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| 1 | Cold dialysis and its impact on renal patients' health:An evidence-based mini review显示文摘Chronic renal disease is associated with advanced age,diabetes,hypertension,obesity,musculoskeletal problems and cardiovascular disease,the latter being the main cause of mortality in patients receiving haemodialysis(HD).Cooled dialysate(35 ℃-36 ℃) is recently employed to reduce the incidence of intradialytic hypotension in patients on chronic HD.The studies to date that have evaluated cooled dialysate are limited,however,data suggest that cooled dialysate improves hemodynamic tolerability of dialysis,minimizes hypotension and exerts a protective effect over major organs including the heart and brain.The current evidence-based review is dealing with the protective effect of cold dialysis and the benefits of it in aspects affecting patients' quality of care and life.There is evidence to suggest that cold dialysis can reduce cardiovascular mortality.However,large multicentre randomized clinical trials are urgently needed to provide further supporting evidence in order to incorporate cold dialysis in routine clinical practice. | Giorgos K Sakkas Argiro A Krase Christoforos D Giannaki Christina Karatzaferi | 2017 | World Journal of Nephrology2017，6，3： | 4 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | Implementation of a polling protocol for predicting celiac disease in videocapsule analysis显示文摘AIM: To investigate the presence of small intestinal villous atrophy in celiac disease patients from quantitative analysis of videocapsule image sequences.METHODS: Nine celiac patient data with biopsy-proven villous atrophy and seven control patient data lacking villous atrophy were used for analysis. Celiacs had biopsy-proven disease with scores of Marsh Ⅱ-Ⅲ C except in the case of one hemophiliac patient. At four small intestinal levels (duodenal bulb, distal duodenum, jejunum, and ileum), video clips of length 200 frames (100 s) were analyzed. Twenty-four measurements were used for image characterization. These measurements were determined by quantitatively processing the videocapsule images via techniques for texture analysis, motility estimation, volumetric reconstruction using shape-from-shading principles, and image transformation. Each automated measurement method, or automaton, was polled as to whether or not villous atrophy was present in the small intestine, indicating celiac disease. Each automaton's vote was determined based upon an optimized parameter threshold level, with the threshold levels being determined from prior data. A prediction of villous atrophy was made if it received the majority of votes (≥ 13), while no prediction was made for tie votes (12-12). Thus each set of images was classified as being from either a celiac disease patient or from a control patient. RESULTS: Separated by intestinal level, the overall sensitivity of automata polling for predicting villous atrophy and hence celiac disease was 83.9%, while the specificity was 92.9%, and the overall accuracy of automata-based polling was 88.1%. The method of image transformation yielded the highest sensitivity at 93.8%, while the method of texture analysis using subbands had the highest specificity at 76.0%. Similar results of prediction were observed at all four small intestinal locations, but there were more tie votes at location 4 (ileum). Incorrect prediction which reduced sensitivity occurred for two celiac patients with Marsh type Ⅱ pattern, which is characterized by crypt hyperplasia, but normal villous architecture. Pooled from all levels, there was a mean of 14.31 ± 3.28 automaton votes for celiac vs 9.67 ± 3.31 automaton votes for control when celiac patient data was analyzed (P<0.001). Pooled from all levels, there was a mean of 9.71 ± 2.8128 automaton votes for celiac vs 14.32 ± 2.7931 automaton votes for control when control patient data was analyzed (P<0.001). CONCLUSION: Automata-based polling may be useful to indicate presence of mucosal atrophy, indicative of celiac disease, across the entire small bowel, though this must be confirmed in a larger patient set. Since the method is quantitative and automated, it can potentially eliminate observer bias and enable the detectionof subtle abnormality in patients lacking a clear diagnosis. Our paradigm was found to be more efficacious at proximal small intestinal locations, which may suggest a greater presence and severity of villous atrophy at proximal as compared with distal locations. | Edward J Ciaccio Christina A Tennyson Govind Bhagat Suzanne K Lewis Peter H Green | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 3 |
| 4 | Demorgraphic charac-teristics,phenomenology,comorbidity and family history in200indi-viduals with body dysmorphic disorder显示文摘 | Phillips K A William M Christina Fav | 2005 | Psychosomatics2005，46，4： | 1 |
| 5 | Two magma series and associated ore deposit types in the Permian Emeishan large igneous province, SW China 显示文摘 | Zhou Mei-fu Arndt N T Malpas J Wang Christina Yan Kennedy A K | 2008 | Lithos2008，103，34： | 1 |
| 6 | Proteomics in clinical trials and practice present uses and future promise显示文摘 | NILOFER S A NABILA R CHRISTINA M A K | 2006 | Molecular & Cellular Proteomics2006，5，： | 1 |
| 7 | Proteomics in clinical trials and practice:present uses and future promise显示文摘 | Nilofer S A Nabila R Christina M A K | 2006 | Mol Cell Proteomies2006，5，： | 1 |
| 8 | Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyes cerevisiae显示文摘 | Derek L Christina K Kiersten A | 2011 | PLoS Genetics2011，7，3： | 1 |
| 9 | inhibition Interleukin -6 receptor directly blocks osteoclast formation in vitro anlt in vivo 显示文摘 | Roland A Christina B Gerhard K | 2009 | Arthirtis rheumatism2009，60，： | 1 |
| 10 | Identification of relevant ICF categories in patients with chronic health conditions : a Delphi exereise显示文摘 | Alarcos C Christina A Barbara K | 2004 | J Rehabil Med2004，36，44： | 1 |
| 11 | Use of atmospheric elemental size distributions in estimating aerosol sources in the Helsinki area显示文摘 | PAKKANEN T A KERMINEN V CHRISTINA H K | 2001 | Atmospheric Enviroment2001，35，： | 1 |
| 12 | Higher plant di- versity enhances soil stability in disturbed alpine ecosys- tems 显示文摘 | Mandy P Dominik A Christina K | 2009 | Plant and Soil2009，324，12： | 1 |
| 13 | Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy显示文摘 | Frank A Vicini Michael Sharpe Larry Kestin Alvaro Martinez Christina K Mitchell Michelle F Wallace Richard Matter John Wong | 2002 | International Journal of Radiation Oncology Biology Physics2002，，5： | 1 |
| 14 | Mediated resistance: tourism and the host community显示文摘 | Christina A J Anandam P K | 2001 | Annals of Tourism Research2001，28，4： | 1 |
| 15 | Effect of lo- calized muscle fatigue on vertical ground reaction forces and an- kle joint motion during running显示文摘 | CHRISTINA K A WHITE S C GILCHRIST L A | 2001 | Human Movem Sci2001，20，： | 1 |
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