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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Highly sulfated dermatan sulfates from ascidiand: Structure versus anticoagulant activity of these glycosaminoglycans显示文摘 | Pavao Mauro S G Aiekko Karin R M Werneck Claudio C | 1998 | J Biol Chem1998，273，27： | 1 |
| 3 | Fast adaptive digital equalization by recurrent neural networks显示文摘 | PARISI R DI CLAUDIO E D ORLANDI G | 2007 | IEEE Transactions on Signal Processing2007，45，7： | 1 |
| 4 | Antioxidant capacities,carotenoids and polyphenols evaluation of fresh and refrigerated peach and nectarine cultivars from Italy显示文摘 | Claudio D V Giulia G Luigi M Annunziata C Alberto R | | 0，，： | 1 |
| 5 | Performance of modified montmorillonite clay in mercury adsorption process and thermodynamic studies显示文摘 | Denis L G Claudio A Rubia R V | 2008 | Inorganic Chemistry Communications2008，11，1： | 1 |
| 6 | Adsorption of mercury cation on chemically modified clay显示文摘 | Denis L G Rubia R V Claudio A | 2009 | Materials Research Bulletin2009，44，3： | 1 |
| 7 | Noninvasive in vivo quatitative assessment of fat conent in human liver显示文摘 | Renata L Eugenio G | 1997 | J Hepatol1997，27，1： | 1 |
| 8 | Antagonistic Effects of soybean viruses on Soybean Aphid Performance显示文摘 | CLAUDIO G | 2007 | Environmental Entomology2007，36，4： | 1 |
| 9 | Assessments of trabecular bone density at implant sites on CT images 显示文摘 | Rubelisa C G Claudio R L | 2008 | Oral Surg Oral Med Pathol Oral Radio Endod2008，105，2： | 1 |
| 10 | Fast adaptive digital equalization by recurrent neural networks 显示文摘 | PARISI R DI CLAUDIO E D ORLANDI G | 1997 | IEEE Transactions on Signal Processing1997，45，11： | 1 |
| 11 | Structural composi-tion and different anticoagulant activities of dermatan sulfates from theskin of four species of rays,Dasyatis ameircana,Dasyatis gutatta,Aetoba-tus narinari and Potamotrygon motoro显示文摘 | DELLIAS J M M ONOFRE G R CLAUDIO C | 2004 | Biochimie2004，86，： | 1 |
| 12 | Car plate recognition by neural networks and image processing显示文摘 | Parisi R Claudio E D D Lucarelli G | 1998 | Circuits and Systems1998，，3： | 1 |
| 13 | Car plate recognition by neural networks and image processing显示文摘 | Di Claudio E D Lucarelli G | 1998 | IEEE Proc on Iht Symp on Circuit and Systems1998，3，： | 1 |
| 14 | Quassinoids from Picrasma crenata显示文摘 | Claudio N Ferreira R Antonio G | 2003 | Nat Prod Res2003，17，3： | 1 |
| 15 | Expression of proinflammatory cytokines and their inhibitors during the course of spontaneous bacterial peritonitis显示文摘 | CLAUDIO R R FATIMA G FERNANDO D | 2001 | DigDis Sci2001，46，8： | 1 |
| 16 | Encoded Gbit/s digital communications with synchronized chaotic semiconductor lasers显示文摘 | Claudio A S D Colet R M P Fernandez G | 1999 | IEEE Quantum Electron1999，35，3： | 1 |
| 17 | Genetic diversity of phytophthora capsici isolates from pepper and pumpkin in Argentina 显示文摘 | Daniel G Julian R Claudio G | 2011 | The Mycological Society of America2011，，11： | 1 |
| 18 | The effect of chloride on the electro-oxidation of adsorbed CO on polycrystalline platinum electrodes显示文摘 | ANA L C ANGEL C CLAUDIO G R | 2003 | J Electroanal Chem2003，548，： | 1 |
| 19 | Fast adaptive digital equa-lization by recurrent neural networks显示文摘 | Parisi R Claudio E D Orlandi G | 1997 | IEEE Transactions on Signal Processing1997，45，11： | 1 |
| 20 | Antioxidant capacities, carotenoids and polyphenols evaluation of fresh and refrigerated peach and nectarine cultivars from Italy 显示文摘 | CLAUDIO D V GIULIA G LUIGI M ANNUNZIATA C ALBERTO R | 2008 | Eur Food Res Technol2008，227，： | 1 |
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