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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Establishment of a Cre/loxP recombination system for N-terminal epitope tag- ging of genes in Tetrahymena显示文摘 | Clara J L Busch M Alexander V | 2010 | Microbiol2010，10，46： | 1 |
| 3 | Uncommon patterns of presentation ofleukemia显示文摘 | Carlos V Maria RB Clara DB | 1999 | Hematol Oneol1999，17，1： | 1 |
| 4 | Appraisal of the Horse Creek air injection project performance 显示文摘 | Clara C Zelenko V Schirmer P | 1998 | SPE 49519-MS1998，，： | 1 |
| 5 | Synthetic grafts for anterior cruciate ligament rupture: 19-year outcome study 显示文摘 | Alberto V Clara T Claudio L | 2010 | The Knee2010，2，： | 1 |
| 6 | Relation Between The 6-Minute Walk Test And The Maximum Oxygen Consumption 显示文摘 | Walter V Clara L Luis F | 2007 | Chest Meeting Abstracts2007，，132： | 1 |
| 7 | Environmental assessment of chemical products from a Norwegian biorefinery显示文摘 | INGUNN S M ANDREAS B CLARA V | 2015 | Journal of Cleaner Production2015，94，： | 1 |
| 8 | Synthetic grafts for anterior cruc-iate ligament rupture:19-year outcome study显示文摘 | Alberto V Clara T Claudio L | 2010 | Knee2010，17，2： | 1 |
| 9 | Real-time price discovery in global stock, bond and foreign exchange markets显示文摘 | Torben G A Bollerslev T Clara V | 2007 | International Economics2007，，73： | 1 |
| 10 | MHC class II sequences of susceptibility and protection in Mexicans with autoimmune hepatitis显示文摘 | Miriam Nohemí Vázquez-García Carmen Aláez Angélica Olivo Héctor Debaz Elva Pérez-Luque Ana Burguete Silvia Cano Gabriela de la Rosa Norma Bautista Arturo Hernández José Bandera Luis Fernando Torres David Kershenobich Fernando Alvarez Clara Gorodezky | 1998 | Journal of Hepatology1998，，6： | 1 |
| 11 | Variability in responses of partially ripe bananas to 1-methylcyclopropene显示文摘 | Clara P Eduardo V B Vilas B | 2003 | Postharvest Biol Technol2003，28，： | 1 |
| 12 | Molecular analysis of the PROP1 and HESX1 genes in patients with septo-optic dysplasia and/or pituitary hormone deficiency显示文摘 | Cruz J B Nunes V S Clara S A Perone D Kopp P Nogueira C R | | 0，，： | 1 |
| 13 | Floral volatiles play a key role in specialized ant pollination显示文摘 | Clara de V Carlos M H Stefan D | 2014 | Perspectives in Plant Ecology Evolution and Systematics2014，16，1： | 1 |
| 14 | Acute Right Atrial and Ventricular Infarction显示文摘 | Jesús Vargas-Barrón ángel Romero-Cárdenas Francisco J. Roldán Clara A. Vázquez-Antona | 2007 | 2007，，1： | 1 |
| 15 | Uncommon patterns of presentation ofleukemia显示文摘 | Carlos V Maria RB Clara DB | 1999 | Hematol Oncol1999，17，1： | 1 |
| 16 | An uhra-low-power preci- sion rectifier for biomedical sensors interfacing显示文摘 | Esther R V Philip C Clara L M | 2009 | Sensors and Actu- ators A : Physical2009，153，2： | 1 |
| 17 | β-淀粉样蛋白损害星形胶质细胞在阿尔茨海默病中对营养不良突触的吞噬作用显示文摘摘要在阿尔茨海默病(AD)中,在β-淀粉样蛋白斑块周围发现了反应性星形胶质细胞和营养不良的神经突(异常的突触前元件)。笔者的前期研究已经表明,反应性星形胶质细胞会包裹、吞噬和降解APP小鼠以及AD患者海马中营养不良的突触,但仅波及不到7%的营养不良神经突,这表明星形胶质细胞在AD中的吞噬能力降低。本研究旨在通过分析原代星形胶质细胞培养物对分离突触(突触神经小体,SNs)吞噬和降解的能力来深入了解其潜在机制。SNs分别来自APP(包含营养不良性突触和β淀粉样肽)小鼠、Tau(包含AT8-和AT100-阳性磷酸化Tau)小鼠以及WT(对照)小鼠。我们发现与SNs-WT相比,星形胶质细胞的吞噬和降解能力在SNs-APP大大降低,但在AT8/AT100阳性的SNs-Tau却没有。在12月大的APP小鼠的海马中证实了星形胶质细胞吞噬能力的降低,因为只有(1.60±3.81)%的斑块状星形胶质细胞具有吞噬结构。 | Maria V Sanchez-Mico Sebastian Jimenez Angela Gomez-Arboledas Clara Muñoz-Castro Carmen Romero-Molina Victoria Navarro Elisabeth Sanchez-Mejias Cristina Nuñez-Diaz Raquel Sanchez-Varo Elena Galea JoséC Davila Marisa Vizuete Antonia Gutierrez Javier Vitorica 杜一星(编译) | 2021 | 神经损伤与功能重建2021，16，5： | 0 |
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