|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Genetic and phenological variation of tocochromanol(vitamin E)content in wild(Daucus carota L.var.carota)and domesticated carrot(D.carota L.var.sativa)显示文摘Carrot roots(Daucus carota L.var.sativa)produce tocochromanol compounds,collectively known as vitamin E.However,little is known about their types and amounts.Here we determined the range and variation in types and amounts of tocochromanols in a variety of cultivated carrot accessions throughout carrot postharvest storage and reproductive stages and in wild-type roots(Daucus carota L.var.carota).Of eight possible tocochromanol compounds,we detected and quantified α-,and the combined peak for β-and γ-forms of tocopherols and tocotrienols.Significant variation in amounts of tocochromanol compounds was observed across accessions and over time.Large increases in a-tocopherol were noted during both reproductive growth and the postharvest stages.The variation of tocochromanols in carrot root tissue provides useful information for future research seeking to understand the role of these compounds in carrot root tissue or to breed varieties with increased levels of these compounds. | Claire H Luby Hiroshi A Maeda Irwin L Goldman | 2014 | Horticulture Research2014，1，1： | 6 |
| 3 | 纳米技术:基于相关指标及统计数据的述评(Ⅱ)显示文摘3 纳米技术应用领域及机构分析3.1概述研究及分析人员认为,纳米技术可能发展为下一代通用技术,这意味着纳米技术将很可能迅速发展成为在各应用领域及产业广泛应用的技术㈣。其主要依据是纳米技术使得在基本原子和分子水平更深入地认识和控制物质成为可能,从而有助于改进几乎所有产业的制造工艺。 | Christopher Palmberg Hélène Dernis Claire Miguet 张树良 | 2011 | 科技导报2011，29，23： | 5 |
| 4 | The Surgical Treatment and Outcome of Nonmetastatic Extremity Osteosarcoma with Pathological Fractures显示文摘 | Zhi-Ping Deng Yi Ding Ajay Puri Edward H M Wang Ashish Gulia Claire Durban Xiao-Hui Niu | 2015 | Chinese Medical Journal2015，，19： | 2 |
| 5 | Tumorigenesissuppressor Pdcd4 dow n-regulates mitogen-activated pro-tein kinase 1 expression to suppress colon carcinoma cellinvasion显示文摘 | Yang H S Matthews C P Clair T | 2006 | Mol Cell Biol2006，26，4： | 1 |
| 6 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 7 | Association within a family of a valanced autosomal translocation with major mental illness 显示文摘 | St Clair D Blackwood D Evans H J | 1990 | Lancet1990，336，8706： | 1 |
| 8 | Infection with Influenza Virus Induces IL-33 in Murine Lungs显示文摘 | Le Goffic Ronan Arshad Muhammad Imran Rauch Michel L’Helgoualc’h Annie Delmas Bernard Piquet-Pellorce Claire Samson Michel | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，6： | 1 |
| 9 | Simultaneous optimization of capsule and tablet formulation using response surface methodology 显示文摘 | Iskandarani B Clair J H Patel P | 1993 | Drug Dev Ind Pharm1993，19，16： | 1 |
| 10 | Mechanical behavior of cellulose microfibrils in tension wood in relation with maturation stress generation 显示文摘 | CLAIR B ALMERAS T YAMAMOTC H | 2006 | Biophysical Journal2006，91，3： | 1 |
| 11 | Association within a family of a balanced autosomal translocation with major mental illness显示文摘 | St Clair D Blackwood D Muir W Carothers A Walker M Spowart G Gosden C Evans H J | | 0，，8706： | 1 |
| 12 | Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1cells显示文摘 | Meryl H Claire E Y Jean-Fran ois L | 2007 | Biochem Biophys Res Commun2007，361，1： | 1 |
| 13 | Gene expression profiling of 3T3-L1 adipocytes exposed to phloretin显示文摘 | Meryl H Claire E Y Christiane M D | 2010 | J Nutr Biochem2010，21，7： | 1 |
| 14 | Gene stacking in transgenic plants- the challenge for 21st century plant biotechnology 显示文摘 | CLAIRE H | 2005 | Plant Biotechnology Journal2005，3，： | 1 |
| 15 | Practical concepts in capability and performance of transmission lines显示文摘 | St Clair H P | 1953 | AIEE Transactions1953，72，： | 1 |
| 16 | Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with hu- man immunodeficiency virus reverse transcriptase显示文摘 | FURMAN P A FYFE J A ST CLAIR M H | 1986 | Proc Natl Acad Sci USA1986，83，21： | 1 |
| 17 | The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function显示文摘 | HON REN H CLAIRE E R SABINE M | 2005 | PNAS2005，102，1： | 1 |
| 18 | High rates of anaerobic methanotrophy at low sulfate concentrations with implications for past and present methane levels 显示文摘 | Beal E J Claire M W and House C H | 2011 | Geology2011，9，： | 1 |
| 19 | Phylogenetic structure of Xanthomonas determined by comparison of gyrB sequences 显示文摘 | Neil P Claire C John H | 2009 | International Journal of Systematic and Evolutionary Microbiology2009，59，： | 1 |
| 20 | Simultaneous optimization of capsule and tablet formulation using response surface methodology显示文摘 | Iskandarani B Clair J H Patel P | 1993 | Drug Der Ind Pharm1993，19，16： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员