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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Energetic-protein supplementation in the last 60 days of gestation improves performance of beef cows grazing tropical pastures显示文摘Background: Nutrition is one of the most important factors that affect animal performance, and it therefore also impacts on financial results in beef systems. In this way, finding the best strategy for feeding supplements is of paramount importance. Aiming to evaluate the effect of supplement feeding strategies for beef cows in the last third of gestation, two experiments were conducted. In Experiment 1, 35 pregnant Nellore cows were assigned to a completely randomized design with four treatments: control, which received no supplement; supplementation for the last 30 d of gestation(30-d; 3.0 kg/d); supplementation for the last 60 d of gestation(60-d; 1.5 kg/d); or supplementation for the last 90 d of gestation(90-d; 1.0 kg/d). All supplemented treatments received the same total amount of supplement throughout the experiment: 90 kg(20% of crude protein). A second experiment(Experiment 2) was delineated to evaluate the effects of the amounts offered in Experiment 1 on intake and metabolism. Four multiparous pregnant Nellore cows were assigned to a 4 × 4 Latin square design, with periods of15 d each.Results: There was a linear effect of the number of days of supplementation on calving body weight(BW; P < 0.05)and a quadratic effect on BW change from parturition to d 31 post-calving(P < 0.05), with cows on the 60-d strategy losing less BW post-calving. No difference was found in offspring birth BW(P > 0.10). A significant linear effect on interval from parturition to conception(P < 0.05) was observed, with the highest calving to conception interval being observed in the 90-d strategy. The level of supplementation did not affect forage intake or neutral detergent fiber digestibility(P > 0.10). Nitrogen excreted through urine tended to increase linearly with the level of supplementation(P < 0.10).Conclusion: Providing 1.5 kg of supplement during the last 60 d of gestation improves cow performance after calving, reducing the magnitude of BW lost, and reduces the number of days from calving to re-conception in the following breeding season compared to the usually recommended period of supplementation of 90 d pre-partum. | Aline Gomes da Silva Mário Fonseca Paulino Edenio Detmann Henrique Jorge Fernandes Lincoln da Silva Amorim Román Enrique Maza Ortega Victor Valério de Carvalho Josilaine Aparecida da Costa Lima Felipe Henrique de Moura Mariana Benevides Monteiro Jéssika Almeida Bitencourt | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 2 |
| 3 | Effect of ausforming on microstructure and hardness of AISI H13 tool steel modified with niobium显示文摘 | Elias C N and Costa Viana C S Da | 1992 | Materials Science and Technology1992，9，： | 1 |
| 4 | Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties显示文摘 | PONTI D COSTA A ZAFFARONI N | 2005 | Cancer Res2005，65，13： | 1 |
| 5 | Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties显示文摘 | Ponti D Costa A Zaffaroni N Pratesi G Petrangolini G Coradini D | 2005 | Cancer Res2005，65，： | 1 |
| 6 | Does teaching style matter? A randomised trial of group discussion versus lectures in orthopaedic undergraduate teaching显示文摘 | COSTA M L RENSBURG RUSHTONL N | 2007 | Medical Education2007，41，： | 1 |
| 7 | Molecular andphysiological role of the trehalose-hydrolyzing alpha-glucosidase from Thermus thermophilus HB27 显示文摘 | Alarico S Costa MS Empadinhas N | 2008 | J Bacteriol2008，190，7： | 1 |
| 8 | Muta- tion of the PIK3CA gene in anaplastic thyroid cancer显示文摘 | Garc I a-Rost 6 n G Costa AM Pereira-Castro I | 2005 | Can- eer Res2005，65，10： | 1 |
| 9 | Rapid diagnosis of acute promyelocytic leukemia by analyzing the immunocytochemical pattern of the PML protein with the monoclonal antibody PG-M3 显示文摘 | Villamor N Costa D Aymerich M | 2000 | Am J Clin Pathol2000，114，： | 1 |
| 10 | HincⅡand Hae ⅢRFLPs in the porcine mtDNA D-loop region显示文摘 | Davoli R Costosi E Nanni Costa L N | 1995 | Anim Genet1995，26，3： | 1 |
| 11 | Experimental evaluation of the structural response of perfobond shear connectors显示文摘 | CANDIDO M COSTA N PCGDAS V | 2010 | Engineering Structures2010，32，： | 1 |
| 12 | Polyamine metabolism as related to fruit set and growth显示文摘 | Biasi R Costa G Bagni N | 1991 | Plant Physiology and Biochemistry1991，29，5： | 1 |
| 13 | Water-deficit-responsive proteins in maritime pine显示文摘 | COSTA P BAHRMAN N FRIGERIO J M | 1998 | Plant Mol Biol1998，38，4： | 1 |
| 14 | Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties显示文摘 | Ponti D Costa A Zaffaroni N | | 0，，13： | 1 |
| 15 | Survivin is high- lyexpressed and promotes cell survival in malignant peritoneal mes- othelioma显示文摘 | ZAFARON1 N COSTA A PENNATI M | 2007 | Cell Oncol2007，29，6： | 1 |
| 16 | Calcineurin differentially regulates fast myosin heavy chain genes in oxidative muscle frbre type conversion显示文摘 | da Costa N Edgar J Ooi PT | 2007 | Cell Tissue Res2007，329，3： | 1 |
| 17 | Potassium-use efficiency in common bean genotypes 显示文摘 | FAGERIA N K BARBOSA COSTA M P | 2001 | Journal of Plant Nutrition2001，24，12： | 1 |
| 18 | 显示文摘 | Belessi V C Costa C N Bakas T V | 2000 | Catal Today2000，59，： | 1 |
| 19 | Study of the nozzle flow in a cross-flow turbine显示文摘 | Costa Pereira N H Borges J E | 1996 | International Journal of Mechanical Siciences1996，38，3： | 1 |
| 20 | Mathematical modeling of the oxygen storage capacity phenomenon studied by CO pulse transient experiments over Pd/CeO2 catalyst显示文摘 | COSTA C N CHRISTOU S Y GEORGIOU G | 2003 | Journal of Catalysis2003，219，： | 1 |
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