estimation, volumetric reconstruction using shape-from-shading principles, and image transformation. Each automated measurement method, or automaton, was polled as to whether or not villous atrophy was present in the small intestine, indicating celiac disease. Each automaton's vote was determined based upon an optimized parameter threshold level, with the threshold levels being determined from prior data. A prediction of villous atrophy was made if it received the majority of votes (≥ 13), while no prediction was made for tie votes (12-12). Thus each set of images was classified as being from either a celiac disease patient or from a control patient. RESULTS: Separated by intestinal level, the overall sensitivity of automata polling for predicting villous atrophy and hence celiac disease was 83.9%, while the specificity was 92.9%, and the overall accuracy of automata-based polling was 88.1%. The method of image transformation yielded the highest sensitivity at 93.8%, while the method of texture analysis using subbands had the highest specificity at 76.0%. Similar results of prediction were observed at all four small intestinal locations, but there were more tie votes at location 4 (ileum). Incorrect prediction which reduced sensitivity occurred for two celiac patients with Marsh type Ⅱ pattern, which is characterized by crypt hyperplasia, but normal villous architecture. Pooled from all levels, there was a mean of 14.31 ± 3.28 automaton votes for celiac vs 9.67 ± 3.31 automaton votes for control when celiac patient data was analyzed (P<0.001). Pooled from all levels, there was a mean of 9.71 ± 2.8128 automaton votes for celiac vs 14.32 ± 2.7931 automaton votes for control when control patient data was analyzed (P<0.001). CONCLUSION: Automata-based polling may be useful to indicate presence of mucosal atrophy, indicative of celiac disease, across the entire small bowel, though this must be confirmed in a larger patient set. Since the method is quantitative and automated, it can potentially eliminate observer bias and enable the detectionof subtle abnormality in patients lacking a clear diagnosis. Our paradigm was found to be more efficacious at proximal small intestinal locations, which may suggest a greater presence and severity of villous atrophy at proximal as compared with distal locations. | Edward J Ciaccio Christina A Tennyson Govind Bhagat Suzanne K Lewis Peter H Green | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 3 |
| 2 | Beta-7 integrin controls enterocyte migration in the small intestine显示文摘AIM:To hypothesize that beta-7 integrin affects cellularmigration of both,lymphocytes and enterocytes.METHODS:The nucleoside analog Brd U was ip injected in beta-7-deficient mice(C57BL/6-Itgbtmlcgn/J)of male gender and age-matched male C57BL/J J mice(wild type)4,20,or 40 h before analysis.The total small intestine was isolated,dissected,and used for morphometrical studies.Brd U-positive epithelial cells were numbered in at least 15 hemi-crypts per duodenum,jejunum,and ileum of each animal.The outer most Brd U-positive cell(cellmax)was determined per hemi-crypt,numerically documented,and statistically analysed.RESULTS:Integrins containing the beta-7-chain were exclusively expressed on leukocytes.In the small intestinal mucosa of beta-7 integrin-deficient mice the number of intraepithelial lymphocytes was drastically decreased.Moreover,the Peyer’s patches of beta-7integrin-deficient mice appeared hypoplastic.In beta-7integrin-deficient mice the location of cellmax was found in a higher position than it was the case for the controls.The difference was already detected at 4 h after Brd U application,but significantly increased with time(40 h after Brd U injection)in all small intestinal segments investigated,i.e.,duodenum,jejunum,and ileum.Migration of small intestinal enterocytes was different between the experimental groups measured by cellmax locations.CONCLUSION:The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer. | Elke Kaemmerer Paula Kuhn Ursula Schneider Thomas Clahsen Min Kyung Jeon Christina Klaus Julia Andruszkow Michael Hrer Sabine Ernst Angela Schippers Norbert Wagner Nikolaus Gassler | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 3 | How to treat intestinal obstruction due to malignant recurrence after Whipple's resection for pancreatic head cancer: description of 2 new endoscopic techniques显示文摘The prognosis of pancreatic cancer remains poor,even after initial surgical therapy. Local recurrence after Whipple's pancreatico-duodenectomy