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| 1 | Surveying of the deformed terraces and crust shortening rate in the northwestern Tarim Basin显示文摘Relief surveying and chronology study were carried out on the deformed river terraces across the Artushi anticline belt in the northwestern Tarim Basin. The crust shortening rate of this anticline belt since late Pleistocene was calculated to be up to 5-6 mm/a. The total crust shortening rate from the northwestern Tarim Basin to southwestern Tianshan since late Pleistocene was estimated to be over 10 mm/a. | SHEN Jun WANG Yipeng ZHAO Ruibing LI Jun D.Burbank K.Share | 2001 | Chinese Science Bulletin2001，46，12： | 13 |
| 2 | SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts显示文摘The ongoing outbreak of Coronavirus Disease 2019(COVID-19)has become a global public health emergency.SARScoronavirus-2(SARS-CoV-2),the causative pathogen of COVID-19,is a positive-sense single-stranded RNA virus belonging to the family Coronaviridae.For RNA viruses,virus-encoded RNA helicases have long been recognized to play pivotal roles during viral life cycles by facilitating the correct folding and replication of viral RNAs.Here,our studies show that SARS-CoV-2-encoded nonstructural protein 13(nsp13)possesses the nucleoside triphosphate hydrolase(NTPase)and RNA helicase activities that can hydrolyze all types of NTPs and unwind RNA helices dependently of the presence of NTP,and further characterize the biochemical characteristics of these two enzymatic activities associated with SARS-CoV-2 nsp13.Moreover,we found that some bismuth salts could effectively inhibit both the NTPase and RNA helicase activities of SARS-CoV-2 nsp13 in a dose-dependent manner.Thus,our findings demonstrate the NTPase and helicase activities of SARS-CoV-2 nsp13,which may play an important role in SARS-CoV-2 replication and serve as a target for antivirals. | Ting Shu Muhan Huang Di Wu Yujie Ren Xueyi Zhang Yang Han Jingfang Mu Ruibing Wang Yang Qiu Ding-Yu Zhang Xi Zhou | 2020 | Virologica Sinica2020，35，3： | 11 |
| 3 | Efficient Extraction of Lithium Ions from High Mg/Li Ratio Brine through the Synergy of TBP and Hydroxyl Functional Ionic Liquids显示文摘of main observation and conclusion The extraction of Li^+from the high Mg/Li ratio brine was performed using hydroxyl functional ionic lic-uids(ILs)as the coextractant and tributyl phosphate(TBP)as the extractant.irsty the extractive system,1-2-hydroxyethyl-3-mnethylimidazolumbis(trifuoromethylsulfonyl)imide([HOEmim][NTf2])+TBP was proved to exhibit the highest extraction efficiency of Li^+(88.15%)from LiCl aqueous solutions among the extractants composed of differents TB P,and ls+TBP.Effects of various extraction parameters on the extraction eficiencies of Li^+and Mg^2+were then investigated.95.01%of Li^+was extracted and the Li^+/Mg^2+separation factor reached 405.76 in a singl-stage at 278.15 Kand O/A of 2:1.The extraction complexes were determined by the slope analysis method and ESI-MS analysis,and the metal complexes in the organic phase were indcated to be mainly[L-2TBP][NTf;J.The striping study showed that 92.86%of i*was stripped with 1.0 mol·L^-1 HCl.98%extraction capacity of the synergyextractants was remained after 5 regeneration cycles.The thermodynamic parameters(△G°,△H°,and△S°),together with the mechanism of the Li^+extraction were further demonstrated finally,According to the results,[HOEmim][NTf2]+TBP extraction system showed promising performance in extracting lithium from salt lake brine with high Mg/Li ratio. | Ruibing Bai Junfeng Wang Li Cui Shicheng Yang Wei Qian Penglei Cui Yanqiang Zhang | 2020 | Chinese Journal of Chemistry2020，38，12： | 4 |
| 4 | Metabolic risk factors associated with sudden cardiac death(SCD)during acute myocardial ischemia显示文摘Sudden cardiac death(SCD)is the leading cause of death worldwide.Myocardial ischemia(MI)is the most common underlying causal disorder for SCD.Metabolic risks leading to SCD during acute MI are still not fully understood.Here,using tissue metabolomics,we aimed to investigate myocardial metabolic alterations relevant to SCD events in an acute MI rat model induced by coronary artery ligation(CAL).Thirty-four rats were successfully performed CAL,of which 13 developed lethal ventricular tachyarrhythmia(LVTA)-SCD and 7 developed severe atrioventricular block(AB)-SCD.Fourteen rats that survived within 70 min after the ligation were served as peer controls.The