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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Persistent hepatitis C virus (HCV) infection impairs HCV‐specific cytotoxic T cell reactivity through Mcl‐1/Bim imbalance due to CD127 down‐regulation显示文摘 | J. R. Larrubia M. U. Lokhande S. García‐Garzón J. Miquel A. González‐Praetorius T. Parra‐Cid E. Sanz‐de‐Villalobos | 2012 | Journal of Viral Hepatitis2012，，2： | 3 |
| 3 | Soil inhabiting nema- todes of the genera Trischistoma, Tripylina and Tripyla from Mexico and the USA with descriptions of new species 显示文摘 | Cid del Prado-Vera I Ferris H Nadler S A | 2010 | Journal of Nema- tode Morphology and Systematics2010，13，： | 1 |
| 4 | In situ synthesis of magnetic multiwalled carbon nanotube composites for the clean - up of ( fluoro ) quinolones from human plasma prior to ultrahigh pressure liquid chromatography analysis 显示文摘 | Morales -Cid G Fekete A Simonet B M | 2010 | Anal Chem2010，82，： | 1 |
| 5 | Four new species of Tripylina Brzeski, 1963 (Enoplida:Tripylidae) from M~xico, with an emended diagnosis of the genus 显示文摘 | Cid del Prado-Vera I Ferris H Nadler S A | 2012 | Journal of Nematode Morphology and Systematics2012，15，： | 1 |
| 6 | Production,partial purification and characterization of α-L-rhamnosidase from Penicillium ulaiense显示文摘 | RAJAL V B CID A G ELLENRIEDER G | 2009 | World J Microbiol Biot2009，25，6： | 1 |
| 7 | Third-order nonlinear optical properties of bismuth-borate glasses measured by conventional and thermally managed eclipse Z scan 显示文摘 | Gomes A S L Falc o Filho E L de Araujo Cid B etal | 2007 | J Appl Phys2007，101，03： | 1 |
| 8 | Analysis and enhancement of astaxanthin accumulation in Haematococcus pluvialis显示文摘 | Orosa M Franqueira D Cid A | 2005 | Bioresouree Technology2005，96，： | 1 |
| 9 | Treatment of polymyalgia rheumatica: a systematic review 显示文摘 | Hernmdez-Rodriguez J Cid M C L6pez-Soto A | 2009 | Archives Internal Medicine2009，169，20： | 1 |
| 10 | Sources of intense geomagnetic storms over the rise of solar cycle 23显示文摘 | Cid C Hidalgo M A Saiz E Y Cerrato | 2004 | Solar Phys2004，，： | 1 |
| 11 | Intestinal myiasis caused by Eristalis tenax显示文摘 | Aguilera A Cid A Regueiro BJ | 1999 | J Clin Microbiol1999，37，： | 1 |
| 12 | Persistent hepatitis C virus (HCV) infection impairs HCV‐specific cytotoxic T cell reactivity through Mcl‐1/Bim imbalance due to CD127 down‐regulation显示文摘 | J. R. Larrubia M. U. Lokhande S. García‐Garzón J. Miquel A. González‐Praetorius T. Parra‐Cid E. Sanz‐de‐Villalobos | 2012 | Journal of Viral Hepatitis2012，，2： | 1 |
| 13 | Effects of nitrogen source and growth phase on proximate biochemical composition,lipid classes and fatty acid profile of the marine microalga Isochrysis galbana显示文摘 | FIDALGO J P CID A TORRES E | 1998 | Aquaculture1998，166，12： | 1 |
| 14 | On the Sign of the Green' s Function Associated to Hill' s Equation with an Indefinite Potential 显示文摘 | Cabada A Cid J A | 2008 | Appl Math Comput2008，205，1： | 1 |
| 15 | Effects of nitrogen source andgrowth phase on proximate biochemical composition,lipid classesand fatty acid profile of the marine microalga Isochrysis galbana显示文摘 | Fidalgo J P Cid A Torres E | 1998 | Aquaculture1998，166，12： | 1 |
| 16 | Passivitybased integral control of a Boost converter for large-signal stability显示文摘 | LEYVA R CID PASTOR A ALONSO C | 2006 | Control Theory and Applications IEE Proceedings2006，153，13： | 1 |
| 17 | Endothelial cells, antineutrophil cytoplasmic antibodies, and cytokines in the pathogenesis of systemic vasculitis显示文摘 | Cid MC Segarra M Garcia-Martlnez A | 2004 | Curr Rheu- matol Rep2004，6，3： | 1 |
| 18 | Positivity and lower and upper solutions for fourth order boundary value problems 显示文摘 | Cabada A Cid J Sanchez L | 2007 | Nonlinear Anal2007，67，： | 1 |
| 19 | Carotenoid accumulation in Haematococcus pluvialis in mixotrophic growth显示文摘 | Orosa M Franqueira D Cid A | 2001 | Biotechnology Letters2001，23，5： | 1 |
| 20 | Silver nanoparticles formation within unsaturated polyester/styrene resins induced by UV irradiation and thermal treatment显示文摘 | Antonio M Brito-Silva Cid B de Araujo Fabio A Brayner | 2010 | Polymer Engi-neering and Science2010，50，12： | 1 |
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