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| 1 | Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review显示文摘AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: 'NASH', 'NAFLD', 'nonalcoholic steatohepatitis', 'non-alcoholic fatty liver disease', 'fat', 'steatosis', 'diet', 'exercise', 'MR spectroscopy' and 'liver biopsy'. NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. | Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi | 2016 | World Journal of Gastroenterology2016，22，27： | 30 |
| 2 | MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma显示文摘Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey | 2010 | World Journal of Gastroenterology2010，16，5： | 23 |
| 3 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 4 | Arthroscopic treatment options for irreparable rotator cuff tears of the shoulder显示文摘The management of patients with irreparable rotator cuff tears remains a challenge for orthopaedic surgeons with the final treatment option in many algorithms being either a reverse shoulder arthroplasty or a tendon transfer. The long term results of these procedures are however still widely debated, especially in younger patients. A variety of arthroscopic treatment options have been proposed for patients with an irreparable rotator cuff tear without the presence of arthritis of the glenohumeral joint. These include a simple debridement with or without a biceps tenotomy, partial rotator cuff repair with or without an interval slide, tuberplasty, graft interposition of the rotator cuff, suprascapular nerve ablation, superior capsule reconstruction and insertion of a biodegradable spacer(Inspace) to depress the humeral head. These options should be considered as part of the treatment algorithm in patients with an irreparable rotator cuff and could be used as either as an interim procedure, delaying the need for more invasive surgery in the physiologically young and active, or as potential definitive procedures in the medically unfit.The aim of this review is to highlight and summarise arthroscopic procedures and the results thereof currently utilised in the management of these challenging patients. | Cameron M Anley Samuel KL Chan Martyn Snow | 2014 | World Journal of Orthopedics2014，5，5： | 8 |
| 5 | Grammar_based definition of metaprogramming system 显示文摘 | Cameron Robert D Robert Ito M | 1984 | ACM Transactions on Programming Languages and System1984，6，1： | 2 |
| 6 | Medicine prices, availability, and affordability in 36 developing and middle-income countries: a secondary analysis显示文摘 | A Cameron M Ewen D Ross-Degnan D Ball R Laing | 2009 | 2009 (9659)2009，，9659： | 2 |
| 7 | Large artery stiffness predicts ischemic threshold in patients with coronary artery disease显示文摘 | Bronwyn A Kingwell Tamara K Waddell Tanya L Medley James D Cameron Anthony M Dart | 2002 | Journal of the American College of Cardiology2002，，4： | 2 |
| 8 | Recurrent calcium nephrolithiasis associated with primary aldosteronism 显示文摘 | Shey J Cameron M A Sakhaee K | 2004 | Am J Kidney Dis2004，44，1： | 1 |
| 9 | Exploration of die wall friction for powder compaction using a discrete finite element modelling technique显示文摘 | Gethin D T | 2001 | Modelling and Simulation in Materials Science and Engineering2001，9，： | 1 |
| 10 | Metabolic engineering of propanediol pathways显示文摘 | Altaras N E Hoffman M L | 1998 | Biotechnology Progress1998，14，1： | 1 |
| 11 | Novel Cell Culture Device Enabling Three-Dimensional Cell Growth and hnproved Cell Function 显示文摘 | Bokhari M Camachan R J Cameron N R | 2007 | Biochem Biophys Res Comnmn2007，354，4： | 1 |
| 12 | Should you cancel the operation when a child has an upper respiratory tract infection?显示文摘 | COHEN M M CAMERON C B | 1991 | Anesth Analg1991，72，： | 1 |
| 13 | Adenocarcinoma of the esophagogastric junction and Barrett's esophagus 显示文摘 | Cameron A J Lomboy CT Pera M | 1995 | Gastroenterology1995，109，5： | 1 |
| 14 | 1423 panereaticodu- odenetomies for pancreatic cancer: a single-institution experience 显示文摘 | Winter M Cameron ]L Campbell KA | 2006 | J Gastrointest Surg2006，10，9： | 1 |
| 15 | Military movement training program improves jump-landing mechanics associated with anterior crueiate ligament injury risk 显示文摘 | Owens B D Cameron K L Duffey M L | 2012 | Journal of surgical orthopaedic advances2012，22，1： | 1 |
| 16 | Finding deeply-buried deposits using geochemistry显示文摘 | Cameron E M Hamilton S M Leyboume M I | 2004 | Geochemistry: Exploration Environment Analysis2004，4，1： | 1 |
| 17 | Recovery of retrograde condensed liquids by re-vaporization during dry gas injection显示文摘 | Sigmund P M Cameron A M | 1977 | JCPT1977，16，1： | 1 |
| 18 | Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction显示文摘 | Pera M Cameron AJ Trastek VF | 1993 | Gastroenterology1993，104，2： | 1 |
| 19 | Robust design optimization of structures through consideration of variation显示文摘 | Sandgren E Cameron T M | 2002 | Computers and Structures2002，80，2021： | 1 |
| 20 | A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase显示文摘 | Hong Z Cameron C E Walker M P | 2001 | Virology2001，285，： | 1 |
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