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| 1 | Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy显示文摘Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood–brain barrier(BBB) and insufficient drug accumulation in the tumor region. Although many approaches, including various nanosystems, have been developed to promote the distribution of chemotherapeutics in the brain tumor, the delivery efficiency and the possible damage to the normal brain function still greatly restrict the clinical application of the nanocarriers.Therefore, it is urgent and necessary to discover more safe and effective BBB penetration and gliomatargeting strategies. In the present study, menthol, one of the strongest BBB penetration enhancers screened from traditional Chinese medicine, was conjugated to casein, a natural food protein with brain targeting capability. Then the conjugate self-assembled into the nanoparticles to load anti-cancer drugs.The nanoparticles were characterized to have appropriate size, spheroid shape and high loading drug capacity. Tumor spheroid penetration experiments demonstrated that penetration ability of mentholmodified casein nanoparticles(M-CA-NP) into the tumor were much deeper than that of unmodified nanoparticles. In vivo imaging further verified that M-CA-NPs exhibited higher brain tumor distribution than unmodified nanoparticles. The median survival time of glioma-bearing mice treated with HCPT-MCA-NPs was significantly prolonged than those treated with free HCPT or HCPT-CA-NPs. HE staining ofthe organs indicated the safety of the nanoparticles. Therefore, the study combined the advantages of traditional Chinese medicine strategy with modern delivery technology for brain targeting, and provide a safe and effective approach for glioma therapy. | Caifang Gao Jianming Liang Ying Zhu Chengli Ling Zhekang Cheng Ruixiang Li Jing Qin Weigen Lu Jianxin Wang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 12 |
| 2 | Stratum energy of coal-bed gas reservoir and their control on the coal-bed gas reservoir formation显示文摘Stratum energy of coal-bed gas reservoir, including coal-radix flexibility energy, groundwater flexibility energy and gas flexibility energy (hereinafter 'three energy'), depends on the energy homeostasis system, the core process of which is the effective transfer of energy and the geological selective process. Combining with the mechanics experimentations of coal samples, different flexibility energy has been analyzed and researched quantificationally, and a profound discussion to their controls on the coal-bed gas reservoir formation has been made. It is shown that when gas reservoir is surrounded by edge water and bottom water, the deposited energy in the early phase of forming gas reservoir is mostly coal-radix and gas flexibility energy, but the effect of groundwater flexibility energy increases while water-body increases. The deposited energy in the middle and later phase of forming gas reser voir is mostly gas flexibility energy, which is greater than 80% of all deposited energy. In the whole process, larger groundwater body exerts greater influences on gas accumulation. The paper indicated that higher stratum energy is more propitious to forming coal-bed gas reservoir. And higher coal-radix flexibility energy and gas flexibility energy are more propitious to higher yield of gas reservoirs, while higher groundwater flexibility energy is more propitious to stable yield of gas reservoirs. Therefore, the key to evaluating the coal-bed gas reservoir formation is the stratum energy of coal-bed gas reservoir. | WU CaiFang QIN Yong FU XueHai | 2007 | Science China Earth Sciences2007，50，9： | 9 |
