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| 1 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Clinical applications of advanced magnetic resonance imaging techniques for arthritis evaluation显示文摘Magnetic resonance imaging(MRI) has allowed a comprehensive evaluation of articular disease, increasing the detection of early cartilage involvement, bone erosions, and edema in soft tissue and bone marrow compared to other imaging techniques. In the era of functional imaging, new advanced MRI sequences are being successfully applied for articular evaluation in cases of inflammatory, infectious, and degenerative arthropathies. Diffusion weighted imaging, new fat suppression techniques such as DIXON, dynamic contrast enhanced-MRI, and specific T2 mapping cartilage sequences allow a better understanding of the physiopathological processes that underlie these different arthropathies. They provide valuable quantitative information that aids in their differentiation and can be used as potential biomarkers of articular disease course and treatment response. | Teodoro Martín Noguerol Antonio Luna Marta Gómez Cabrera Alexie D Riofrio | 2017 | World Journal of Orthopedics2017，8，9： | 2 |
| 4 | Inhibitory effects of sulphated flavonoids isolated from Flaveria bidentis on platelet aggregation显示文摘 | Hugo A. Guglielmone Alicia M. Agnese Susana C. Nú?ez Montoya José L. Cabrera | 2004 | Thrombosis Research2004，，6： | 1 |
| 5 | Acute exercise activates nuclear factor (NF)-kappaB signaling pathway in rat skeletal muscle 显示文摘 | JI L L GOMEZ CABRERA M C STEINHAFEL N | 2004 | FASEB J2004，18，13： | 1 |
| 6 | Horizontal and vertical variability of soil properties in a trace element contaminated area显示文摘 | Pilar Burgos Engracia Madejón Alfredo Pérez-de-Mora Francisco Cabrera | 2007 | International Journal of Applied Earth Observations and Geoinformation2007，，1： | 1 |
| 7 | Film pressure distribution in water-lubricated rubber journal bearings显示文摘 | Cabrera D L Woolley N H | 2005 | Journal of Engineering Tribology2005，219，2： | 1 |
| 8 | The ICL1 gene of Pichia pastoris, transcriptional regulation and use of its promoter显示文摘 | Menendez J Valdes I Cabrera N | 2003 | Yeast2003，20，13： | 1 |
| 9 | Cumulative and residual effects of de-oiled two-phase olive mill waste application to soil on diuron sorption, leaching, degradation, and persistence显示文摘 | Antonio López-Pi?eiro Damaso Cabrera ángel Albarrán David Pe?a | 2009 | Chemosphere2009，，2： | 1 |
| 10 | The effect of treatment with omalizumab, an anti - IgE an- tibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma 显示文摘 | Bousquet J Cabrera P Berkman N | 2004 | Allergy2004，60，3： | 1 |
| 11 | Fathers and mothers at play with their 2 - and 3 - year- olds: contributions to language and cognitive development 显示文摘 | TAMIS- LEMONDA C S SHANNON J D CABRERA N J | 2004 | Child Dev2004，75，6： | 1 |
| 12 | The treat- ment of open tibial fractures and of tibial non - union with a novel external fixator 显示文摘 | Ong C T Choon D S K Cabrera N P | 2002 | Injur2002，33，9： | 1 |
| 13 | Agricultural use of three organic residues: effect on orange production and on properties of a soil of the ‘Comarca Costa de Huelva’ (SW Spain)显示文摘 | Engracia Madejón Pilar Burgos Rafael López Francisco Cabrera | 2003 | Nutrient Cycling in Agroecosystems2003，，3： | 1 |
| 14 | Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression MHC Class I Antigens In Malignant Cells显示文摘 | APTSIAURI N GARCIA-LORA A M CABRERA T | 2013 | Springer New York2013，8，6： | 1 |
| 15 | “In Situ” Amendments and Revegetation Reduce Trace Element Leaching in a Contaminated Soil显示文摘 | Alfredo Pérez-de-Mora Pilar Burgos Francisco Cabrera Engracia Madejón | 2007 | Water Air and Soil Pollution (-)2007，，1： | 1 |
| 16 | Agricultural use of three (sugar-beet) vinasse composts: effect on crops and chemical properties of a Cambisol soil in the Guadalquivir river valley (SW Spain)显示文摘 | Engracia Madejón Rafael López José M Murillo Francisco Cabrera | 2001 | Agriculture Ecosystems and Environment2001，，1： | 1 |
| 17 | Film pressure distribution in water-lubricated rubber journal bearings显示文摘 | CABRERA D L WOOLLEY N H ALLANSON D R | 2005 | IMechE2005，219，： | 1 |
| 18 | Theory of the oxidation of metals显示文摘 | Mott N F | 1949 | Rep Prog Phys1949，12，： | 1 |
| 19 | Dietary fiber and lifestyle influence serum lipids in free living adult men显示文摘 | BALLESTEROS M N CABRERA R M SAUCEDO M S | 2001 | J Am Coll Nutr2001，20，： | 1 |
| 20 | Theory of the oxidation of the metals显示文摘 | CABRERA N MOTT N F | 1948 | Rep Prog Phys1948，12，1： | 1 |
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