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| 1 | Reduction of Cancer Risk With an Oral Supplement of Selenium显示文摘The hypothesis that a dietary Supplement of selenium (Se) may reduce cancer risk was tested experimetally in humans. Patients with histories of basal/squarnous cell carcinomas of the skin were assigned randomly in double-blind fashion to dally oral supplements of either Seenriched yeast (200 μg Se/day), or a low-Se yeast placebo. A total of 1312 patients recruited in 1983-1990 were followed with regular dermatologic examinations through 1993 for a total of 8269 person-years of observation. Skin cancer diagnoses were confirmed histologically.Plasma Se concentration was determined at 6-12 months intervals. All deaths and patient-reported illnesses were recorded; reported cancers were confirmed and documented by consultation with the patient medical care providers. The results indicate that Se did not significantly affect the primary endpoints: incidences of recurrent basal/squarnous cell carcinomas of the skin. However, Setreatment was associated with reductions in several secondary endpoints:total mortality, mortality from all cancers combined, as well as the incidence of all cancers combined, lung cancer, colorectal cancer and prostate cancer. The consistencies of these associations over time, between study clinics and for the leading cancer sltes strongly suggests benefits of Se-supplementation for this cohort of patients, supporting the hypopthesis that supplemental Se can reduce cancer risk. Although Se did no shown protective effects against nonmelanoma skin cancers, the suggested reductions in risks to other frequent cancers demand further evaluation in well controlled cliflical intervention | G·F·COMBSJR L·C·CLARK 等 | 1997 | Biomedical and Environmental Sciences1997，10，2： | 21 |
| 2 | 母猪难产的应对措施显示文摘当今猪生产系统中母猪难产并不常见,所占比例不到1%。母猪临近分娩时,大约每隔30~60分钟需进行产前观察。如果清楚母猪正常分娩过程,母猪出现难产时可第一时间采取相关措施。分娩前要保证分娩环境清洁和干燥(图1);预产期前1~5天将妊娠母猪赶往分娩栏(图2)。 | Singleton W Amass S F Clark L K 朱勇文 | 2012 | 养猪2012，，1： | 4 |
| 3 | Origin and subset distribution of peripheral blood dendritic cells in patients with chronic graft versus-host disease 显示文摘 | CLARK F J FREEMAN L DZIONEK A | 2003 | Transplantation2003，75，： | 1 |
| 4 | The contributions of lesion laterality and lesion volume to decision-making impairment follwing frontal lobe damage显示文摘 | Clark L Manes F Antoun N | 2003 | Neuropsychologia2003，41，11： | 1 |
| 5 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 6 | Luminescence dating of loess from the Liujiapo section, central China显示文摘 | Musson F M Clarke M L Wintle A G | 1994 | Quaternary Science Reviews1994，13，： | 1 |
| 7 | Isolation of the gene encoding an immunodominant membrane pro- tein of apple proliferation phytoplasma, and expression and characterization of the gene product 显示文摘 | BERG M DAVIES D L CLARK M F | 1999 | Microbi- ology1999，145，： | 1 |
| 8 | Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure显示文摘 | Clark L C Jr Gollan F | 1966 | Science1966，152，3730： | 1 |
| 9 | Andesite and dacite genesis via contrasting processes: The geology and geochemistry of El Valle Volcano, Panama显示文摘 | DEFANT M J CLARK L F STEWART R H | 1991 | Contrib Mineral Petrol1991，106，： | 1 |
| 10 | Maintenance of mycoplasma-like organisms occurring in Pyras species by micropropagatin and their eliminatin by tetracycline therapy 显示文摘 | DAVIES D L CLARK M F | 1994 | Plant pathology1994，43，4： | 1 |
| 11 | The effects of small-dose ketamine on propofol sedation: respiration, postoperative mood, perception,cognition, and pain显示文摘 | MORTERO R F CLARK L D TOLAN M M | 2001 | Anesthesia & Analgesia2001，92，6： | 1 |
| 12 | OptDesign : extending optimizable K-dissimilarity selection for use in combinatorial library design 显示文摘 | Soltanshahi F Akella L Clark R D | 2003 | Journal of Chem Inf Computer Science2003，43，3： | 1 |
| 13 | Stem cells, cancer, and cancer stem cells显示文摘 | Reya T Morrison S J Clarke M F Weissman I L | 2001 | Nature2001，414，： | 1 |
| 14 | Stem cells, cancer, and cancer stem cells显示文摘 | Reya T Morrison S J Clarke M F Weissman I L | 2001 | Nature2001，414，： | 1 |
| 15 | Intercomparison of internal proportional gas counting of ^85Kr and ^3H 显示文摘 | MAKEPEACE J L CLARK F E PICOLO J L | 1994 | Nuclear Instru- ments and Methods in Physics Research A1994，339，： | 1 |
| 16 | A comparison ofsteady - state evoked potentials to modulated tones inawaked and sleeping humans 显示文摘 | Cohen L T Rickards F W Clark G M | 1991 | J Acoust Soc Am1991，90，5： | 1 |
| 17 | Consumer Complaints:Advice on How Companies Should Respond Based on an Empirical Study 显示文摘 | CLARK G L KAMINSKI P F RINK D R | 1992 | Journal of Services Marketing1992，6，1： | 1 |
| 18 | Detection and characterization of the hemolysin genes in Aeromonas hydrophila and Aeromonas sobria by multiplex PCR显示文摘 | Wang G Clark C G Liu C Y Pucknell C Munro C K Kruk T M A C Caldeira R Woodward D L Rodgers F G | 2003 | J Clin Microbiol2003，41，3： | 1 |
| 19 | Cyclic AMP and acidic fibroblast growth factor have opposing effects on tight and adherens junctions in microvascular endothelial cells in vitro显示文摘 | Dye J F Leach L Clark P | 2001 | Microvasc Res2001，62，2： | 1 |
| 20 | Aero-optic performance of supersonic mixing layers显示文摘 | Lawson S M Clark R L Crouse R F | 1990 | Proceedings of SPIE1990，1326，： | 1 |
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