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| 1 | 中国妇女妊娠前后单纯服用叶酸对神经管畸形的预防效果显示文摘目的 评价妇女在妊娠前后服用单纯 40 0 μg叶酸增补剂对胎 /婴儿神经管畸形 (NTDs)的预防效果。方法 1993~ 1995年在中国北方的NTDs高发地区和南方的NTDs低发地区妇女增补叶酸的推广项目中 ,共募集从孕前或孕后任何时间开始服药的妇女 130 142名 ,未服药的妇女 1176 89名 ;设计的服药方法从婚检时开始到孕满 3个月为止 ,每天服用单纯叶酸片 40 0 μg ;最后对妇女的分娩结局进行监测并进行预防效果的对比评价研究。结果 服药组妇女生育的胎婴儿中共发现 10 2例NTDs ,对照组胎婴儿中共发现 173例NTDs。末次月经前募集的未服药妇女在孕 2 0周以后分娩的胎婴中NTDs发生率 ,北方为 4 8‰ (16 / 3 318) ,南方为 1 0‰ (2 8/ 2 82 6 5 ) ,而妊娠前后服药妇女组则分别为1 0‰ (13/ 13 0 12 )和 0 6‰ (34/ 5 86 38)。与末次月经前募集的未服药妇女组相比 ,北方服药妇女NTDs发生率明显降低 ,其中依从性大于 80 %的服药组妇女预防率达 85 % (95 %CI为 6 2 %~ 94% ) ,南方地区服叶酸的预防率为 41% (95 %CI为 3 %~ 6 4% )。结论 妇女在妊娠前后每天服用单纯叶酸 40 0 | 李竹 RobertJ Berry 李松 J David Erickson 王红 Cynthia A Moore 赵平 Joseph Mulinare 洪世欣 Lee-Yang C Wong 呼和牧人 Jacqueline Gindler 郝玲 Adolfo Correa 朱慧萍 Elaine Gunter | 2000 | 中华医学杂志2000，80，7： | 185 |
| 2 | Subcutaneous Golimumab Induces Clinical Response and Remission in Patients with Moderate-To-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Brian G. Feagan Colleen Marano Hongyan Zhang Richard Strauss Jewel Johanns Omoniyi J. Adedokun Cynthia Guzzo Jean-Frederic Colombel Walter Reinisch Peter R. Gibson Judith Collins Gunnar J?rnerot Toshifumi Hibi Paul Rutgeerts | 2013 | Gastroenterology2013，，： | 6 |
| 3 | Subcutaneous Golimumab Maintains Clinical Response in Patients with Moderate-To-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Brian G. Feagan Colleen Marano Hongyan Zhang Richard Strauss Jewel Johanns Omoniyi J. Adedokun Cynthia Guzzo Jean-Frederic Colombel Walter Reinisch Peter R. Gibson Judith Collins Gunnar J?rnerot Paul Rutgeerts | 2013 | Gastroenterology2013，，： | 5 |
| 4 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 5 | Mechanical valve obstruction:Review of diagnostic and treatment strategies显示文摘Prosthetic valve obstruction(PVO) is a rare but feared complication of mechanical valve replacement. Diagno-stic evaluation should focus on differentiating prosthetic valve thrombosis(PVT) from pannus formation,as their treatment options differ. History of sub-optimal anti-coagulation and post-op time course to development of PVO are useful clinical characteristics in differentiating thrombus from pannus formation. Treatment of PVT is influenced by the patient's symptoms,valve location,degree of obstruction and thrombus size and may include thrombolysis or surgical intervention. Alternatively,pannus formation requires surgical intervention. The purpose of this article is to review the pathophysiology,epidemiology,diagnostic approach and treatment options for aortic and mitral valve PVO. | Jason Salamon Jerson Munoz--Mendoza Jared J Liebelt Cynthia C Taub | 2015 | World Journal of Cardiology2015，7，12： | 2 |
| 6 | Post‐liver transplantation sarcopenia in cirrhosis: A prospective evaluation显示文摘 | Cynthia Tsien Ari Garber Arvind Narayanan Shetal N Shah David Barnes Bijan Eghtesad John Fung Arthur J McCullough Srinivasan Dasarathy | 2014 | J Gastroenterol Hepatol2014，，6： | 2 |
| 7 | U- Pb zircon and geochemical evidence for bimodal mid-Paleozoic magmatism and syngenetic base-metal mineralization in the Yukon-Tanana terrane,Alaska显示文摘 | Cynthia D B Joseph L W Melanie J H | | 0，，7： | 1 |
| 8 | Intracostal sutures decrease the pain of thoracotomy显示文摘 | Robert J Cerfolio Theolynn N Price Ayesha S Bryant Cynthia Sale Bass Alfred A Bartolucci | 2003 | The Annals of Thoracic Surgery2003，，2： | 1 |
| 9 | Characterization Tests for Mineral Fillers Related to Performance of Asphalt Paving Mixtures显示文摘 | Prithvi S K Cynthia Y L Frazier P J | 1998 | NAPA Report1998，，2： | 1 |
| 10 | Maturation of the embryo, endosperm, and fruit of the dwarf mistletoe Arceuthobium americanum (Viscaceae) 显示文摘 | Cynthia M Ross F Michael J S | 2009 | J Plant Sci2009，170，3： | 1 |
| 11 | A case study of urban heat islands in the Carolinas显示文摘 | Vereda J K Cynthia D | 2007 | Environmental Hazards2007，7，4： | 1 |
| 12 | Letrozole in the neoadjuvant setting: the P024 trial显示文摘 | MATTHEW J CYNTHIA MA | 2007 | Breast Cancer Res Treat2007，105，1： | 1 |
| 13 | The efficacy of spinosad againstthe western flower thrips, Frankliniella occidentalis, and its impact on associated biological control agents on greenhouse cucumbers in southern Ontario显示文摘 | Terri J Cynthia S D Ron H | 2005 | Pest Management Science2005，61，： | 1 |
| 14 | Behavioral Interventions to Address Sleep Disturbances in Children with Autism Spectrum Disorders:A Review 显示文摘 | Kylan S T Cynthia R J | 2013 | Topics in Early Childhood Special Education2013，33，3： | 1 |
| 15 | Flow field in straight and t apered screw extruders using magnetic resonance imaging显示文摘 | Cynthia K A Kauten R J Mccarthy K L | 1995 | Jourhal of Food Engineering1995，25，1： | 1 |
| 16 | A Multilevel Examination of Work-Life Practices: Is More Always Better? 显示文摘 | Richard E Kopelman David J Prottas Cynthia A Thompson | 2006 | Journal of Managerial Issues2006，，2： | 1 |
| 17 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 18 | Elevated ErbB4 mRNA is related to interneuron deficit in prefrontal cortex in schizophrenia 显示文摘 | Dipesh J Janice MF Cynthia SW | 2014 | J Psychiat Res2014，53，1： | 1 |
| 19 | Mycoplasma pneumoniae Protein P30 Is Required for Cytadherence and Associated with Proper Cell Development显示文摘 | Cynthia E Susan J Melisa J | 1999 | Journal of Bacteriology1999，181，4： | 1 |
| 20 | Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western C?te d’Ivoire显示文摘 | Giovanna Raso Eliézer K N'Goran Abale Toty Anne Luginbühl Cynthia A Adjoua Norbert T Tian-Bi Isaac I Bogoch Penelope Vounatsou Marcel Tanner Jürg Utzinger | 2003 | Transactions of the Royal Society of Tropical Medicine and Hygiene2003，，1： | 1 |
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