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| 1 | 显示文摘 | Thompson D W St Clair A K | 1997 | Chem Mater1997，9，2： | 1 |
| 2 | The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function显示文摘 | HON REN H CLAIRE E R SABINE M | 2005 | PNAS2005，102，1： | 1 |
| 3 | Aggregating behavior of ovigerous female red king crabs,Paralithodes camtschaticus,in Auke Bay, Alaska显示文摘 | C E O'Clair and T C Shirley | 1993 | Can J Fish Aquat Sci1993，50，： | 1 |
| 4 | 显示文摘 | St Clair A K Thompson D W | 1998 | Polym Mater Sci Eng1998，78，： | 1 |
| 5 | PKA-independent activation of I (f) by cAMP in mouse sinoatrial myocytes显示文摘 | ST CLAIR J R LIAO Z LARSON E D | 2013 | Channels(Austin)2013，7，4： | 1 |
| 6 | Asymptomatic arrhythmias in patients with symptomatic paroxysmal atrial fibrillation and paroxysmal supraventricular tachycardia 显示文摘 | PAGE R L WILKINSON W E CLAIR W K | 1994 | Circulation1994，89，： | 1 |
| 7 | Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies显示文摘 | Celeste Leigh Pearce Claire Templeman Mary Anne Rossing Alice Lee Aimee M Near Penelope M Webb Christina M Nagle Jennifer A Doherty Kara L Cushing-Haugen Kristine G Wicklund Jenny Chang-Claude Rebecca Hein Galina Lurie Lynne R Wilkens Michael E Carney Mar | 2012 | Lancet Oncology2012，，： | 1 |
| 8 | Agency problems and the simultaneity of financial decision making The role of institutional ownership显示文摘 | CLAIRE E CRUTCHLEY MARLIN R H JENSEN | 1999 | International Review of Financial Analysis1999，82，： | 1 |
| 9 | Genetic variation of piper- idine alkaloids in Pinus ponderosa: a common garden study 显示文摘 | Gerson E A Kelsey R G St Clair J B | 2009 | Annals of Botany2009，3，103： | 1 |
| 10 | Long Term Toxicityof a Roundup Herbicide and a Roundup-Tolerant Genetically Mod-ified Maize显示文摘 | SéRALINI G E CLAIR E MESNAGE R | 2012 | Food and Chemical Toxicology2012，50，11： | 1 |
| 11 | Long term toxicity of a Roundup herbicide and a Roundup-tolerant ge- netically modified maize显示文摘 | SIRALINI G E CLAIR E MESNAGE R | 2012 | Food Chem Toxicol2012，50，11： | 1 |
| 12 | Control of surface reflectivity/conductivity in silvered polyimide films via in situ thermal reduction of silver Ⅰ: Complexes 显示文摘 | Southward R E Thompson D W St Clair A K | 1996 | Polym Mater Sci Eng1996，74，： | 1 |
| 13 | Interferon re- duces cell surface expression of Annexin 2 and suppresses the invasive capacity of prostate cancer cells 显示文摘 | Claire Hastie John R Masters Stephen E Moss | 2008 | Biological Chemistry2008，283，18： | 1 |
| 14 | Long term toxicity of a roundup herbicide and a roundup-tolerant genetically modified maize显示文摘 | Séralini GE Clair E Mesnage R | | 0，，11： | 1 |
| 15 | Psychological con- tract in the 21 st century: what employees value most and how well organizations are responding to these expecta- tions显示文摘 | Lester R S Claire W E Kickul J | 2001 | H umman Resource Planning2001，24，1： | 1 |
| 16 | Alcohol Use and Binge Drinking Among Women of Childbearing Age - United States, 2006-2010显示文摘 | Marchetta Claire M Denny Clark H Floyd R Louise Cheal Nancy E Sniezek Joseph E McKnight-Eily Lela R | 2012 | EN2012，，28： | 1 |
| 17 | Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize显示文摘 | Seralini G E Mesnage R Clair E | 2012 | Food Chem Toxicol2012，50，11： | 1 |
| 18 | Infliximab (chimeric anti-tumor necrosis factor a monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomized phase III trial 显示文摘 | Maini R Clair E W Breedveld F | 1999 | The Lancet1999，354，9194： | 1 |
| 19 | Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma显示文摘BACKGROUND In the contemporary era of cancer immunotherapy,an abundance of clinical and translational studies have reported radiotherapy(RT)and immunotherapies as a viable option for immunomodulation of many cancer subtypes,with many related clinical trials ongoing.In locally advanced disease,chemotherapy or chemoradiotherapy followed by surgical excision of the tumour remain the principal treatment strategy in oesophageal adenocarcinoma(OAC),however,the use of the host immune system to improve anti-tumour immunity is rapidly garnering increased support in the curative setting.AIM To immunophenotype OAC patients’immune checkpoint(IC)expression with and without radiation and evaluate the effects of checkpoint blockade on cell viability.METHODS In the contemporary era of cancer immunotherapy,an abundance of studies have demonstrated that combination RT and IC inhibitors(ICIs)are effective in the immunomodulation of many cancer subtypes,with many related clinical trials ongoing.Although surgical excision and elimination of tumour cells by chemotherapy or chemoradiotherapy remains the gold standard approach in OAC,the propagation of anti-tumour immune responses is rapidly garnering increased support in the curative setting.The aim of this body of work was to immunophenotype OAC patients’IC expression with and without radiation and to establish the impact of checkpoint blockade on cell viability.This study was a hybrid combination of in vitro and ex vivo models.Quantification of serum immune proteins was performed by enzyme-linked immunosorbent assay.Flow cytometry staining was performed to evaluate IC expression for in vitro OAC cell lines and ex vivo OAC biopsies.Cell viability in the presence of radiation with and without IC blockade was assessed by a cell counting kit-8 assay.RESULTS We identified that conventional dosing and hypofractionated approaches resulted in increased IC expression(PD-1,PD-L1,TIM3,TIGIT)in vitro and ex vivo in OAC.There were two distinct subcohorts with one demonstrating significant upregulation of ICs and the contrary in the other cohort.Increasing IC expression post RT was associated with a more aggressive tumour phenotype and adverse features of tumour biology.The use of anti-PD-1 and anti-PD-L1 immunotherapies in combination with radiation resulted in a significant and synergistic reduction in viability of both radiosensitive and radioresistant OAC cells in vitro.Interleukin-21(IL-21)and IL-31 significantly increased,with a concomitant reduction in IL-23 as a consequence of 4 Gray radiation.Similarly,radiation induced an anti-angiogenic tumour milieu with reduced expression of vascular endothelial growth factor-A,basic fibroblast growth factor,Flt-1 and placental growth factor.CONCLUSION The findings of the current study demonstrate synergistic potential for the use of ICIs and ionising radiation to potentiate established anti-tumour responses in the neoadjuvant setting and is of particular interest in those with advanced disease,adverse features of tumour biology and poor treatment responses to conventional therapies. | Noel E Donlon Maria Davern Fiona O'Connell Andrew Sheppard Aisling Heeran Anshul Bhardwaj Christine Butler Ravi Narayanasamy Claire Donohoe James J Phelan Niamh Lynam-Lennon Margaret R Dunne Stephen Maher Jacintha O'Sullivan John V Reynolds Joanne Lysaght | 2022 | World Journal of Gastroenterology2022，28，21： | 1 |
| 20 | Geneticallymodified crops safety assessments: present limits and possible improvements 显示文摘 | SERALINI G E MESNAGE R CLAIR E | 2011 | Environ Sci Europe2011，23，1： | 1 |
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