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| 1 | Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial显示文摘 | Martijn HGM van der Pas Eva Haglind Miguel A Cuesta Alois Fürst Antonio M Lacy Wim CJ Hop Hendrik Jaap Bonjer | 2013 | Lancet Oncology2013，，： | 17 |
| 2 | Elastic band ligation of hemorrhoids:Flexible gastroscope or rigid proctoscope?显示文摘AIM: To compare rigid proctoscope and flexible endoscope for elastic band ligation of internal hemorrhoids. METHODS: Patients between 18 and 80 years old, with chronic complaints (blood loss, pain, itching or prolapse) of internal hemorrhoids of grade I-Ⅲ, were randomized to elastic band ligation by rigid proctoscope or flexible endoscope (preloaded with 7 bands). Patients were re- treated every 6 wk until the cessation of complaints. Evaluation by three-dimensional anal endosonography was performed. RESULTS: Forty-one patients were included (median age 52.0, range 27-79 years, 20 men). Nineteen patients were treated with a rigid proctoscope and twenty two with a flexible endoscope. Twenty-nine patients had grade I hemorrhoids, 9 patients had grade Ⅱ hemorrhoids and 3 patients had grade Ⅲ hemorrhoids. All patients needed a minimum of 1 treatment and a maximum of 3 treatments. A median of 4.0 bands was used in the rigid proctoscope group and a median of 6.0 bands was used in the flexible endoscope group (P < 0.05). Pain after ligation tended to be more frequent in patients treated with the flexible endoscope (first treatment: 3 vs 10 patients, P < 0.05). Three- dimensional endosonography showed no sphincter defects or alterations in submucosal thickness. CONCLUSION: Both techniques are easy to perform, well tolerated and have a good and fast effect. It is easier to perform more ligations with the flexible endoscope. Additional advantages of the flexible scope are the maneuverability and photographic documentation. However, treatment with the flexible endoscope might be more painful and is more expensive. | M Cazemier RJF Felt-Bersma MA Cuesta CJJ Mulder | 2007 | World Journal of Gastroenterology2007，13，4： | 12 |
| 3 | Antibody engineering: facing new challenges in cancer therapy显示文摘Antibody-based therapeutics are beginning to realize the promise enclosed in their early denomination as “magic bullets”. Initial disappointment has turned into clinical and commercial success, and engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials. Recent structural and functional data have allowed the design of a new generation of therapeutic antibodies, with strategies ranging from complement-mediated and antibody-dependant cellular cytotoxicity enhancement to improved cytotoxic payloads using toxins, drugs,radionucleids and viral delivery. This review considers the structure of different types of recombinant antibodies, their mechanism of action and how their efficacy has been increased using a broad array of approaches. We will also focus on the additional benefits offered by the use of gene therapy methods for the in vivo production of therapeutic antibodies. | Laura S■NZ ■ngel M CUESTA Mana COMPTE Luis ■LVAREZ-VALLINA | 2005 | Acta Pharmacologica Sinica2005，26，6： | 5 |
| 4 | 维生素C和维生素E减轻热应激改善蛋鸡活质量和蛋品质显示文摘试验为研究维生素C和维生素E对热应激下蛋鸡活质量和蛋品质的影响。试验选用720羽39周龄白莱航蛋鸡,随机分为4个处理组,各组分别添加0、150 mg/kg维生素C、150 mg/kg(150 IU)维生素E和150 mg/kg维生素C+150 mg/kg维生素E。试验结束时各试验组的最终活质量、蛋质量、蛋黄质量、蛋清质量和蛋壳质量都显著高于对照组(P<0.05),其中添加维生素C+维生素E组的蛋壳质量最高。通过对蛋鸡活质量和蛋品质指标的跟踪观察发现,抗氧化添加剂的加入能缓解热应激造成的不良影响。 | J J Ajakaiye M Cuesta - Mazorra J R Garcia - Diaz 黄鑫 李彪 谭斌 | 2013 | 饲料研究2013，36，7： | 3 |