| 3 | Self-adjusted elastic action and its CBM pool-forming effect of the high rank coal reservoir显示文摘The coal reservoir is a kind of geologic body with considerable elasticity, and its response to stress is more sensitive than the routine ones. In the pool-forming process of the coalbed methane, (CBM) the action of many external geodynamic factors in the coal reservoir is represented by the ability of CBM’s diffusion and migration in the coal reservoir. Therefore, the occurrence of the natural fissures in the coal reservoir becomes a key that determines whether the CBM pool can be formed or not. Based on the principle, the authors have designed a comprehensive method of physical modeling to study the elasticity of the coal matrix block with different coal ranks in the light of the solid to fluid coupling, have established the model of the volume deformation (self-adjusted elastic effect) of the coal reservoir under the condition of the effective stress-adsorption/desorption, and have obtained a correct understanding of the law of the elastic deformation. Afterwards, a new viewpoint, named as the self-closing elastic effect for forming the CBM pool in the high rank reservoir, is put forward, providing an initial point and a scientific basis for a further investigation into its dynamic factors, possible mechanism and role in the CBM energy-balancing system. | QIN Yong FU Xuehai WU Caifang FU Guoyou BU Yingying | 2005 | Chinese Science Bulletin2005，50，S1： | 9 |
| 4 | 胃食管反流病:内镜评估与治疗方面的革新显示文摘内镜技术的创新为胃食管反流病(GERD)的诊治带来了巨大进步。作为世界上最常见的胃肠疾病之一,GERD一直是内镜介入治疗的前沿。目前,GERD的初步诊断是基于症状和质子泵抑制剂(PPI)初期治疗有效,但这对治疗策略的指导价值有限。然而,内镜检查和病理活检可直接观察和判断食管的异常结构和病理生理损伤;同时,内镜治疗的出现给PPI治疗依从性较差或治疗反应不佳以及不适合行胃底折叠抗反流手术的患者提供了新的治疗选择。本综述对内镜检查和活检在经过恰当的抗反流药物治疗后持续存在GERD相关临床表现的患者中的应用情况进行了概述,并介绍了目前内镜治疗GERD的各项新技术及其优缺点。今后的研究需要对GERD患者进行分层研究,并力图阐明该疾病的主要病理生理机制。 | Sheng Chen Feng Du Changqing Zhong Caifang Liu Xiaoying Wang Yan Chen Gang Wang Xiaopei Gao Lu Zhang Lianyong Li Wei Wu | 2021 | Gastroenterology Report2021，9，5： | 4 |
| 5 | Single Nucleotide Polymorphism of FSHβ Gene Associated with Reproductive Traits in Japanese Flounder (Paralichthys olivaceus)显示文摘Follicle stimulating hormone β (FSHβ) of Japanese flounder (Paralichthys olivaceus) plays a key role in the regulation of gonadal development.This study aimed to investigate molecular genetic characteristics of the FSHβ gene and elucidate the effects of single nucleotide polymorphisms (SNPs) of FSHβ on reproductive traits in Japanese flounder.We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the FSHβ gene in 60 individuals.We identified only an SNP (T/C) in the coding region of exon3 of FSHβ.The SNP (T/C) did not lead to amino acid changes at the position 340 bp of FSHβ gene.Statistical analysis showed that the SNP was significantly associated with testosterone (T) level and gonadosomatic index (GSI) (P<0.05).Individuals with genotype TC of the SNP had significantly higher serum T levels and GSI (P<0.05) than that of genotype CC.Therefore, FSHβ gene could be a useful molecular marker in selection for prominent reproductive trait in Japanese Flounder. | HE Feng WEN Haishen YU Dahui LI Jifang SHI Bao CHEN Caifang ZHANG Jiaren JIN Guoxiong CHEN Xiaoyan Shi Dan Yang Yanping | 2010 | Journal of Ocean University of China2010，9，4： | 4 |
| 6 | Surface modification of PGP for a neutrophil–nanoparticle co-vehicle to enhance the anti-depressant effect of baicalein显示文摘Exploiting cells as vehicles combined with nanoparticles combined with therapy has attracted increasing attention in the world recently. Red blood cells, leukocytes and stem cells have been used for tumor immunotherapy, tissue regeneration and inflammatory disorders, and it is known that neutrophils can accumulate in brain lesions in many brain diseases including depression. N-Acetyl Pro–Gly–Pro(PGP) peptide shows high specific binding affinity to neutrophils through the CXCR2 receptor. In this study, PGP was used to modify baicalein-loaded solid lipid nanoparticles(PGP-SLNs) to facilitate binding to neutrophils in vivo. Brain-targeted delivery to the basolateral amygdala(BLA) was demonstrated by enhanced concentration of baicalein in the BLA. An enhanced anti-depressant effect was observed in vitro and in vivo. The mechanism involved inhibition of apoptosis and a decrease in lactate dehydrogenase release. Behavioral evaluation carried out with rats demonstrated that anti-depression outcomes were achieved. The results indicate that PGP-SLNs decrease immobility time, increase swimming time and climbing time and attenuate locomotion in olfactory-bulbectomized(OB) rats. In conclusion, PGP modification is a strategy for targeting the brain with a cell–nanoparticle delivery system for depression therapy. | Baoyu Chen Man Luo Jianming Liang Chun Zhang Caifang Gao Jue Wang Jianxin Wang Yongji Li Desheng Xu Lina Liu Ning Zhang Huijun Chen Jing Qin | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 4 |
