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| 1 | Liver transplantation in patients with incidental hepatocellular carcinoma/cholangiocarcinoma and intrahepatic cholangiocarcinoma: a single-center experience显示文摘BACKGROUND: Reports of liver transplantation(LT) in patients with mixed hepatocellular carcinoma/cholangiocarcinoma(HCC/CC) and intrahepatic cholangiocarcinoma(ICC) are modest and have been mostly retrospective after pathological categorization in the setting of presumed HCC. Some studies suggest that patients undergoing LT with small and unifocal ICC or mixed HCC/CC can achieve about 40%-60% 5-year post-transplant survival. The study aimed to report our experience in patients undergoing LT with explant pathology revealing HCC/CC and ICC.METHODS: From a prospectively maintained database, we performed cohort analysis. We identified 13 patients who underwent LT with explant pathology revealing HCC/CC or ICC. RESULTS: The observed recurrence rate post-LT was 31%(4/13) and overall survival was 85%, 51%, and 51% at 1, 3 and 5 years, respectively. Disease-free survival was 68%, 51%, and 41% at 1, 3 and 5 years, respectively. In our cohort, four patients would have qualified for exception points based on updated HCC Organ Procurement and Transplantation Network imaging guidelines. CONCLUSIONS: Lesions which lack complete imaging characteristics of HCC may warrant pre-LT biopsy to fully elucidate their pathology. Identified patients with early HCC/CC or ICC may benefit from LT if unresectable. Additionally, incorporating adjunctive perioperative therapies such as in the case of patients undergoing LT with hilar cholangiocarcinoma may improve outcomes but this warrants further investigation. | Mohammed Elshamy Naftali Presser Abdulrahman Y Hammad Daniel J Firl Christopher Coppa John Fung Federico N Aucejo | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 6 |
| 2 | Analysis of a Successful Immune Response against Hepatitis C Virus显示文摘 | Stewart Cooper Ann L Erickson Erin J Adams Joe Kansopon Amy J Weiner David Y Chien Michael Houghton Peter Parham Christopher M Walker | 1999 | Immunity1999，，4： | 3 |
| 3 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Christopher J L Murray Theo Vos Rafael Lozano Mohsen Naghavi Abraham D Flaxman Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 4 | A tabu search heuristic for the vehicle routing problem with backhauls and time windows显示文摘 | Christophe D Potvin J Y Rousseau J M | 1997 | Transportation Science1997，31，1： | 1 |
| 5 | Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates显示文摘 | Yuriy R L Christopher J B Zhen Y L | 2007 | Nature2007，447，： | 1 |
| 6 | Transformation of trichothecene mycotoxins by microorganisms from fish gigesta显示文摘 | GUAN Shu HE Jianwei CHRISTOPHER J Y | 2009 | Aquaculture2009，290，： | 1 |
| 7 | Chemicalmodification of stem bromelain with anhydride groupsto enhance its stability and catalytic activity 显示文摘 | XUE Y WU C Y CHRISTOPHER J | 2010 | Journal ofMolecular Catalysis B: Enzymatic2010，63，34： | 1 |
| 8 | Angioplasty and Stenting in Carotid Dissection with or without Associated Pseudoaneurysm显示文摘 | Kadkhodayan Y Jeck DT Christopher J | 2005 | AJNR Am J Neuroradiol2005，26，9： | 1 |
| 9 | Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates 显示文摘 | Yuriy R L Christopher J B Zhen Y L | 2007 | Nature2007，447，： | 1 |
| 10 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 11 | Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates 显示文摘 | YURIY R L CHRISTOPHER J B ZHEN Y | 2007 | Nature2007，447，7147： | 1 |
| 12 | Isolation of tellurite- and selenite-resistant bacteria from hydrothermal vents of the Juan de Fuca Ridge in the Pacific Ocean 显示文摘 | Christopher R Natalia Y Erko S J | 2002 | Applied and Environmental Microbiology2002，68，： | 1 |
| 13 | The restricted isometry property for random block diagonal matrices 显示文摘 | Armin E Han L Y Christopher J R | 2015 | Applied and Computational Harmonic Analysis2015，38，1： | 1 |
| 14 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 15 | A Study of the Performante of Microfabricated Electroosmotic Pump显示文摘 | Hu J S and Chao Christopher Y H | | Sensors and Actuators A0，2007，： | 1 |
| 16 | Fatigue en- hancement of concrete beam with ECC layer 显示文摘 | Christopher K Y L CheungY N Zhang J | 2007 | Cement and Concrete Research2007，29，6： | 1 |
| 17 | Increased dietary intake of co-3 polyunsaturated fatty acidsreduces pathological retinal angiogenesis显示文摘 | Kip M C San Giovanni J P Lofqvist C Christopher M A Chen J HiguchiA Hong S Elke A P Majchrzak S Carper D Ann H Kang J X Emily Y C Norman S Charles N S | 2007 | Nature Medicine2007，13，： | 1 |
| 18 | Fully Automated Synthesis System of 3-Deoxy-3- Fluorothymidine显示文摘 | Seung J O Christoph M Dae Y C | 2004 | Nucl Med Biol2004，，31： | 1 |
| 19 | Elucidating the role of silica surfaces in the ring - opening polymerization of laetide: catalytic behavior of silica - immobilized zinc β - diiminate complexes 显示文摘 | KUNQUAN Y CHRISTOPHER J W | 2004 | Journal of Catalysis2004，222，2： | 1 |
| 20 | Numerical study of electroosmotic (EO) flow in mierofabricated EO pump with overlapped electrical double layer (EDL) 显示文摘 | J S Hu Christopher Y H Chao | 2007 | International Journal of Refrigeration2007，30，2： | 1 |
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