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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 3 | Procalcitonin and C-reactive protein during systemic inflammatory response syndrome,sepsis and organ dysfunction显示文摘 | Gian PC Claudio P Michael M | 2004 | Criti Care2004，8，4： | 1 |
| 4 | Heat recovery from Diesel engines:A thermodynamic comparison between Kalina and ORC cycle显示文摘 | Bombarda P Costante M I Pietra Claudio | 2010 | Appl Therm Eng2010，33，23： | 1 |
| 5 | Epigenetic information and estrogen receptor alpha expression in breast cancer 显示文摘 | Giacioti L Claudio P P Lopez M | 2006 | Oncologist2006，11，1： | 1 |
| 6 | Asymptotic periodicity for some evolution equations in Banach spaces显示文摘 | Agarwal R P Cuevas Claudio Soto H El-Gebeily M | | 0，，05： | 1 |
| 7 | Procalcitonin and C-reactive protein during systemic inflammatory response syndrome,sepsis and organ dysfunction显示文摘 | Gian PC Claudio P Michael M | 2004 | Critical Care2004，8，2： | 1 |
| 8 | Coutinho critical assessment of the formation of ionic-liquid-based aqueous two-phase systems in acidic media显示文摘 | CLAUDIO A F M FERREIRA A M SHAHRIARI S FREIRE M G JOAO A P | 2011 | J Phys Chem B2011，115，11： | 1 |
| 9 | Heat recov- ery from diesel engines: a thermodynamic comparison be- tween Kalina and ORC cycle 显示文摘 | BOMBARDA P COSTANTE M I CLAUDIO P | 2010 | Applied Thermal Engineer- ing2010，33，23： | 1 |
| 10 | Effects of annealing on the physicochemical properties of fermented cassava starch (polvilho azedo ) 显示文摘 | Anida M M Gomes Claudio E Mendes da Silva Nagila M P S Ricardo | 2005 | Carbohydrate Polymers2005，60，1： | 1 |
| 11 | Mutations in the retinoblastoma - related gene Rb2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus - mediated gene transter显示文摘 | CLAUDIO P P HOWARD C M PACILIO C | 2000 | Cancer Res2000，60，2： | 1 |
| 12 | Retinoblas- toma - related protein pRb2/p130 and suppression of tumor growth in vivo显示文摘 | HOWARD C M CLAUDIO P P GALLIA G L | 1998 | J Natl Cancer Inst1998，90，19： | 1 |
| 13 | Editorial : orbital radiotherapy for Graves' ophthalmopathy显示文摘 | Luigi B Claudio M Aldo P | 2004 | JCEM2004，89，1： | 1 |
| 14 | Functional analysis of pRb2/p130 interaction with cyclins 显示文摘 | CLAUDIO P P DE LUCA A HOWARD C M | 1996 | Cancer Res1996，56，9： | 1 |
| 15 | Management of Graves′ ophthalmopathy :Reality and perspectives 显示文摘 | Luigi B Aldo P Claudio M | 2000 | J Endocrine Rev2000，21，： | 1 |
| 16 | Graves' ophthalmopathy:a preventable disease? 显示文摘 | Luigi B Claudio M Aldo P | 2002 | Eur J Endoerinol2002，146，4： | 1 |
| 17 | Botanical origin and chemical composition of Brazilian propolis 显示文摘 | Yong K P Severino M A Claudio L A | 2002 | Food Chemistry2002，，50： | 1 |
| 18 | VOCs removal from waste gases: gas-phase bioreaetor for the abatement of hexane by Aspergillus niger 显示文摘 | Giorgia S Claudio P Daria F M | 2003 | Chemical Engineering Science2003，58，： | 1 |
| 19 | Genetic altera- tions disrupting the nuclear localization of the retinoblastoma - re- lated gene RB2/p130 in human tumor cell lines and primary tumors显示文摘 | CINTI C CLAUDIO P P HOWARD C M | 2000 | Cancer Res2000，60，2： | 1 |
| 20 | Fiber reinforced polymer shear strengthening of reinforced concrete beams with transverse steel reinforcement显示文摘 | CARLO P CLAUDIO M | 2002 | Journal of Composites for Construction2002，6，2： | 1 |
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