| 7 | Kyphoplasty versus vertebroplasty for the treatment of malignant vertebral compression fractures caused by metastases: a retrospective study显示文摘 | Li Zhi Ni Caifang Chen Long Sun Zhiyong Yang Chao Zhao Xin Wang Yanwei | 2014 | Chinese Medical Journal2014，，8： | 4 |
| 8 | Chiral Frustrated Lewis Pairs Catalyzed Highly Enantioselective Hydrosilylations of Ketones显示文摘A highly enantioselective Piers-type hydrosilylation of simple ketones was successfully realized using a chiral frustrated Lewis pair of tri-tert-butylphosphine and chiral diene-derived borane as catalyst.A wide range of optically active secondary alcohols were furnished in 80%-99% yields with 81%-97% ee's under mild reaction conditions. | Xiaoqin Liu Qiaotian Wang Caifang Han Xiangqing Feng Haifeng Du | 2019 | Chinese Journal of Chemistry2019，37，7： | 3 |
| 9 | Interlayer interference mechanism of multi-seam drainage in a CBM well:An example from Zhucang syncline显示文摘Based on the characteristics of the strong volatility of physical property in vertical direction, high gas content, high resource abundance and large exploitation potentiality of coal reservoir in Bide-Santang basin of Zhina coal field, we study the generation mechanism of interlayer interference, propagation rules of reservoir pressure drop and influencing factors of gas productivity in CBM multi-seam drainage in the paper. On the basis of the actual production data of X-2 well of Zhucang syncline in Bide-Santang basin,by simulating the gas production process of a CBM well under the condition of multiple seam with COMET3 numerical simulation software, we analyze the influencing factors of gas productivity during the process of multi-seam drainage, and illuminate the interlayer interference mechanism of multiseam drainage. The results show that permeability, reservoir pressure gradient, critical desorption pressure and fluid supply capacity of stratum have great influence on gas productivity of multi-seam drainage while coal thickness has little influence on it. Permeability, reservoir pressure gradient and fluid supply capacity of stratum affect the propagation velocity of reservoir pressure drop and thereby affect the final gas productivity. Moreover, the influence of critical desorption pressure on gas productivity of multiseam drainage is reflected in the gas breakthrough time and effective desorption area. | Jiang Wei Wu Caifang Wang Qiao Xiao Zhenghui Liu Yang | 2016 | International Journal of Mining Science and Technology2016，26，6： | 3 |
| 10 | Uterine artery embolization in association with methotrexate infusion for the treatment of tubal ectopic pregnancy显示文摘Objective To investigate the safety, feasibility, and effectiveness of uterine artery embolization in association with methotrexate(MTX) infusion for the treatment of tubal ectopic pregnancy. Methods Fifty-one patients with tubal ectopic pregnancy were referred for interventional management. All patients received super-selective arteriography of the uterine artery, were infused with 50–100 mg methotrexate(MTX) through a catheter, and underwent embolization of the uterine artery with a gel-foam pledge. Clinical presentation, findings of physical examination, β-HCG values, and the size of the ectopic mass were documented for comparison. The concentration of MTX in blood was evaluated at 0.5, 6, 12, 24, 36, and 48 hours after the procedure. Results Forty-seven out of the 51 patients had clinical resolution of their tubal pregnancy(92.2%). The average time for the β-HCG value to decrease and come back to normal was 9.16 ± 2.54 days(mean +/-SD). MTX levels in peripheral blood could not be detected for patients who received 50 or 75 mg MTX at 36 hours after the procedure, while the MTX level was 0.01 μmol/L at 48 hours after the procedure for patients who received 100 mg. Out of the 4 cases whose ectopic mass size was ≥5 cm, 3 failed to respond to the treatment; however, those whose ectopic mass size was ≤5 