partial least squares-discriminant analysis plots demonstrated clear separations between the SCD rats and controls,indicating obvious differences in myocardial metabolome between these rats.The levels of isoleucine,lactate,glutamate choline,phosphorylcholine,taurine and asparagine in ischemic myocardia were positively associated with LVTA-SCD events;in contrast,the levels of alanine,urea,phenylalanine,linoleic acid,elaidic acid and stearic acid were inversely correlated with LVTA-SCD events.The levels of glutamate and urea were positively and negatively relevant to AB-SCD events,respectively.The dangerous metabolites indicated that lower levels of energy substrates,severe hypoxia,the inhibition of transamination and hyper sympathetic excitement and reactive oxygen species in myocardia were vulnerable to SCD during acute MI.The results suggest fatal metabolic alterations correlated with SCD events during acute MI,which could offer novel clues for the prevention or treatment of acute MI-related SCD. | Dian Wang Xingxing Wang Jiayan Wu Ruibing Su Jing Kong Xiaojun Yu | 2017 | Forensic Sciences Research2017，2，3： | 2 |
| 5 | pH-Responsive supramolecular DOX-dimer based on cucurbit[8]uril for selective drug release显示文摘A supramolecular dimer of doxorubicin(DOX)was constructed via ternary host-guest interactions between cucurbit[8]uril(CB[8])and tryptophan modified DOX(DOX-Trp,connected with an acid-labile bond)and we demonstrate for the first time that a supramolecular dimer of DOX can be formed upon homo-dimerization by CB[8],which may act as a stimuli pH-responsive,supramolecular DOX dimer prodrug system.This supramolecular DOX dimer transported DOX efficiently and selectively to cancer cells,thereby exhibiting significantly minimized cytotoxicity against noncancerous cells while maintaining effective cytotoxicity against cancer cells.Under this strategy,many other anticancer drugs could be chemically modified and loaded as a dimeric'ammunition'into CB[8]as supramolecular dimer prodrug systems(or a'jet fighter')for improved cancer therapy. | Qian Cheng Shengke Li Yanlong Ma Hang Yin Ruibing Wang | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 6 | A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis显示文摘With the development of synthesis technology, modified messenger RNA(mRNA) has emerged as a novel category of therapeutic agents for a broad of diseases. However, effective intracellular delivery of mRNA remains challenging, especially for its sensitivity to enzymatic degradation. Here, we propose a polyphenol-assisted handy delivery strategy for efficient in vivo delivery of IL-10 mRNA.IL-10 mRNA binds to polyphenol ellagic acid through supramolecular binding to yield a negatively charged core, followed by complexing with linear polyetherimide and coating with bilirubin-modified hyaluronic acid to obtain a layer-by-layer nanostructure. The nanostructure specifically up-regulated the level of IL-10, effectively inhibited the expression of inflammatory factors, promoted mucosal repair, protected colonic epithelial cells against apoptosis, and exerted potent therapeutic efficacy in dextran sulfate sodium salt-induced acute and chronic murine models of colitis. The designed delivery system without systemic toxicity has the potential to facilitate the development of a promising platform for mRNA delivery in ulcerative colitis treatment. | Zhejie Chen Wei Hao Caifang Gao Yangyang Zhou Chen Zhang Jinming Zhang Ruibing Wang Yitao Wang Shengpeng Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 2 |
| 7 | Survivin反义寡核苷酸对宣威肺腺癌细胞凋亡的影响(英文)显示文摘Objective:The aim of the study was to investigate the effects of Survivin antioligonucleotide on the proliferation,apoptosis and cell cycle of Xuanwei lung adenocarcinoma cell XWLC-05.Methods:Specific targeting Survivin ASODN was composed firstly.XWLC-05 would be divided into 4 groups:Group Sham(blank),Group Lip(simple liposome),Group Lip-SODN(transfected sense oligonucleotide) and Group Lip-ASODN(transfected ASODN).All groups had been transfected under the same condition for 48 hours.Then West blotting was used to check the expression of Survivin in cells from different groups and flow cytometer was used to find out the apoptosis rate of cells in different groups.Results:The expression of XWLC-05 Survivin in Group Lip-ASODN decreased obviously and apoptosis rate was significantly higher than that of other groups(P < 0.05).Conclusion:XWLC-05 transfected by Survivin ASODN could down regulate the expression of Survivin and lower expression of Survivin might lead to the apoptosis of XWLC-05 and restrain the proliferation of cancer cells. | Weiwei Wang Gaofeng Li Zhipeng Hong Ruibing Cheng Jipeng Zhang Lianhua Ye | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，5： | 1 |
