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您的检索式：作者名="Caiwei Shen"
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| 1 | Kirigami-inspired,highly stretchable microsupercapacitor patches fabricated by laser conversion and cutting显示文摘The recent developments in material sciences and rational structural designs have advanced the field of compliant and deformable electronics systems.However,many of these systems are limited in either overall stretchability or areal coverage of functional components.Here,we design a construct inspired by Kirigami for highly deformable microsupercapacitor patches with high areal coverages of electrode and electrolyte materials.These patches can be fabricated in simple and efficient steps by laser-assisted graphitic conversion and cutting.Because the Kirigami cuts significantly increase structural compliance,segments in the patches can buckle,rotate,bend and twist to accommodate large overall deformations with only a small strain(<3%)in active electrode areas.Electrochemical testing results have proved that electrical and electrochemical performances are preserved under large deformation,with less than 2%change in capacitance when the patch is elongated to 382.5%of its initial length.The high design flexibility can enable various types of electrical connections among an array of supercapacitors residing in one patch,by using different Kirigami designs. | Renxiao Xu Anton Zverev Aaron Hung Caiwei Shen Lauren Irie Geoffrey Ding Michael Whitmeyer Liangjie Ren Brandon Griffin Jack Melcher Lily Zheng Xining Zang Mohan Sanghadasa Liwei Lin | 2018 | Microsystems & Nanoengineering2018，4，1： | 6 |
| 2 | Characterization of SARS-COV-2 main protease inhibitory peptides from Ulva prolifera proteins显示文摘The main protease(M^(pro))is essential for the replication of SARS-COV-2 and therefore represents a promising anti-viral target.In this study,we screened M^(pro)inhibitory peptides from Ulva prolifera protein on in-silico proteolysis.Cytotoxicity analysis using the online toxic prediction tool ToxinPred revealed that all the peptides were non-cytotoxic.The hexapeptide(SSGFID)exhibited high M^(pro)inhibitory activity in molecular docking and its IC_(50)value was 139.40±0.82μmol/L in vitro according to fluorescence resonance energy transfer assay(FRET).Quantitative real-time(qRT-)PCR results show that SSGFID could stimulate the expression of mitosis-related factors,including nuclear factor-κB,cyclin D1,and cyclin-dependent kinase 4,to promote the proliferation of mice splenocytes.Stability study revealed that SSGFID showed resistance against pepsin and trypsin but lost D(Asp)after pretreatment at121℃ for 15 min.Besides,SSGFID was mainly transported through the Caco-2 cell monolayer by the peptide transporter PepT1 and passive-mediated transport during the transport study.Unfortunately,the peptide was also degraded by Caco-2 intracellular enzymes,and the transfer rate of intact peptide was4.2%.Furthermore,Lineweaver–Burk plots demonstrated that SSGFID possessed a mixed inhibitory characteristic with M^(pro).Our study indicated the potential of Ulva prolifera as antiviral and immuneenhancing functional food ingredients and nutraceuticals. | Zhiyong LI Yehua WANG Caiwei FU Dongren ZHANG Tuanjie CHE Songdong SHEN | 2023 | Journal of Oceanology and Limnology2023，41，5： | 0 |
| 3 | Study of screening,transport pathway,and vasodilation mechanisms on angiotensin-Ⅰconverting enzyme inhibitory peptide from Ulva prolifera proteins显示文摘In this study,Ulva prolifera protein was used for preparing angiotensin-I converting enzyme(ACE)-inhibitory peptide via virtual gastrointestinal digestion and in silico screening.Some parameters of the obtained peptide,such as inhibition kinetics,docking mechanism,stability,transport pathway,were explored by Lineweaver-Burk plots,molecular docking,in vitro stimulate gastrointestinal(GI)digestion and Caco-2 cells monolayer model,respectively.Then,a novel anti-ACE peptide LDF(IC_(50),(1.66±0.34)μmol/L)was screened and synthesized by chemical synthesis.It was a no-competitive inhibitor and its anti-ACE inhibitory effect mainly attributable to four Conventional Hydrogen Bonds and Zn701 interactions.It could keep activity during simulated GI digestion in vitro and was transported by peptide transporter PepT1 and passive-mediated mode.Besides,it could activate Endothelial nitric oxide synthase(eNOS)activity to promote the production of NO and reduce Endothelin-1(ET-1)secretion induced by AngiotensinⅡ(AngⅡ)in Human Umbilical Vein Endothelial Cells(HUVECs).Meanwhile,it could promote mice splenocytes proliferation in a concentration-dependent manner.Our study indicated that this peptide was a potential ingredient functioning on vasodilation and enhancing immunity. | Zhiyong Li Yuan He Hongyan He Caiwei Fu Mengru Li Aiming Lu Dongren Zhang Tuanjie Che Songdong Shen | 2023 | Acta Oceanologica Sinica2023，42，11： | 0 |
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