may lead to intestinal obstruction at the level of the afferent limb or the alimentary limb. Endoscopic insertion of a selfexpandable metal stent(SEMS) into the intestinal malignant stricture is the preferred method of choice for palliation. We describe two new endoscopic techniques to treat a malignant intestinal obstruction with the insertion of a SEMS into the afferent limb and the alimentary limb. A case of malignant gastric outlet obstruction after a Whipple's resection was treated by the creation of an endoscopic gastrojejunostomy by the insertion of a lumen apposing Hot Axios stent in between the stomach and the alimentary limb under fluoroscopic and endoscopic ultrasound control. Biliary obstruction and jaundice caused by a malignant stricture of the afferent limb after a Roux-en-Y Whipple's resection was treated by the insertion of a SEMS by means of the single-balloon overtube-assisted technique under fluoroscopic control. Feasibility and advantages of both techniques are discussed. | Christina Mouradides Alaa Taha Ivan Borbath Pierre H Deprez Tom G Moreels | 2017 | World Journal of Gastroenterology2017，23，33： | 3 |
| 4 | Pelvic inflammatory disease and risk of invasive ovarian cancer and ovarian borderline tumors显示文摘 | Christina B. Rasmussen Mette T. Faber Allan Jensen Estrid H?gdall Claus H?gdall Jan Blaak?r Susanne K. Kjaer | 2013 | Cancer Causes & Control2013，，7： | 2 |
| 5 | Catalytic tar decomposition of biomass pyrolysis gas with a combination of dolomite and silica显示文摘 | CARIN M CHRISTINA H | 2002 | Biomass and Bioenergy2002，，23： | 1 |
| 6 | Morphotype pattern of Norwegian Sea deep sea benthic foraminifera and ecological implication 显示文摘 | CORLISS B H CHEN CHRISTINA | 1988 | Geology1988，16，： | 1 |
| 7 | Hypoxia -regula- ted gene expression in fetal wound regeneration and adult wound repair显示文摘 | Scheid A Wenger RH Christina H | 2000 | Pediatr Surg Int2000，16，4： | 1 |
| 8 | The anestheticconsiderations of trachebronchial foreign bodies in children :a literature review of 12979 cases显示文摘 | Christina W Fidkowski MD Zheng H | 2010 | Anesth Analg2010，111，4： | 1 |
| 9 | Magnetic pinning strength for the new SM-TM magnetic materials for use up to 550 ℃显示文摘 | CHEN Martin Walmer S | 2000 | J Appl Phys2000，87，9： | 1 |
| 10 | 显示文摘 | Lars-Ove H Ingela J Christina M | 1968 | Acta Chemica Scandinavica1968，22，： | 1 |
| 11 | Examining the structural relationships of destination image, tourist satisfaction and destination loyalty: An integrated approach 显示文摘 | Christina Qu H | 2008 | Tourism Management2008，29，4： | 1 |
| 12 | Gene expression analysis of toll - like receptor path- ways in heterophils from genetic chicken lines that dif- fer in their susceptibility to salmonella enteritidis 显示文摘 | MICHAEL H K HSIN I C CHRISTINA L S | 2012 | Front Genet2012，3，： | 1 |
| 13 | Diversity and spatio-temporal dynamics of dead wood in a temperate near-natural beech forest (Fagus sylvatica)显示文摘 | Goddert Oheimb Christina Westphal Werner H?rdtle | 2007 | European Journal of Forest Research2007，，3： | 1 |
| 14 | Targetoid hemosiderotic he-mangiomas (hobnail hemangiomas) are vascular lymphatic malforma-tions :A study of 12 pediatric cases 显示文摘 | Rola AD Christina L Afshin H | 2012 | J AM ACAD DERMATOL2012，66，1： | 1 |
| 15 | Effect of Indigofera aspalathoides against Dalton's ascitic lymphoma显示文摘 | Christina A J M Alwin Jose M Robert S J H | 2003 | Fitoterapia2003，74，3： | 1 |
| 16 | A Fuzzy Multi-Criteria Decision Support Procedure for Enhancing Information Delivery in Extended Enterprise Networks 显示文摘 | H C W Lau Christina W Y | 2003 | Engineering Application of Artificial Intelligence2003，16，1： | 1 |
| 17 | Templating mesoporous zeolites 显示文摘 | Kresten Egeblad Christina H Christensen Marina Kustova | 2008 | Chem Mater2008，20，3： | 1 |
| 18 | DNA-based MRI probes for specific detection of chronic exposure to amphetamine in lving brains显示文摘 | Christina H Liu Jia Q Ren Jinsheng Yang | 2009 | J Neurosci2009，29，10： | 1 |
| 19 | Pre-polish- ing the metal counterface of metal'UHMWPE wear pair with filler-filledUHMWPE composites to generate counterface changes for an effective re- duction in pure UHMWPE wear 显示文摘 | Yemei Liu Sujeet Kumar Sinha Christina Y H Lira | 2014 | Tribology letters2014，53，1： | 1 |
| 20 | Current management of tibial shaft fractures: A survey of 450 Canadian orthopedic trauma surgeons显示文摘 | Jason W Busse Emily Morton Christina Lacchetti Gordon H Guyatt Mohit Bhandari | 2008 | Acta Orthopaedica2008，，5： | 1 |
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