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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data显示文摘 | Alan D Lopez Colin D Mathers Majid Ezzati Dean T Jamison Christopher JL Murray | 2006 | The Lancet . 2006 (9524)2006，，9524： | 2 |
| 4 | Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data显示文摘 | Alan D Lopez Colin D Mathers Majid Ezzati Dean T Jamison Christopher JL Murray | 2006 | 2006 (9524)2006，，9524： | 2 |
| 5 | Laparoscopic esophagomyotomy for achalasia in children:Areview显示文摘Esophageal achalasia in children is rare but ultimately requires endoscopic or surgical treatment. Historically, Heller esophagomyotomy has been recommended as the treatment of choice. The refinement of minimally invasive techniques has shifted the trend of treatment toward laparoscopic Heller myotomy(LHM) in adults and children with achalasia. A review of the available literature on LHM performed in patients < 18 years of age was conducted. The pediatric LHM experience is limited to one multiinstitutional and several single-institutional retrospective studies. Available data suggest that LHM is safe and effective. There is a paucity of evidence on the need for and superiority of concurrent antireflux procedures. In addition, a more complete portrayal of complications and long-term(> 5 years) outcomes is needed. Due to the infrequency of achalasia in children, these characteristics are unlikely to be defined without collaboration between multiple pediatric surgery centers. The introduction of peroral endoscopic myotomy and single-incision techniques, continue the trend of innovative approaches that may eventually become the standard of care. | T Kumar Pandian Nimesh D Naik Aodhnait S Fahy Arman Arghami David R Farley Michael B Ishitani Christopher R Moir | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 6 | Hyper-X Post-Flight Trajectory Reconstruction显示文摘 | Christopher D K Paul V T Robert C B | 2006 | Journal of Spacecraft and Rockets2006，43，1： | 1 |
| 7 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 8 | Methods for the Detection of Polyether Ionophore Residues in Poultry显示文摘 | Christopher T Elliott D Glenn Kennedy W John McCaughey | 1998 | Analyst1998，123，： | 1 |
| 9 | Minimal gradient encoding for robust estimation of diffusion anisotropy☆显示文摘 | Nikolaos G Papadakis Chris D Murrills Laurance D Hall Christopher L.-H Huang T Adrian Carpenter | 2000 | Magnetic Resonance Imaging2000，，： | 1 |
| 10 | Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data显示文摘 | Alan D Lopez Colin D Mathers Majid Ezzati Dean T Jamison Christopher JL Murray | 2006 | The Lancet2006，，9524： | 1 |
| 11 | Expertise differences in attentional strategies related to pilot decision makin显示文摘 | ANGELA T SCHRIVER DANIEL G MORROW CHRISTOPHER D WICHENS | 2008 | Human Factors2008，50，6： | 1 |
| 12 | Synthesis of Highly Ordered,Three-Dimensional,Macroporous Structures of Amorphous or Crystalline Inorganic Oxides,Phosphates,and Hybrid Composites显示文摘 | Brian T H Christopher F B Thang D | 2004 | Chem Mater2004，16，11： | 1 |
| 13 | Hyper-X post-flight trajectory reconstruction显示文摘 | CHRISTOPHER D K PAUL V T | 2006 | Journal of Spacecraft and Rockets2006，43，1： | 1 |
| 14 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 15 | Agglomeration effects in foreign direct investment and the pollution haven hypothesis 显示文摘 | Ulrich J W Christopher D T | 2009 | Environmental and Resource Economics2009，43，： | 1 |
| 16 | Multi-Level Modeling and Access Control for Data Sharing in Collaborative Design显示文摘 | Kim T Christopher D Cera C | 2006 | Advanced Engineering Informatics2006，20，1： | 1 |
| 17 | Transcripts ofMYB-like genes respond to phosphorous and nitrogen deprivation in Arabi-dopsis显示文摘 | CHRISTOPHER D T PEIYU ZENG ALICIA M R | 2004 | Planta2004，219，： | 1 |
| 18 | Metabolic aspects of programmed cell survival and cell death in the heart显示文摘 | ChristopHe D Heinrich T | 2000 | Cardiovascular Research2000，45，： | 1 |
| 19 | Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data显示文摘 | Alan D Lopez Colin D Mathers Majid Ezzati Dean T Jamison Christopher JL Murray | 2006 | The Lancet2006，，9524： | 1 |
| 20 | A knowledge-based approach to the statistical mapping of climate显示文摘 | Christopher D Wayne P G George H T | 2002 | Cli- mate Research2002，22，： | 1 |
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