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| 1 | Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation:Effects on virus replication and recurrent hepatitis显示文摘瞄准:决定 calcineurin 禁止者, cyclosporine 和 tacrolimus 的效果,在丙肝上,在病人的周期性的丙肝的病毒(HCV ) 复制和活动张贴肝移植。方法:在我们的中心为在 1999 和 2003 之间的联系 HCV 的肝肝硬化收到了肝移植的 107 个病人的一个队的数据回顾地被分析。浆液 HCV-RNA 的水平和周期性的肝炎的活动在作为主要抑制免疫力的代理人和没在移植以后在开始的 12 瞬间以内导致胆汁的复杂并发症的不那样类似的抑制免疫力的政体收到了 cyclosporine 或 tacrolimus 的 47 个病人之间被比较。结果:HCV-RNA 在移植以后在 3 瞬间以内增加了,但是 cyclosporine 组和 tacrolimus 组之间的差别是不足道的(在 12 瞬间的 P=0.49 ) 。另外,由浆液 transaminases 决定了的周期性的肝炎并且门发炎和纤维变性的组织学的分级没在 12 瞬间(P=0.34 ) 以后显示出有效差量。结论:一个主要抑制免疫力的代理人不在肝移植以后在感染 HCV 的病人影响周期性的肝炎的正式就职或严厉的 Cyclosporine 或 tacrolimus。 | Philip Hilgard Alisan Kahraman Nils Lehmann Cornelia Seltmann Susanne Beckebaum R Stefan Ross Hideo A Baba Massimo Malago Christoph E Broelsch Guido Gerken | 2006 | World Journal of Gastroenterology2006，12，5： | 235 |
| 2 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | Bilateral vs unilateral placement of metal stents for inoperable highgrade hilar biliary strictures: A systemic review and meta-analysis显示文摘BACKGROUND Bilateral vs unilateral biliary stenting is used for palliation in malignant biliary obstruction.No clear data is available to compare the efficacy and safety of bilateral biliary stenting over unilateral stenting.AIM To assess the efficacy and safety of bilateral vs unilateral biliary drainage in inoperable malignant hilar obstruction.METHODS PubMed,Embase,Scopus,and Cochrane databases,as well as secondary sources(bibliographic review of selected articles and major GI proceedings),were searched through January 2019.The primary outcome was the re-intervention rate.Secondary outcomes were a technical success,early and late complications,and stent malfunction rate.Pooled odds ratio(OR)and 95%confidence interval(CI)were calculated for each outcome.RESULTS A total of 9 studies were included(2 prospective Randomized Controlled Study,5 retrospective studies,and 2 abstracts),involving 782 patients with malignant hilar obstruction.Bilateral stenting had significantly lower re-intervention rate compared with unilateral drainage(OR=0.59,95%CI:0.40-0.87,P=0.009).There was no difference in the technical success rate(OR=0.7,CI:0.42-1.17,P=0.17),early complication rate(OR=1.56,CI:0.31-7.75,P=0.59),late complication rate(OR=0.91,CI:0.58-1.41,P=0.56)and stent malfunction(OR=0.69,CI:0.42-1.12,P=0.14)between bilateral and unilateral stenting for malignant hilar biliary strictures.CONCLUSION Bilateral biliary drainage had a lower re-intervention rate as compared to unilateral drainage for high grade inoperable malignant biliary strictures,with no significant difference in technical success,and early or late complication rates. | Munish Ashat Sumant Arora Jagpal S Klair Christopher A Childs Arvind R Murali Frederick C Johlin | 2019 | World Journal of Gastroenterology2019，25，34： | 5 |
| 5 | Eleetrodeposition of aluminium and aluminium/ platinum alloys from A1C13/benzyhrimethylammonium chloride room temperature ionic liquids 显示文摘 | Abbott Andrew P Eardley Christopher A Farley Nicola R S | 2001 | Journal of Applied Electrochemistry2001，31，： | 1 |
| 6 | Effect of crystal nature on upconversion luminescence in Er3:ZrO2nanocrystals显示文摘 | PATRAC A CHRISTOPHER S FRIEND R K | 2003 | Appl Phys Lett2003，，83： | 1 |
| 7 | Visible light photoredox catalysis with transition metal complexes:applications in organic synthesis显示文摘 | Christopher K P Danica A R David W C M | 2013 | Chem Rev2013，113，： | 1 |
| 8 | Analysis of the anticoccidial drug,halofuginone,in chicken feed using gas-liquid chromatography and high-performance liquid chromatography显示文摘 | Anderson A Christopher D H Woodhouse R N | 1979 | Journal of Chromatography1979，168，： | 1 |
| 9 | Flywheel Technology Development Program for Aerospace Applications显示文摘 | Christopher D A Beach R | 1998 | IEEE AES Systems Magazine1998，13，6： | 1 |
| 10 | Identification and mapping of polymorphic SSR markers from expressed gene sequences of barley and wheat显示文摘 | HOLTON T A CHRISTOPHER J T MCCLURE L HARKER N HENRY R J | 2002 | Molecular Breeding2002，9，： | 1 |
| 11 | Characterisation by EIS of ternary Mg alloys synthesized by mechanical alloying显示文摘 | CHRISTOPHER M A BRETT DIAS L TR1NDADE B FISCHER R M1ES S | 2006 | Electrochimica Acta2006，51，： | 1 |
| 12 | Effectiveness of geosynthetics for roadway construction in cold regions : results of a multi-use test section 显示文摘 | Hayden S A Humprey D N Christopher B R | 1999 | Proceedings of Geosynthetics1999，2，： | 1 |
| 13 | Coupling loss theory of single-mode waveguide resonators显示文摘 | Christopher A Hill Denis R Hall | 1985 | Appl Opt1985，24，9： | 1 |
| 14 | Ciliary beat pattern is associated with specific ultrastructural defects in primary ciliary dyskinesia显示文摘 | M A Chilvers R Andrew O Christopher | 2003 | Journal of Allergy & Clinical Immunology2003，112，3： | 1 |
| 15 | Cardiac troponin T in chest pain unit patients without ischemic electrocardiographic changes: angiographic correlates and long-term clinical outcomes显示文摘 | Christopher R deFilippi Monica Tocchi Rohit J Parmar Salvatore Rosanio Gerard Abreo Marjorie A Potter Marschall S Runge Barry F Uretsky | 2000 | Journal of the American College of Cardiology2000，，7： | 1 |
| 16 | Pfinder: real-time tracking of the human body显示文摘 | Christopher R W Ali A Trevor D | 1997 | IEEE Transactions on PAMI1997，19，7： | 1 |
| 17 | Pfinder:real-time tracking of the human body显示文摘 | CHRISTOPHER R W AZARBAYEJANI A DARRELL T | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，7： | 1 |
| 18 | Flywheel technology development program for aerospace applications 显示文摘 | Christopher D A Beach R | 1998 | IEEE xplore Digital Library1998，13，6： | 1 |
| 19 | The protestant work ethic and attributions of responsibility : Applications of the trian- gle model 显示文摘 | Christopher A N Schlenker B R | 2005 | Journal of Applied Social Psychology2005，，7： | 1 |
| 20 | Soluble nanoparticles as removable pore templates for the preparation of polymer ultrafiltration membranes显示文摘 | Christoph R Kellenberger Norman A Luechinger Alexandros Lamprou | 2012 | Journal of Membrane Science2012，38，： | 1 |
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