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| 1 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 2 | Rearrangement and expression of the immunoglobulin μ-chain gene in human myeloid cells显示文摘 | Jing Huang Xiaoping Sun Xiaoting Gong Zhiqiao He Lei Chen Xiaoyan Qiu C Cameron Yin | 2014 | Cellular & Molecular Immunology2014，11，1： | 5 |
| 3 | Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells显示文摘The restriction of immunoglobulin(Ig)expression to B lymphocytes is well established.However,several reports have confirmed that the Ig gene can be expressed in many non-B cancer cells and/or some normal cells.Our aim is to determine whether the Ig gene promoter can be activated in non-B cancer cells and to identify the regulatory mechanism for Ig gene expression.Our results show that the Ig promoter of VH4-59 was activated in several non-B cancer cell lines.Moreover,two novel positive regulatory elements,an enhancer-like element at 2800 to 2610 bp and a copromoter-like element at 2610 to 2300 bp,were identified in two epithelial cancer cell lines,HeLa S3 and HT-29.The octamer element(59-ATGCAAAT-39)located in the Ig promoter,a crucial element for B-cell-derived Ig gene transcription,was also very important for non-B-cell-derived Ig gene transcription.More importantly,we confirmed that octamer-related protein-1(Oct-1),but not Oct-2,was a crucial transcriptional factor for Ig gene transcription due to its ability to bind to the octamer element of the Ig promoter in epithelial cancer cells.These results suggested the presence of a distinct regulatory mechanism for Ig gene expression in non-B cancer cells. | Xiaohui Zhu Lina Wu Li Zhang Peng Hao Shuai Zhang Jing Huang Jie Zheng Yinan Liu Wenjun Li Yingmei Zhang Chunyan Zhou Youhui Zhang C Cameron Yin Xiaoyan Qiu | 2010 | Cellular & Molecular Immunology2010，7，4： | 5 |
| 4 | Reuse of liver grafts following the brain death of the initial recipient显示文摘AIM: To determine if there is a reasonable prospect of success of a re-use liver transplantation.METHODS: We systematically searched for reports of liver graft re-use using electronic searches of PubMed and Web of Knowledge. We performed hand searches of references lists of articles reporting re-use of grafts.RESULTS: A systematic review of the literature reveals 28 liver transplantations using previously transplanted grafts. First and second recipients ranged in age from 4 to 72 years and 29 to 62 years respectively. Liver disease in the first recipient was varied including 5(18%) patients with fulminant liver failure who died subsequently of cerebral edema. The second transplanta-tion was performed after a median interval of 5 d(one day-13 years). Viral hepatitis was present in 3(11%) of the initial recipients and in 8(29%) of final recipients. Hepatocellular carcinoma was present in 6(21%) of the final recipients. Early survival after the final transplantation was 93%, whereas long-term survival was 78% with a mean follow-up of 23.3(3-120) mo.CONCLUSION: Outcomes of transplantation using previously transplanted grafts in this select population are similar to those seen with conventional grafts. | Hideaki Tanaka Vivian C McAlister Mark A Levstik Cameron N Ghent Paul J Marotta Douglas Quan William J Wall | 2014 | World Journal of Hepatology2014，6，6： | 3 |
| 5 | 跨音速转子叶顶泄漏流/主流交界面的前移机制显示文摘采用数值计算和实验研究相结合的方法,研究了跨音速转子叶顶泄漏流与主流交界面轴向位置随流量的变化规律和机制。该跨音转子是美国圣母大学一级半跨音速压气机转子。研究发现机匣壁面脉线分布能够定性反映壁面轴向剪切应力分布,可用来识别叶顶泄漏流与主流的交界面位置。通过机匣壁面的脉线分布,可以看出机匣壁面存在两条零剪切应力线。第一条零剪切应力线表示来流与叶顶泄漏流之间交界面的时间和周向平均轴向位置,在小流量工况下交界面靠近顶部叶片的前缘。计算和实验结果都表明,随着质量流量的减小,叶顶泄漏流与主流交界面的轴向位置不断向叶片前缘移动。在近失速点,交界面到达叶片前缘,泄漏流即将溢出。泄漏流与主流的轴向动量比随流量减小不断增大的变化规律进一步说明,间隙区域泄漏流与主流的轴向动量平衡是导致交界面不断前移直至溢出的内在机制。 | 杜娟 林峰 陈静宜 Mark H Ross Joshua D Cameron Scott C Morris | 2011 | 工程热物理学报2011，32，6： | 3 |
| 6 | Metabolic engineering of propanediol pathways显示文摘 | Altaras N E Hoffman M L | 1998 | Biotechnology Progress1998，14，1： | 1 |
| 7 | TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA显示文摘 | CHOCKALINGAM A BROOKS J C CAMERON J L | 2009 | Immunol Cell Biol2009，87，3： | 1 |
| 8 | Should you cancel the operation when a child has an upper respiratory tract infection?显示文摘 | COHEN M M CAMERON C B | 1991 | Anesth Analg1991，72，： | 1 |
| 9 | Response and modeling of cantilever retaining walls subjected to seismic motions显示文摘 | GREEN R A OLGUN C G CAMERON W I | 2008 | Computer-Aided Civil and Infrastructure Engineering2008，23，4： | 1 |
| 10 | Do preoperative biliary stents increase postpancreaticoduodenectomy complicatioas?显示文摘 | SOHN TA YEO C J CAMERON JL | 2000 | J Gastrointest Surg2000，4，4： | 1 |
| 11 | Six hundred filly consecutive panereaticoduodenectomies in the 1990s: Pathology complication, and outcomes显示文摘 | Yeo C J Cameron JL Sohn TA | 1997 | Ann Surg1997，226，3： | 1 |
| 12 | Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications,and outcomes 显示文摘 | Yeo C J Cameron JL Sohn TA | 1997 | Aun Surg1997，226，3： | 1 |
| 13 | Continuing mefformin throughout pregnancy in women with polycystie ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study 显示文摘 | Glueek C J Phillips H Cameron D | 2001 | Fertil Steril2001，75，1： | 1 |
| 14 | A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase显示文摘 | Hong Z Cameron C E Walker M P | 2001 | Virology2001，285，： | 1 |
| 15 | Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s:pathology, complications, and outcomes显示文摘 | Yeo C J Cameron JL Sohn TA | 1997 | Ann Surg1997，226，3： | 1 |
| 16 | Improving 1,3-propanediol production from glycerol in a metabolically engineered Escherichia coli by reducing accumulation of sn-Glycerol-3-phosphate显示文摘 | Zhu M M Lawmnan P D Cameron D C | 2002 | Biotechnol Prog2002，18，4： | 1 |
| 17 | Changes in mineral N,microbial biomass and enzyme activity in different soil depths after surface applications of dairy shed effluent and chemical fertilizer显示文摘 | ZAMAN M CAMERON K C DI H J | 2002 | Nutrient Cycling in Agroecosystems2002，63，2： | 1 |
| 18 | Calculating nitrogen leaching losses andcritical nitrogen application rates in dairy pasture systems using a se-mi-empirical model显示文摘 | DI H J CAMERON K C | 2000 | New Zealand Journal of AgriculturalReaearch2000，43，： | 1 |
| 19 | Nitrate removal from three different effluents using large-scale denitrification beds显示文摘 | Schipper L A Cameron S C Warneke S | 2010 | Ecological Engineering2010，36，11： | 1 |
| 20 | Ribavirin's antiviral mechanism of action: lethal mutagenesis? 显示文摘 | Crotty S Cameron C Andino R | 2002 | J Mol Med (Berl)2002，80，2： | 1 |
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