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| 1 | Expressions of GSK-3beta,Beta-Catenin and PPAR-Gamma in Medulloblastoma显示文摘Objective:To investigate the expressions of GSK-3beta,Beta-catenin and PPAR-gamma,and their relationship in medulloblastoma,and to explore their value in clinic application. Methods:Immunohistochemical staining with SP method was conducted to determine the expressions of GSK-3beta,Beta-catenin and PPAR-gamma in 48 cases of medulloblastoma and 10 normal cerebellar tissues. Results:The rate of abnormal expressions of beta-catenin and PPAR-gamma in MB was higher than that in normal. Conversely,GSK-3beta in MB was lower than that in the normal (P<0.05). Furthermore,in medulloblastoma,beta-catenin and GSK-3beta showed a negative correlation,PPAR-gamma and beta-catenin had a positive correlation. Conclusion:Abnormal expression of beta-catenin plays a crucial role in the development of medulloblastoma. Meanwhile,PPAR-gamma and GSK-3beta which are tightly related with beta-catenin are both involved in the genesis and development of medulloblastoma. | Xiong Zhang Lu Si Yu Li Can Mi | 2009 | Chinese Journal of Cancer Research2009，21，3： | 2 |
| 2 | Primary Testicular NK/T-Cell Lymphoma:A Study of Two Cases and Review of Literature显示文摘Primary testicular NK/T-cell lymphoma is an extremely rare entity progressed rapidly.The aim of this study was to examine clinical and pathological features of primary testicular NK/T-cell lymphoma and to investigate the effective diagnosis and prognosis.In this paper,the two cases of primary testicular NK/T-cell lymphoma were observed by light microscopy,immunohistochemistry and examined by in situ hybridization for Epstein-Barr Virus(EBV) DNA and the literatures were reviewed.The two patients respectively present with bilateral and right-side painless testicular enlargement.The morphology of neoplastic cells of case 1 were small to medium,tumor cells of case 2 were small,medium and large mixed.The tumor cells grew diffusely with irregular and distort nuclear,destructed the organizational structure of the normal testis,and damaged blood vessels,meanwhile,coagulation necrosis was exist.Immunohistochemical staining of neoplastic cells showed positive for CD45,CD2,CD56,CD3ε(cytoplasm staining pattern),CD45RO and Granzyme B,and negative for CD57,CD20,CD79α,CD30,CK,MPO,TdT,Bcl-2 and PLAP were negative.In addition,the EBV DNA was detected in the lymphoma by In situ hybridization.In conclusion,the expression of CD56,CD3ε,and Granzyme B associated proteins and EBV examination by in situ hybridization play a vital role in diagnosis and differential diagnosis of primary testicular NK/T-cell lymphoma. | Xiao Lin Dan Li Peng Xie Can Mi Qing Lin | 2010 | Chinese Journal of Cancer Research2010，22，3： | 1 |
| 3 | Recombinant E.coli LLO/OVA Vaccination Effectively Inhibits Murine Melanoma Metastasis to Lung by CD8^+T Cells Immunity显示文摘Objective:To construct recombinant E.coli LLO/OVA and investigate its tumor metastatic inhibition effect in B16 OVA melanoma challenged mice. Methods:Recombinant E.coli LLO/OVA was constructed and the expression of listeriolysin O(LLO) and ovalbumin(OVA) of the vaccine was determined by coomassie brilliant blue staining and western blotting. After 3 subcutaneous injections of E.coli LLO/OVA,the percentages of CD3+CD4+T,CD4+CD25+T,CD3+CD8+T and OVA257-264 SIINFEKL specific CD8+T cells were determined by flow cytomytry,and the tumor metastatic inhibition effect in B16 OVA melanoma challenged mice was observed. Results:Recombinant E.coli LLO/OVA was successfully constructed,and the expression of LLO and OVA of the vaccine was confirmed. After 3 subcutaneous injections of E.coli LLO/OVA and E.coli OVA in mice,the percentages of CD3+CD4+T,CD4+CD25+T and CD3+CD8+T cells were equivalent in the two groups of mice. However,there were significantly more OVA257-264 SIINFEKL specific CD8+T cells in E.coli LLO/OVA vaccinated mice than that in E.coli OVA vaccinated mice. The prophylactic E.coli LLO/OVA vaccination effectively prevented the tumor metastasis to lungs in B16 OVA melanoma challenged mice. Depletion of CD8+T cells significantly impaired the tumor inhibition effect of the vaccine in B16 OVA challenged mice. The therapeutic vaccination of E.coli LLO/OVA significantly prevented melanoma metastasis to lungs in B16 OVA challenged mice too. Conclusion:Recombinant E.coli LLO/OVA vaccination is highly effective in inhibiting murine malignant melanoma metastasis by promoting CD8+T cell immunity. | Man Xu Ming-shen Dai Can Mi | 2009 | Chinese Journal of Cancer Research2009，21，1： | 1 |
| 4 | Primary testicular diffuse large B-cell lymphoma shows an activated B-cell-like phenotype显示文摘 | Dan Li Peng Xie Can Mi | 2010 | Pathology - Research and Practice2010，，9： | 1 |
| 5 | The promotion of endothelial progenitor cells recruitment by nerve growth factors in tissue-engineered blood vessels显示文摘 | Wen Zeng Wei Yuan Li Li Jianhong Mi Shangcheng Xu Can Wen Zhenhua Zhou Jiaqiang xiong Jiansen Sun Dajun Ying Mingcan Yang Xiaosong Li Chuhong Zhu | 2009 | Biomaterials2009，，7： | 1 |
| 6 | Distribution and bioavailability of rare earth elements in aquatic microcosm 显示文摘 | Yang Xingye Yin Daqiang Sun Hao Wang Xiaorong Dai Lemei Chen Yijun Can Mi | 1999 | Chemosphere1999，39，14： | 1 |
| 7 | Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action 显示文摘 | Can R Bjorndahl MA Gallego MI Chen S Religa P Hansen A J | 2006 | Blood2006，107，9： | 1 |
| 8 | Purification and characterization of a novel NADH-dependent carbonyl reductase from Pichia stipitis involved in biosynthesis of optically pure ethyl (S)-4-chloro-3-hydroxybutanoate显示文摘 | Can H Mi L Ye Q | 2011 | Bioresour Technol2011，102，2： | 1 |
| 9 | Extraskeletal myxoid chondrosarcoma: A clinicopathological study of six cases 显示文摘 | Mi Can | 1991 | Chin J Pathol1991，4，： | 1 |
| 10 | A novel multi-threshold coupling InAlN/GaN double-channel HEMT for improving transconductance flatness显示文摘GaN-based HEMTs have significant advantages,making them a prime choice for high-frequency,high-power switching [1].However,the inherent poor linearity of GaN HEMT has yet to be solved,which can be reflected by the nonlinearity of the transconductance (Gm) profile [2].This makes it hard to achieve high data transmission efficiency and less signal distortion in the wireless communication system [3]. | Sirui AN Minhan MI Pengfei WANG Sijia LIU Qing ZHU Meng ZHANG Zhihong CHEN Jielong LIU Siyin GUO Can GONG Xiaohua MA Yue HAO | 2024 | Science China(Information Sciences)2024，67，1： | 0 |
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