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| 1 | Microglia-Derived NLRP3 Activation Mediates the Pressor Effect of Prorenin in the Rostral Ventrolateral Medulla of Stress-Induced Hypertensive Rats显示文摘Increased microglial activation and neuroinflammation within autonomic brain regions such as the rostral ventrolateral medulla(RVLM)have been implicated in stress-induced hypertension(SIH).Prorenin,a member of the brain renin-angiotensin system(RAS),can directly activate microglia.The present study aimed to investigate the effects of prorenin on microglial activation in the RVLM of SIH rats.Rats were subjected to intermittent electric foot-shocks plus noise,this stress was administered for 2 h twice daily for 15 consecutive days,and mean arterial pressure(MAP)and renal sympathetic nerve activity(RSNA)were monitored.The results showed that MAP and RSNA were augmented,and this paralleled increased pro-inflammatory phenotype(M1)switching.Prorenin and its receptor(PRR)expression and the NLR family pyrin domain containing 3(NLRP3)activation were increased in RVLM of SIH rats.In addition,PLX5622(a microglial depletion agent),MCC950(a NLRP3 inhibitor),and/or PRO20(a(Pro)renin receptor antagonist)had antihypertensive effects in the rats.The NLRP3 expression in the RVLM was decreased in SIH rats treated with PLX5622.Mito-tracker staining showed translocation of NLRP3 from mitochondria to the cytoplasm in proreninstimulated microglia.Prorenin increased the ROS-triggering M1 phenotype-switching and NLRP3 activation,while MCC950 decreased the M1 polarization.In conclusion,upregulated prorenin in the RVLM may be involved in the pathogenesis of SIH,mediated by activation of the microglia-derived NLRP3 inflammasome.The link between prorenin and NLRP3 in microglia provides insights for the treatment of stress-related hypertension. | Li Hu Shutian Zhang Kokwin Ooi Xuehai Wu Jiaxiang Wu Jian Cai Yinggang Sun Jijiang Wang Danian Zhu Fuxue Chen Chunmei Xia | 2020 | Neuroscience Bulletin2020，36，5： | 3 |
| 2 | A Ten Liter Stacked Microbial Desalination Cell Packed With Mixed Ion-Exchange Resins for Secondary Effluent Desalination显示文摘 | Kuichang Zuo Jiaxiang Cai Shuai Liang | 2014 | Environmental Science and Technology2014，48，16： | 1 |
| 3 | Waveband Selection with Equivalent Prediction Performance for FTIR/ATR Spectroscopic Analysis of COD in Sugar Refinery Waste Water显示文摘The level of chemical oxygen demand(COD)is an important index to evaluate whether sewage meets the discharge requirements,so corresponding tests should be carried out before discharge.Fourier transform infrared spectroscopy(FTIR)and attenuated total reflectance(ATR)can detect COD in sewage effectively,which has advantages over conventional chemical analysis methods.And the selection of characteristic bands was one of the key links in the application of FTIR/ATR spectroscopy.In this work,based on the moving window partial least-squares(MWPLS)regression to select a characteristic wavelength,a method of equivalent wavelength selection was proposed combining with paired t-test equivalent concept.The results showed that the prediction effect of the selected wavelength was very close to that of the MWPLS method,while the number of wavelength points was much smaller.SEPAve,RP,Ave,SEPStd,and RP,Std which characterized the modeling effect were 26.3 mg L^-1,0.969,3.49 mg L^-1,and 0.006,respectively.The validation effect V-SEP and V-RP were 28.64 mg L^-1 and 0.960,respectively.The selected waveband was between 1809 cm^-1 and 1568 cm^-1.The method was of more reference value for the design of FTIR/ATR spectral instrument for COD detection. | Jun Xie Dapeng Sun Jiaxiang Cai Fuhong Cai | 2019 | Computers, Materials & Continua2019，，5： | 1 |
| 4 | Local structure-preserving al- gorithms for the 'good' Boussinesq equation 显示文摘 | Cai Jiaxiang Wang Yushun | 2013 | J Com- put Phys2013，239，1： | 1 |
| 5 | Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K显示文摘In this paper,the solubility of 4-nitroimidazole in twelve pure solvents(toluene,benzene,1,4-dioxane,acetonitrile,ethyl acetate,acetone,GBL,ethanol,methanol,n-butanol,DMF and NMP)were determined by using the laser monitoring system from 278.15 K to 323.15 K under 101.1 k Pa,which are 0.00018–0.00070,0.00021–0.00073,0.00034–0.00092,0.00038–0.00142,0.00047–0.00120,0.00126–0.00303,0.00225–0.00517,0.00310–0.00724,0.00467–0.00982,0.00453–0.01940,0.01947–0.04652,and 0.04670–0.07452,respectively.At constant temperature,the mole fraction solubility of 4-nitroimidazole were increased as the following order:toluene | Pengbao Lian Qiang Liu Lizhen Chen Cai Cao Jiaxiang Zhao Jianlong Wang | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 0 |
| 6 | Digitally tunable optical delay line based on thinfilm lithium niobate featuring high switching speed and low optical loss显示文摘A tunable optical delay line(ODL) featuring high switching speed and low optical loss is highly desirable in many fields. Here, based on the thin-film lithium niobate platform, we demonstrate a digitally tunable on-chip ODL that includes five Mach–Zehnder interferometer optical switches, four flip-chip photodetectors, and four delayline waveguides. The proposed optical switches can achieve a switching speed of 13 ns and an extinction ratio of34.9 dB. Using a modified Euler-bend-based spiral structure, the proposed delay-line waveguide can simultaneously achieve a small footprint and low optical propagation loss. The proposed ODL can provide a maximum delay time of 150 ps with a resolution of 10 ps and feature a maximum insertion loss of 3.4 dB. | WEI KE YANMEI LIN MINGBO HE MENGYUE XU JIAXIANG ZHANG ZHONGJIN LIN SIYUAN YU XINLUN CAI | 2022 | Photonics Research2022，10，11： | 0 |