| 5 | 高血压患者肾素血管紧张素系统阻断的血浆分子标志:肾损害与初发蛋白尿的新预测指标显示文摘蛋白尿是一个与心血管病密切相关的危险因素,也是一般人群的首位死亡原因。虽然已经明确肾素血管紧张素系统(renin-angiotensin system,RAS)阻断剂能延缓高血压患者初发蛋白尿进展、减少蛋白尿排出,但仍不能忽视高血压患者发生初发蛋白尿的比例。 | Baldan-Martin M Mourino-Alvarez L Gonzalez-Calero L Moreno-Luna R Sastre-Oliva T Ruiz-Hurtado G Segura J Lopez JA Vazquez J Vivanco F Alvarez-Llamas G Ruilope LM de la Cuesta F Barderas MG 赵狄 练桂丽 | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 6 | Toll-like receptors, in- flammation, metabolism and obesity 显示文摘 | Fresno M Alvarez R Cuesta N | 2011 | Arch Physiol Bio- chem2011，117，： | 1 |
| 7 | Control of the chemical structure of perhydrous coals : FTIR and Py-GC/MS investigation显示文摘 | IGLESIAS M J del RIIO J C LAGGOUN-D FARGE F CUESTA M J SU REZ-RUIZ I | 2002 | J Anal Appl Pyrolysis2002，62，1： | 1 |
| 8 | Assymetric Eigenvalue Problems with Weights显示文摘 | ARIAS M CAMPOS J CUESTA M | 2001 | CRAST2001，332，1： | 1 |
| 9 | Structure of Tars Derived from Low-Temperature Pyrolysis of Pure Vitrinites: Influence of Rank and Composition of Vitrinites 显示文摘 | Iglesias M J Cuesta M J Suarez-Rui I | 2001 | J Anal Appl Pyrol2001，59，2： | 1 |
| 10 | Neonatal diabetes mellitus due to complete glucokinase deficiency 显示文摘 | Njolstad P R Sovik O Cuesta M A | 2001 | N Engl J Med2001，344，： | 1 |
| 11 | Fatal infection due to Haemophilus parasuis in a young wild boar (Sus scrofa)显示文摘 | Cuesta Gerveno J M Risco Perez D Goncalves Blanco P | 2013 | J Vet Diagn Invest2013，25，2： | 1 |
| 12 | Single- incision versus conventional laparoscopic cholecystectomy: a case control study 显示文摘 | van den Boezem P B Kruyt P M Cuesta M A | 2012 | Acta Chir Belg2012，112，5： | 1 |
| 13 | Use of gene therapy in a subcutaneous murine model of lung cancer 显示文摘 | Rodrigo Garzon M Tirapu Femondez de la Cuesta I Arina Iraeta A | 2006 | Arch Bronconeumol2006，42，10： | 1 |
| 14 | Dietary administration of Lactobacill delbrueckii and Bacillus subtilis,single or combined,on gilthead seabream cellular innate immune responses显示文摘 | Salinas I Cuesta A Esteban M A | 2005 | Fish andShellfish Immunology2005，19，1： | 1 |
| 15 | Dietary administration of Lactobaeillus del- bmeckii and Bacillus subtilis,single or combined, on gilthead seabream cellular innate immune responses显示文摘 | Salinas I Cuesta A Esteban M | 2005 | Fish Shellfish Immunol2005，19，： | 1 |
| 16 | Press archives as temporal records of landslides in the North of Spain: relationships between rainfall and instability slope events显示文摘 | Cuesta M J Sanchez M J Garcia A R | 1999 | Geomorphology1999，30，： | 1 |
| 17 | Organochlorine and heavy metal residues in the water/sediment system of the Southeast Regional Park in Madrid, Spain显示文摘 | Fernandez M Cuesta S Jimenez O Garcia M A Hernandez L M Marina M L Gonzalez M J | 2000 | Chemosphere2000，41，： | 1 |
| 18 | Phase transition in two-dimensional traffic model显示文摘 | Cuesta J A Martinez F C Molerea J M | 1993 | Phys Rev1993，48，6： | 1 |
| 19 | Molecular and functional characterization of the gilthead seabream Ⅱ-defensin demonstrate its chemotactic andantimicrobial activity显示文摘 | CUESTA A MESEGUER J ESTEBAN M A | 2011 | Mol Immunoh2011，48，1213： | 1 |
| 20 | Minimally invasive versus open esophagectomy for cance: a systematic review and meta-analysis显示文摘 | Biere S S Cuesta M A Vander D L | 2009 | Minerva Chirurgica2009，64，2： | 1 |
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