| 8 | Multi-dimensional and complicated electromagnetic interference hardware-in-the-loop simulation method显示文摘A typical electronic communication system, such as GPS receiver, unmanned aerial vehicle's(UAV's) data link, and radar, faces multi-dimensional and complicated electromagnetic interference in operating environment. To measure the antiinterference performance of the electronic communication system in the complicated electromagnetic interference environment, a method of multi-dimensional and complicated electromagnetic interference hardware-in-the-loop simulation in an anechoic room is proposed. It takes into account the characteristics of interference signals and the positional relationship among interference, the receiver and the transmitter of the electronic communication system.It uses the grey relational method and the angular domain mapping error correction method to control the relevant parameters,the microwave switch and so on, thus achieving the approximately actual mapping of the outdoor multi-dimensional and complicated electromagnetic interference in the anechoic room. To verify the effectiveness of this method, the multi-dimensional and complicated electromagnetic interference of the UAV's data link is simulated as an example. The results show that the degree of correlation between the calculated signal to interference ratio of the data link receiver in the actual scene and the measured signal to interference ratio of the data link receiver simulated with this method in the anechoic room is 0.968 1, proving that the method is effective for simulating the complicated electromagnetic interference. | Shuxia Guo Yafeng Wang Ruibing Liu Ying Gao | 2015 | Journal of Systems Engineering and Electronics2015，26，6： | 1 |
| 9 | Fault detection in Rule-based Software systems显示文摘 | Dong Wang Ruibing Hao David Lee | 2003 | Information and Software Technology2003，，12： | 1 |
| 10 | Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma显示文摘Despite extensive use of radiotherapy in nasopharyngeal carcinoma(NPC)treatment because of its high radiosensitivity,there have been huge challenges in further improving therapeutic effect,meanwhile obviously reducing radiation damage.To this end,synergistic chemoradiotherapy has emerged as a potential strategy for highly effective NPC therapy.Here,we developed RGD-targeted platinum-based nanoparticles(RGD-PtNPs,denoted as RPNs)to achieve targeted chemoradiotherapy for NPC.Such nanoparticles consist of an RGD-conjugated shell and a cis-platinum(CDDP)crosslinking core.Taking advantage of RGD,the RPNs may effectively accumulate in tumor,penetrate into tumor tissues and be taken by cancer cells,giving rise to a high delivery efficiency of CDDP.When they are fully enriched in tumor sites,the CDDP loaded RPNs can act as radiotherapy sensitizer and chemotherapy agents.By means of X-ray-promoted tumor cell uptake of nanoparticle and CDDP-induced cell cycle arrest in radiation-sensitive G2/M phases,RPNs may offer remarkable therapeutic outcome in the synergistic chemoradiotherapy for NPC. | Yuxun Ding Xiaohui Xiao Lingli Zeng Qiuping Shang Wei Jiang Sha Xiong Xiaohui Duan Jun Shen Ruibing Wang Jinshan Guo Yue Pan | 2021 | Bioactive Materials2021，6，12： | 1 |
| 11 | Determination of phenylurea and triazine herbicides in milk by microwave assisted ionic liquid microextraction high-performance liquid chromatography显示文摘 | Shiqian Gao Jingyan You Xia Zheng Ying Wang Ruibing Ren Rui Zhang Yuping Bai Hanqi Zhang | 2010 | Talanta2010，，4： | 1 |