cm responded positively to the treatment, regardless of the β-HCG concentration and abdominal bleeding, except for 1 patient who had to undergo laparoscopy for severe abdominal pain and who showed a reduction in her β-HCG level. Conclusion Uterine artery embolization in association with methotrexate infusion is safe and effective in the treatment of tubal ectopic pregnancy, especially for those women with mild to moderate bleeding, or for those at risk of a major hemorrhage. The selection criterion of mass size >5 cm should, therefore, be carefully considered. | Zhi Li Wenjian Xu Bo Hu Mingming Li Jianwei Zhou Caifang Ni | 2018 | Journal of Interventional Medicine2018，1，3： | 2 |
| 11 | A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis显示文摘With the development of synthesis technology, modified messenger RNA(mRNA) has emerged as a novel category of therapeutic agents for a broad of diseases. However, effective intracellular delivery of mRNA remains challenging, especially for its sensitivity to enzymatic degradation. Here, we propose a polyphenol-assisted handy delivery strategy for efficient in vivo delivery of IL-10 mRNA.IL-10 mRNA binds to polyphenol ellagic acid through supramolecular binding to yield a negatively charged core, followed by complexing with linear polyetherimide and coating with bilirubin-modified hyaluronic acid to obtain a layer-by-layer nanostructure. The nanostructure specifically up-regulated the level of IL-10, effectively inhibited the expression of inflammatory factors, promoted mucosal repair, protected colonic epithelial cells against apoptosis, and exerted potent therapeutic efficacy in dextran sulfate sodium salt-induced acute and chronic murine models of colitis. The designed delivery system without systemic toxicity has the potential to facilitate the development of a promising platform for mRNA delivery in ulcerative colitis treatment. | Zhejie Chen Wei Hao Caifang Gao Yangyang Zhou Chen Zhang Jinming Zhang Ruibing Wang Yitao Wang Shengpeng Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 2 |
| 12 | Biodegradable magnesium alloy with eddy thermal effect for effective and accurate magnetic hyperthermia ablation of tumors显示文摘Magnetic hyperthermia therapy(MHT)is able to ablate tumors using an alternating magnetic field(AMF)to heat up magnetocaloric agents(e.g.magnetic nanoparticles)administered into the tumors.For clinical applications,there is still a demand to find new magnetocaloric agents with strong AMF-induced heating performance and excellent biocompatibility.As a kind of biocompatible and biodegradable material,magnesium(Mg)and its alloys have been extensively used in the clinic as an implant metal.Herein,we discovered that the eddy thermal effect of the magnesium alloy(MgA)could be employed for MHT to effectively ablate tumors.Under low-field-intensity AMFs,Mg A rods could be rapidly heated,resulting in a temperature increase in nearby tissues.Such AMF-induced eddy thermal heating of MgA could not only be used to kill tumor cells in vitro,but also be employed for effective and accurate ablation of tumors in vivo.In addition to killing tumors in mice,we further demonstrated that VX2 tumors of much larger sizes growing in rabbits after implantation of Mg A rods could also be eliminated after exposure to an AMF,illustrating the ability of MgA-based MHT to kill large-sized tumors.Moreover,the implanted MgA rods showed excellent biocompatibility and~20%of their mass was degraded within three months.Our work thus discovered for the first time that non-magnetic biodegradable Mg A,an extensively used implant metal in clinic,could be used for effective magnetic thermal ablation of tumors under a low-field-intensity AMF.Such a strategy could be readily translated into clinical use. | Nailin Yang Fei Gong Liang Cheng Huali Lei Wei Li Zongbin Sun Caifang Ni Zhanhui Wang Zhuang Liu | 2021 | National Science Review2021，8，1： | 1 |
