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| 1 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 2 | Relapsing polychondritis with p-ANCA associated vasculitis: Which triggers the other?显示文摘Relapsing polychondritis(RP) is a rare autoimmune disease with chronic inflammatory/destructive lesions of the cartilaginous tissues. In one third of the cases it is associated with other autoimmune disorders, mostly with anti-neutrophil cytoplasmic antibody(ANCA) associated vasculitis(AAV). We report three cases of RP with p-ANCA positive AAV. In the first patient RP developed 1.5 years after the onset of AAV. In the others the signs of RP were present before the onset of severe crescent glomerulonephritis. Patients responded well on steroid and cyclophosphamide. In dialysis dependent cases plasmapheresis was also used successfully. During the 2 and 1.5 years of follow up, they were symptom-free, and had stable glomerular filtration rate. The first patient died after four years of follow-up due to the complications of sudden unset pancytopenia,which raises the possibility of associated hemophagocytic syndrome. In the setting of RP or AAV physicians should always be aware of the possibility of sudden or insidious appearance of the other disease. | Ibolya File Csilla Trinn Zsolt Mátyus László Ujhelyi József Balla János Mátyus | 2014 | World Journal of Clinical Cases2014，2，12： | 1 |
| 3 | SJES14110700244508显示文摘 | Csilla Müller Leontin David Vasile Chi? Simona Cint? P?nzaru | 2014 | Food Chemistry2014，，： | 1 |
| 4 | Evahatlon of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the breast cancer linkage consortium显示文摘 | Csilla IS Jon M | 2002 | PANAS2002，99，2： | 1 |
| 5 | Heteropoly Acids Immobilized into A Sillica Matrix : Characterization and Catalytic Applications 显示文摘 | Arpat M Csilla K Brla T | 1999 | Appl Catal A : Gen1999，189，6： | 1 |
| 6 | Application of a yeast estrogen reporter system for screening zearalenone degrading microbes显示文摘 | Csilla Krifaton Balázs Kriszt Anita Risa Sándor Szoboszlay Mátyás Cserháti Péter Harkai Melanie Eldridge Jun Wang József Kukolya | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 7 | The will-o'-the-wisp of genetics-hunting for the azoospermia factor gene显示文摘 | Chris T S Csilla K M D | | 0，，： | 1 |
| 8 | Guanine-cytosine rich regions of plasmid DNA can be the target in antiplasmid effect of phenothiazines显示文摘 | CSILLA M IMRE L TERUO K NOBORU M JOSEPH M | 2000 | Int J Antimicrob Ag2000，14，： | 1 |
| 9 | Copper impairs biliary epithelial cells and induces proteha oxidation and oxidative DNA damage in the isolated perfused rat liver 显示文摘 | Albena A Anton K Csilla M | 2007 | Experimental and Toxicologic Pathology2007，58，4： | 1 |
| 10 | Prevalence of SLC22A4 1672T and SLC22A5 ?207C combination defined TC haplotype in Hungarian ulcerative colitis patients显示文摘 | Lili Magyari Judit Bene Katalin Komlósi Gábor Talián Bernadett Faragó Veronika Cs?ngei Luca Járomi Enik? Sáfrány Csilla Sipeky Lilla Lakner Márta Varga Beáta Gasztonyi Béla Melegh | 2007 | Pathology & Oncology Research2007，，1： | 1 |
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