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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Digoxin:A systematic review in atrial fibrillation,congestive heart failure and post myocardial infarction显示文摘AIM: To review digoxin use in systolic congestive heart failure, atrial fibrillation, and after myocardial infarction. METHODS: A comprehensive Pub Med search was performed using the key words 'digoxin and congestive heart failure', 'digoxin and atrial fibrillation', 'digoxin, atrial fibrillation and systolic congestive heart failure', and 'digoxin and myocardial infarction'. Only articles written in English were included in this study. We retained studies originating from randomized controlled trials, registries and included at least 500 patients. The studies included patients with atrial fibrillation or heart failure or myocardial infarction and had a significant proportion of patients(at least 5%) on digoxin. A table reviewing the different hazard ratios was developed based on the articles selected. Our primary endpoint was the overall mortality in the patients on digoxin vs those without digoxin, among patients with atrial fibrillation and also among patients with atrial fibrillation and systolic heart failure. We reviewed the most recent international guidelines to discuss current recommendations.RESULTS: A total of 18 studies were found that evaluated digoxin and overall mortality in different clinical settings including systolic congestive heart failure and normal sinus rhythm(n = 5), atrial fibrillation with and without systolic congestive heart failure(n = 9), and myocardial infarction(n = 4). Overall, patients with systolic congestive heart failure with normal sinus rhythm, digoxin appears to have a neutral effect on mortality especially if close digoxin level monitoring is employed. However, most of the observational studies evaluating digoxin use in atrial fibrillation without systolic congestive heart failure showed an increase in overall mortality when taking digoxin. In the studies evaluated in this systematic review, the data among patients with atrial fibrillation and systolic congestive heart failure, as well as post myocardial infarction were more controversial. The extent to which discrepancies among studies are based on statistical methods is currently unclear, as these studies' findings are generated by retrospective analyses that employed different techniques to address confounding. CONCLUSION: Based on the potential risks and benefits, as well as the presence of alternative drugs, there is a limited role for digoxin in the management of patients with normal sinus rhythm and congestive heart failure. Based on the retrospective studies reviewed there is a growing volume of data showing increased mortality in those with only atrial fibrillation. The pro-per role of digoxin is, however, less certain in other subgroups of patients, such as those with both atrial fibrillation and systolic congestive heart failure or after a myocardial infarction. Further studies may provide helpful information for such subgroups of patients. | Sebastiano Virgadamo Richard Charnigo Yousef Darrat Gustavo Morales Claude S Elayi | 2015 | World Journal of Cardiology2015，7，11： | 4 |
| 3 | Wnt signaling and hepatocarcinogenesis: molecular targets for the development of innovative anticancer drugs显示文摘 | Floriane Pez Ana?s Lopez Miran Kim Jack R. Wands Claude Caron de Fromentel Philippe Merle | 2013 | Journal of Hepatology2013，，： | 3 |
| 4 | Lobar torsion after pulmonary resection: Presentation and outcome显示文摘 | David S Claude D Mark S | 2001 | J Thorac Cardiovasc Surg2001，122，6： | 1 |
| 5 | An entropy based classification scheme for land applications of polarimetrie SAR 显示文摘 | Claude S R Pottier E | 1997 | IEEE Transactions on Geoseience and Remote Sensing1997，35，1： | 1 |
| 6 | Fiber-reinforced Polymer-confined Circular Concrete Columns: Investigation of Size and Slenderness Effects 显示文摘 | Theriault M Neale K W Claude S | 2004 | Journal of Composite for Construction2004，4，323： | 1 |
| 7 | IgE-binding epitopic peptide mapping on a three-dimensional model built for the 13S globulin allergen of buckwheat (Fagopyrum esculentum)显示文摘 | CAMILLE S RAPHAE C CLAUDE G | 2009 | Peptides2009，30，6： | 1 |
| 8 | Comparative evaluation of single-level closing-wedge vertebral osteotomies for the correction of fixed kyphotic deformity of the lumbar spine: a cadaveric study显示文摘 | Li F Claude S H Liu B | 2001 | Spine2001，26，21： | 1 |
| 9 | IgE-binding epitopic peptide mapping on a three dimensional model built for the 13S globulin allergen of buckwheat (Fagopyrum esculentum)显示文摘 | CAMILLE S RAPHAE C CLAUDE G | 2009 | Peptides2009，30，6： | 1 |
| 10 | Millimetre-wave broadband transition of substrate-integrated waveguide to rectangular waveguide 显示文摘 | Dousset D Wu K Claude S | 2010 | Electron Lett2010，46，24： | 1 |
| 11 | Design of a chimeric 3 - methyl - 1, 2, 3 - triazene with mixed receptor tyrosine kinase and DNA damaging properties: a morel tumor targeting strategy显示文摘 | Matheson S L Mcnamee J Jean - claude B J | 2001 | The Jourmal of Pharmacology and Experimental Therapeutics2001，296，3： | 1 |
| 12 | Localisation of drug permeability along the rat small intestine,using markers of the paracellular,transcellular and some transporter routes显示文摘 | OLIVIER L JOHN W CLAUDE S etal | 2004 | Eur J Pharn Sci2004，23，45： | 1 |
| 13 | Reliability and validity of the VSP - A : A health - related quality of life instrument for ill and healthy adolescents 显示文摘 | Christophe S Marie - Claude S | 2005 | Journal of Adolescent Health2005，6，3： | 1 |
| 14 | Dealing with globalisation at the regional and local level:The case of contemporary containerization显示文摘 | Robert J M Brian S Claude C | 2004 | The Canadian Geographer2004，48，4： | 1 |
| 15 | Benefit of glucocorticosteroid in the routine therapy of bacterial meningitis in children显示文摘 | Guillaume Sébire Claude Cyr Bernard Echenne | 2006 | European Journal of Paediatric Neurology2006，，4： | 1 |
| 16 | Ischemic Lacunar Stroke in Patients With and Without Potential Mechanism Other Than Small-Artery Disease 显示文摘 | Ralf WB Claude S Maria M | 2003 | Stroke2003，34，： | 1 |
| 17 | A metabolic study of the regulation of proteolysis by sugars in maize root tips: effects of glycerol and dihydroxyacetone显示文摘 | Renaud Brouquisse Dominique Rolin Sandra Cortès Monique Gaudillère Adeline Evrard Claude Roby | 2007 | Planta2007，，3： | 1 |
| 18 | Terrestrial xenology 显示文摘 | Thomas S Claude J A | 1982 | Earth and Planetary Science Letters1982，60，： | 1 |
| 19 | Interest of molecularly imprinted polymers in the fight against doping Extraction of tamoxifen and its main metabolite from urine followed by high-performance liquid chromatography with UV detection 显示文摘 | Claude B Morina P Bayoudhb S | 2008 | Journal of Chromatography A2008，81，88： | 1 |
| 20 | A Procedure for Surveying Personal Networks显示文摘 | CLAUDE S F | 1978 | Sociological Methods & Research1978，7，2： | 1 |
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