| 13 | Effective migration system of coalbed methane reservoirs in the southern Qinshui Basin显示文摘Effective migration system of coalbed methane(CBM)reservoir,which was controlled by development degree and opening-closing degree of fractures,determines the permeability of coal reservoir and can be characterized by the pore-fracture system in the extrinsic form.In this paper,based on coal matrix elastic self-regulating effect theory and coal reservoir combined elastic energy theory,the fracture opening-closing degree parameterΔand the fracture development degree parameterξare suggested for the quantitative study of the effective migration system of CBM reservoir in southern Qinshui Basin.Further,the control functions ofξandΔto CBM enrichment and high production are discussed.The results show that in present stage the area with highξvalue is located in Anze and Qinyuan,and then Zhengzhuang and Fangzhuang,where fracture development degree is high.The area with highΔvalue is located in Zhengzhuang and Fanzhuang,and then Anze and Qinyuan,indicating where coal matrix elastic self-regulating positive effect dominates and fractures tend to be open.Through the comprehensive analysis onξandΔ,it can be found that their best match area is located in Zhengzhuang and Fanzhuang,with high values for fracture development degree and opening-closing degree probably bringing about high fluid pressure and good permeability of reservoirs,which are advantageous to an abundant CBM production. | WU CaiFang QIN Yong ZHOU LongGang | 2014 | Science China Earth Sciences2014，57，12： | 1 |
| 14 | Application of auto-adapting neural networks in forecasting gas content with geological factors显示文摘 | Wu Caifang Zeng Yong Zhang Zixu | 2003 | Journal of Liaoning Technical University:Natural Science2003，22，5： | 1 |
| 15 | Optimal design and control of a novel press with an extra motor显示文摘 | Meng Caifang Zhang Ce | 2004 | Mechanism and Machine Theory2004，39，： | 1 |
| 16 | Application of The Third Theory of Quantification in Coal and Gas Outburst Forecast 显示文摘 | WU Caifang QIN Yong ZHANG Xuliang | 2004 | Journal of Coal Science and Engineering2004，10，2： | 1 |
| 17 | NMR studies of stock process water and reaction pathways in hydrothermal carbonization of furfural residue显示文摘Hydrothermal carbonization(HTC) is a valuable approach to convert furfural residue(FR) into carbon material. The prepared biochars are usually characterized comprehensively, while the stock process water still remains to be studied in detail. Herein, a NMR study of the main components in stock process water generated at different HTC reaction conditions was reported. Various qualitative and quantitative NMR techniques(~1H and ^(13)C NMR,~1H-~1H COSY and ~1H-^(13)C HSQC etc.) especially 1D selective gradient total correlation spectroscopy(TOCSY NMR) were strategically applied in the analysis of HTC stock process water. Without separation and purification, it was demonstrated that the main detectable compounds are 5-hydroxymethylfurfural, formic acid, methanol, acetic acid, levulinic acid, glycerol, hydroxyacetone and acetaldehyde in this complicate mixture. Furthermore, the relationship between the concentration of major products and the reaction conditions(180-240 ℃ at 8 h, and 1-24 h at 240 ℃) was established. Finally, reasonable reaction pathways for hydrothermal conversion of FR were proposed based on this result and our previously obtained characteristics of biochars. The routine and challenging NMR methods utilized here would be an alternative other than HPLC or GC for biomass conversion research and can be extended to more studies. | Fen Yue Christian Marcus Pedersen Xiuyin Yan Yequn Liu Danlei Xiang Caifang Ning Yingxiong Wang Yan Qiao | 2018 | Green Energy & Environment2018，3，2： | 1 |
| 18 | Relationship between vitamin D receptor gene polymorphism and periodontitis 显示文摘 | Sun Jinglin Meng Huanxin Cao Caifang | 2002 | J Periodont Res2002，37，4： | 1 |
| 19 | Involutegearing with small tooth number显示文摘 | Pan Fengzhang Jing Xiubing Meng Caifang | 2004 | Chinese MechanicalEngineering Society : English Edition2004，，： | 1 |
| 20 | LOCAL CONVERGENCE OF AN EM-LIKE IMAGE RECONSTRUCTION METHOD FOR DIFFUSE OPTICAL TOMOGRAPHY显示文摘在这份报纸,反复的公式明确地为稳定的外部来源开发了的像他们的图象重建向一次固定的点重复作为一张地图被重写。图象重建方法的本地集中然后被证明。最后,一个三维的数字图象重建例子被举。[从作者抽象] | Caifang Wang Tie Zhou | 2011 | Journal of Computational Mathematics2011，29，1： | 1 |
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