| 12 | Simultaneous determination of eight bioactive bakkenolides of Petasites tatewakianus Kitam by HPLC–UV显示文摘A high-performance liquid chromatography coupled with variable wavelength detection(HPLC–UV)was developed to evaluate the quality of Petasites tatewakianus Kitam through a simultaneous determination of eight bakkenolides:bakkenolide-L,bakkenolide-D,bakkenolide-B,bakkenolide-Ⅰa,bakkenolide-Ⅶa,bakkenolide-Ⅳa,bakkenolide-Ⅲa and homofukinolide.With a C18 analytical column,the eight analytes were efficiently separated using tetrahydrofuran–acetonitrile–water as the mobile phase in a constant program.The limits of detection and limits of quantitation of the method ranged 0.42–2.56μg/mL and 1.22–8.40μg/mL,respectively.The intra-and inter-day precisions of the method were all less than 1.83%.All the recoveries for the spiked analytes ranged 97.8%–102.4%.There were statistically significant differences among the contents of the eight bakkenolides in different parts and origins of P.tatewakianus(Po0.01).The content of total bakkenolides in rhizome was higher than that in other parts of the plant.The content of total bakkenolides in rhizome from Baishan was higher than those in other localities.The result suggested that rhizome may be the most valuable part of P.tatewakianus,and P.tatewakianus from Baishan may be the best plant resource.Our results might serve as a sound foundation for further study and application of this plant. | Jianming He Qin Wang Yan Wang Ruibing Chen Yuyang Zhang Meili Guo | 2013 | Acta Pharmaceutica Sinica B2013，3，5： | 1 |
| 13 | Determination of the active constituents in Arnebia euchroma (Royle) Johnst. by ionic liquid-based ultrasonic-assisted extraction high-performance liquid chromatography显示文摘 | Yao Xiao Ying Wang Shiqian Gao Rui Zhang Ruibing Ren Na Li Hanqi Zhang | 2011 | Journal of Chromatography B2011，，20： | 1 |
| 14 | Fault Detection in Rule-based Software Systems显示文摘 | Wang Dong Hao Ruibing Lee D | 2003 | Information and Software Technology2003，45，12： | 1 |
| 15 | Reviving chloroquine for anti-SARS-CoV-2 treatment with cucurbit[7]uril-based supramolecular formulation显示文摘The wide-spreading SARS-CoV-2 virus has put the world into boiling water for more than a year,however pharmacological therapies to act effectively against coronavirus disease 2019(COVID-19)remain elusive.Chloroquine(CQ),an antimalarial drug,was found to exhibit promising antiviral activity in vitro and in vivo at a high dosage,thus CQ was approved by the FDA for the emergency use authorization(EUA)in the fight against COVID-19 in the US,but later was revoked the EUA status due to the severe clinical toxicity.Herein,we show that supramolecular formulation of CQ by a macrocyclic host,curcurbit[7]uril(CB[7]),reduced its non-specific toxicity and improved its antiviral activity against coronavirus,working in synergy with CB[7].CB[7]was found to form 1:1 host-guest complexes with CQ,with a binding constant of$104 L/mol.The CQ-CB[7]formulation decreased the cytotoxicity of CQ against Vero E6 and L-02 cell lines.In particular,the cytotoxicity of CQ(60 mmol/L)against both Vero E6 cell line and L-02 cell lines was completely inhibited in the presence of 300 mmol/L and 600 mmol/L CB[7],respectively.Furthermore,the CB[7]alone showed astonishing antiviral activity in SARS-CoV-2 infected Vero E6 cells and mouse hepatitis virus strain A59(MHV-A59)infected N2 A cells,and synergistically improved the antiviral activity of CQ-CB[7],suggesting that CB[7]-based CQ formulation has a great potential as a safe and effective antiviral agent against SARS-CoV-2 and other coronavirus. | Cheryl H.T.Kwong Jingfang Mu Shengke Li Yaohui Fang Qianyun Liu Xiangjun Zhang Hiotong Kam Simon M.Y.Lee Yu Chen Fei Deng Xi Zhou Ruibing Wang | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 16 | A covalently attached film based on poly (methacrylic acid)-capped Fe3O4nanoparticles显示文摘 | Zhang Hao Wang Ruibing Zhang Gang | 2003 | Thin Solid Films2003，429，： | 1 |
| 17 | Analysis of secondary flow in shell-side channel of trisection helix heat exchangers显示文摘 | Wang Weihan Chen Yaping Coo Ruibing | | 0，，： | 1 |
| 18 | Survivin-ASODN靶向治疗XWLC-50细胞移植瘤裸鼠的实验研究(英文)显示文摘Objective:The aim of this study was to study the inhibiting effect of survivin mRNA on transplanted XWLC-05 tumor on nude mice.Methods:We established XWLC-05 transplanted nude mice model.44 mice would be divided randomly into 4 groups:control group (blank),Lip group (simple liposome),survivin SODN group (transfected by sense oligonucleotide) and survivin ASODN group (transfected by antisense oligonucleotide).We would study general activities of nude mice in these 4 groups,measure the size of tumor and calculate the tumor inhabiting rate also.Pathological methods were applied in the analysis of the effect of different treatment on heart,kidney and liver of nude mice in these 4 groups.Results:Tumor grew slowly and size,weight of tumor was lower in survivin ASODN group when compared with that of others.Nude mice of survivin ASODN