| 7 | Multi-Symplectic Fourier Pseudospectral Method for the Kawahara Equation显示文摘In this paper,we derive a multi-symplectic Fourier pseudospectral scheme for the Kawahara equation with special attention to the relationship between the spectral differentiation matrix and discrete Fourier transform.The relationship is crucial for implementing the scheme efficiently.By using the relationship,we can apply the Fast Fourier transform to solve the Kawahara equation.The effectiveness of the proposed methods will be demonstrated by a number of numerical examples.The numerical results also confirm that the global energy and momentum are well preserved. | Yuezheng Gong Jiaxiang Cai Yushun Wang | 2014 | Communications in Computational Physics2014，16，6： | 0 |
| 8 | Crystallization thermodynamics of 2,4(5)-dinitroimidazole in eleven pure solvents显示文摘2,4(5)-Dinitroimidazole(2,4(5)-DNI) is an important energetic material, and it is also an important precursor for the preparation of drugs and energetic materials. In this study, the solubility of 2,4(5)-DNI in eleven pure solvents(chlorobenzene, benzene, 1,2-dichloroethane, toluene, water, isopropyl alcohol,ethyl acetate, acetonitrile, methanol, 1,4-dioxane and acetone) were measured by using a dynamic test method from 278.15 K to 323.15 K under 101.1 kPa. Four solubility models were used to fit the experimental data, which were ideal model, modified Apelblat equation, polynomial empirical equation, and λh equation. Meanwhile, the relative average deviation and root-mean-square deviation between the experimental data and the fitted data were also calculated. Furthermore, the three thermodynamic parameters,i.e., dissolution enthalpy, dissolution entropy and Gibbs energy were obtained based on solubility data.Finally, the crude product of 2,4(5)-DNI was crystallized with acetone as solvent, and the purity of the crystalline product was greater than 99.5%. | Pengbao Lian Lizhen Chen Daozhen Huang Jianxin Xu Zishuai Xu Cai Cao Jiaxiang Zhao Jianlong Wang | 2022 | Chinese Journal of Chemical Engineering2022，35，8： | 0 |
| 9 | Band Selection Method of Absorption Peak Perturbance for the FTIR/ATR SpectrumAnalysis显示文摘The rapid quantification method of human serum glucose was established by using the Fourier transform infrared spectroscopy(FTIR)and attenuated total reflection(ATR).By the subtracted spectra between glucose aqueous solution and de-ionized water,absorption peaks are calculated in fingerprint area.Based on these absorption peaks and multiple linear regression(MLR)model,discrete band selection method of absorption peaks disturbance model(APDM)was developed.5 absorption peaks 1150 cm^-1,1103 cm^-1,1078 cm^-1,1034 cm^-1,991 cm^-1 were found in fingerprint area.Used these absorption peaks to establish absorption peaks disturbance model,the optimal wavelength combinations are 1140 cm^-1,1096 cm^-1,1084 cm^-1,1030 cm^-1,993 cm^-1,the corresponding C-RMSEP and C-RP are 1.164 mmol/L and 0.828 respectively.The results show that the optimal prediction effect of APDM was obviously better than the one of the Partial least squares(PLS)model,and the complexity of the optimal model is reduced greatly also.The results also provide a theoretical basis for design of small and portable human serum glucose spectrometer. | Jun Xie Chong Wang Jiaxiang Cai Fuhong Cai | 2018 | Computers, Materials & Continua2018，，11： | 0 |
| 10 | Factorial design analytics on effects of material parameter uncertainties in multiphysics modeling of additive manufacturing显示文摘A bottleneck in Laser Powder Bed Fusion(L-PBF)metal additive manufacturing(AM)is the quality inconsistency of its products.To address this issue without costly experimentation,computational multi-physics modeling has been used,but the effectiveness is limited by parameter uncertainties and their interactions.We propose a full factorial design and variable selection approach for the analytics of main and interaction effects arising from material parameter uncertainties in multi-physics models.Data is collected from high-fidelity thermal-fluid simulations based on a 2-level full factorial design for 5 selected material parameters.Crucial physical phenomena of the L-PBF process are analyzed to extract physics-based domain knowledge,which are used to establish a validation checkpoint for our study.Initial data visualization with half-normal probability plots,interaction plots and standard deviation plots,is used to assess if the checkpoint is being met.We then apply the combination of best subset selection and the LASSO method on multiple linear regression models for comprehensive variable selection.Analytics yield statistically and phyiscally validated findings with practical implications,emphasizing the importance of parameter interactions under uncertainty,and their relation to the underlying physics of L-PBF. | Amanda Giam Fan Chen Jiaxiang Cai Wentao Yan | 2023 | npj Computational Materials2023，，1： | 0 |
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