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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Characteristics of allergic colitis in breast-fed infants in the absence of cow's milk allergy显示文摘AIM: To investigate the characteristics of mucosal le-sions and their relation to laboratory data and long-term follow up in breast-fed infants with allergic colitis. METHODS: In this study 31 breast-fed infants were prospectively evaluated (mean age, 17.4 wk) whose rectal bleeding had not ceased after a maternal elimi-nation diet for cow's milk. Thirty-four age-matched and breast-fed infants (mean age, 16.9 wk) with no rectal bleeding were enrolled for laboratory testing as con-trols. Laboratory findings, colonoscopic and histological characteristics were prospectively evaluated in infants with rectal bleeding. Long-term follow-up with differ-ent nutritional regimes (L-amino-acid based formula or breastfeeding) was also included. RESULTS: Iron deficiency, peripheral eosinophilia andthrombocytosis were significantly higher in patients with allergic colitis in comparison to controls (8.4±3.2 μmol/L vs 13.7±4.7 μmol/L, P<0.001; 0.67±0.49 G/L vs 0.33±0.17 G/L, P<0.001; 474±123 G/L vs 376±89 G/L, P<0.001, respectively). At colonosco-py, lymphonodular hyperplasia or aphthous ulceration were present in 83% of patients. Twenty-two patients were given L-amino acid-based formula and 8 contin-ued the previous feeding. Time to cessation of rectal bleeding was shorter in the special formula feeding group (mean, 1.4 wk; range, 0.5-3 wk) when com-pared with the breast-feeding group (mean, 5.3 wk; range, 2-9 wk). Nevertheless, none of the patients ex-hibited rectal bleeding at the 3-mo visit irrespective of the type of feeding. Peripheral eosinophilia and cessa-tion of rectal bleeding after administration of elemental formula correlated with a higher density of mucosal eosinophils. CONCLUSION: Infant hematochezia, after cow's milk allergy exclusion, is generally a benign and probably self-limiting disorder despite marked mucosal abnor-mality. Formula feeding results in shorter time to cessa-tion of rectal bleeding; however, breast-feeding should not be discouraged in long-lasting hematochezia. | Kriszta Molnár Petra Pintér Hajnalka Gyrffy ron Cseh Katalin Eszter Müller András Arató Gábor Veres | 2013 | World Journal of Gastroenterology2013，19，24： | 3 |
| 3 | Vitamin D and estrogen receptorgene polymorphisms in type 2 diabetes mellitus and in android type o-besity显示文摘 | Speer G Cseh K Winkler G | 2001 | Eur J Endocrinol2001，144，4： | 1 |
| 4 | Tumor necrosis factor system in insulin resistence in gestational diabetes显示文摘 | Winker G Cseh K Baranyi E | 2002 | Diabetes Res Cliff Pract2002，56，2： | 1 |
| 5 | Molecular mechanisms and correlations of insulin resistance,obesity,and type 2 diabetes mellitus显示文摘 | Winkler G Cseh K | | 0，，17： | 1 |
| 6 | Matrix metalloproteinase inhihitors: a critical appraisal of design principles and pro- posed therapeutic utility显示文摘 | Dorman G Cseh S Hajdu I | 2010 | Drugs2010，70，： | 1 |
| 7 | Effect of 3 months of doxazosin therapy on T-cell subsets in type 2 diabetic patients显示文摘 | Macsai E Cseh A Budai G | 2009 | lnt Med Res2009，37，6： | 1 |
| 8 | Matrix Metalloproteinase Inhibitors A Critical Appraisal of Design Principles and Proposed Therapeutic Utility显示文摘 | Dorman G Cseh S Hajdu I | 2010 | Drugs2010，70，8： | 1 |
| 9 | The role of Tumor necrosis factor(TNF)-α resistance in obesity and insulin resistance显示文摘 | Winkler G Cseh K Baranyi E | 2000 | Diabetologia2000，43，： | 1 |
| 10 | Indentation curves and viscosity measurements on glasses显示文摘 | CSEH G CHINH N JUHASZ A | 1998 | Journal of Materials Science Let ters1998，17，14： | 1 |
| 11 | Indentation test for the investigation of high temperature plasticity of materials显示文摘 | CSEH G CHINH N TASNADI P | 1997 | Journal of Materials Science1997，32，19： | 1 |
| 12 | Matrix metalloproteinase inhibitors a critical appraisal of design principles and proposed therapeutic utility 显示文摘 | DORMAN G CSEH S HAJDU I | 2010 | Drugs2010，70，8： | 1 |
| 13 | Molecular mechanisms and correlations of insulin resistance, obesity, and type 2 diabetes mellitus显示文摘 | Winkler G Cseh K | 2009 | Orv Hetil2009，150，17： | 1 |
| 14 | Indentation creep in a short fibre-reinforced metal matrix composite显示文摘 | G Cseh J B?r H.-J Gudladt J Lendvai A Juhász | 1999 | Materials Science & Engineering A1999，，1： | 1 |
| 15 | Chronic stress decreases the number of parvalbumin-immunorcactive interneurons in the hippoeampus:prevention by treatment with a substance P receptor (NK1) antagonist显示文摘 | Cseh B Simon M van derHart M G | 2005 | Neuropsychopharmacology2005，30，1： | 1 |
| 16 | Tumor necrosis factor system in insulin resistance in gestational diabetes 显示文摘 | Winkler G Cseh K Baranyi E | 2002 | Diabetes Res Clin Pract2002，56，2： | 1 |
| 17 | Assisted reproductive technologies in the reproductive management of small ruminants 显示文摘 | Amiridis G S Cseh S | 2012 | Anim Reprod Sci2012，130，34： | 1 |
| 18 | Molecular mechanisms and correlations of insulin resistance,obesity,and type 2 diabetes mellitus显示文摘 | Winkler G Cseh K | | 0，，17： | 1 |
| 19 | The role of Tumor necrosis factor(TNF)-α resistance in obesity and insulin resistance显示文摘 | Winkler G Cseh K Baranyi E | 2000 | Diabetologia2000，43，： | 1 |
| 20 | Effect of 3 months of doxazosin therapy on T-cell subsets in type 2 diabetic patients显示文摘 | Mácsai E Cseh A Budai G Mészáros G Vásárhelyi B Fischer K Szabó A Treszl A | 2009 | J Int Med Res2009，37，6： | 1 |
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