group showed lower growth index and tumor inhabiting rate was significantly higher than that of other groups (P < 0.05).Transplanted tumor on nude mice in control group (blank),Lip group,and survivin SODN group grew bigger as time passed and there was no significance among them (P > 0.05).We found a great deal of tumor cell necrosis in survivin ASODN group.No death of nude mice was observed in all 4 groups and we did not found obvious lesion in vital organs.Conclusion:Survivin ASDON could be used for the inhibitation of subcutaneously transplanted tumor in nude mice without obvious lesion in vital organs. | Weiwei Wang Shaojia Wang Gaofeng Li Lei Li Ruibing Cheng | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，6： | 0 |
| 19 | Synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting显示文摘Due to its simplicity, high efficiency, and chemo-selectivity, bioorthogonal chemistry has shown a great application potential in pre-targeting.Currently, four bioorthogonal pairs as targeting tools, including (strept)avidin/biotin, antibody/antigen, oligonucleotide hybridization and IEDDA tools, have been developed and applied in targeted delivery.Nevertheless, all of these tools still suffer from some limitations, such as difficult modification, biochemical fragility and larger molecular weight for biological association tools, as well as chemical instability for IEDDA tools.Synthetic host-guest pairs with relatively small molecular sizes not only possess strong chemical stability, but also have the features of fast conjugation rate, tunable binding affinity , easy modification, and high chemo-selectivity.Consequently, they can be used as a novel non-covalent bioorthogonal tool for pre-targeting.In order to further promote the development of host-guest pairs as novel bioorthogonal tools for pre-targeted delivery, we firstly calculate their conversion rate to make researcher aware of their unique advantages;next, we summarize the recent research progress in this area.The future perspectives and limitations of these unique tools will be discussed.This review will provide a systemic overview of the development of synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting, and may serve as a “go for” resort for researchers who are interested in searching for new synthetic tools to improve pre-targeting. | Yan-Long Ma Shi Yan Xiong-Jie Xu Hua Cao Ruibing Wang | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 20 | Responsive Trimodal Probes for In Vivo Imaging of Liver Inflammation by Coassembly and GSH-Driven Disassembly显示文摘Noninvasive in vivo imaging of hepatic glutathione(GSH)levels is essential to early diagnosis and prognosis of acute hepatitis.Although GSH-responsive fluorescence imaging probes have been reported for evaluation of hepatitis conditions,the low penetration depth of light in liver tissue has impeded reliable GSH visualization in the human liver.We present a liver-targeted and GSH-responsive trimodal probe(GdNPs-Gal)for rapid evaluation of lipopolysaccharide-(LPS-)induced acute liver inflammation via noninvasive,real-time in vivo imaging of hepatic GSH depletion.GdNPs-Gal are formed by molecular coassembly of a GSH-responsive Gd(III)-based MRI probe(1-Gd)and a liver-targeted probe(1-Gal)at a mole ratio of 5/1(1-Gd/1-Gal),which shows high r_(1) relaxivity with low fluorescence and fluorine magnetic resonance spectroscopic(^(19)F-MRS)signals.Upon interaction with GSH,1-Gd and 1-Gal are cleaved and GdNPs-Gal rapidly disassemble into small molecules 2-Gd,2-Gal,and 3,producing a substantial decline in r_(1) relaxivity with compensatory enhancements in fluorescence and ^(19)F-MRS.By combining in vivo magnetic resonance imaging(^(1)H-MRI)with ex vivo fluorescence imaging and ^(19)F-MRS analysis,GdNPs-Gal efficiently detect hepatic GSH using three independent modalities.We noninvasively visualized LPS-induced liver inflammation and longitudinally monitored its remediation in mice after treatment with an anti-inflammatory drug,dexamethasone(DEX).Findings highlight the potential of GdNPs-Gal for in vivo imaging of liver inflammation by integrating molecular coassembly with GSH-driven disassembly,which can be applied to other responsive molecular probes for improved in vivo imaging. | Yuxuan Hu Yuqi Wang Xidan Wen Yifan Pan Xiaoyang Cheng Ruibing An Guandao Gao Hong-Yuan Chen Deju Ye | 2020 | Research2020，，1： | 0 |
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