|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | High adiponectin levels fail to protect against the risk of hypertension and,in women,against coronary disease:involvement in autoimmunity?显示文摘AIM:To investigate whether serum adiponectin protects against cardiometabolic risk in a population sample with prevailing metabolic syndrome.METHODS:Middle-aged adults representative of a general population with baseline circulating adiponectin measurements(n=1224)were analyzed prospectively at a mean of 3.8 years’follow-up,using continuous values or sex-specific tertiles.Total adiponectin was assayed by an ELISA kit.Type-2 diabetes was identified by criteria of the American Diabetes Association.Hypertension was defined as a blood pressure≥140 mmHg and/or≥90 mmHg and/or use of antihypertensive medication.Outcomes were predicted using Cox proportional hazards regression analysis in models that were controlled for potential confounders.RESULTS:In models of multiple linear regression,sex hormone-binding globulin,fasting insulin(inverse)and,in men,age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum creatinine.Cox regression analyses for incident coronary heart disease(CHD),adjusted for sex,age,non-HDL cholesterol,waist circumference and C-reactive protein,revealed significant inverse association with adiponectin tertiles in men but not women(HR=0.66;95%CI:0.32-1.38 for highest tertile).Cox regression for type-2 diabetes in a similar model(wherein glucose replaced non-HDL cholesterol),adiponectin tertiles appeared to protect in each gender.HR for incident hypertension roughly displayed unity in each of the adiponectin tertiles(P-trend=0.67).CONCLUSION:High adiponectin levels failed to protect against the development of hypertension and,in women,against CHD,presumably paralleling impairment in renal function as well.Involvement of adiponectin in autoimmune complex with loss of antioxidative-antiatherogenic properties may be underlying. | Altan Onat Mesut Aydln Günay Can Bayram Kroglu Ahmet Karagz Servet Altay | 2013 | World Journal of Diabetes2013，4，5： | 3 |
| 2 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 3 | Characterization of polyphenol oxidase from litchi pericarp using ( - ) - epicatechin as substrate 显示文摘 | Liu L Can S Xie B Sun Z Li X Miao W | 2007 | Journal of Agriculture and Food Chemistry2007，55，17： | 1 |
| 4 | Adsorption of boron from aqueous solutions by activated carbon impregnated with salicylic acid: Equilibrium, kinetic and thermodynamic studies显示文摘 | CAN BZ CEYLAN Z KOCAKERIM M M | 2012 | Desalination and Water Treatment2012，40，123： | 1 |
| 5 | Modeling study on absorption of CO2 by aqueous solutions of N-methyidiethanolamine in rotating packed bed显示文摘 | Qian Z Xu L B Can H B | 2009 | Ind Eng Chem Res2009，48，20： | 1 |
| 6 | Specific ablation of the apototic functions of cytochrome c reveals a differential requirement for cytochrome c and apaf-1 in apoptosis显示文摘 | Hao Z Gordorn S Can D | 2005 | Cell2005，121，4： | 1 |
| 7 | Spectroscopic, stability and antioxidant properties of a novel pigment from Gardenia显示文摘 | Yang C Le C Can Z | 2008 | Food Chemistry2008，109，： | 1 |
| 8 | Lumbar stiffness but not thoracic radiographic changes relate to alteration of lung function tests in ankylosing spondylitis 显示文摘 | Cerrahoglu L Unlu Z Can M | 2002 | Clin R_heumatol2002，21，4： | 1 |
| 9 | General features of gastric carcino-mas and comparison of HSP70 and NK cell immunoreactivity withprognostic factors显示文摘 | Canz O Belenli O Patiroglu TE | 2002 | Pathol Oncol Res2002，8，4： | 1 |
| 10 | Spectroscopic, stability and antioxi- dant properties of a novel pigment from Gardenia 显示文摘 | Yang C Le C Can Z | 2008 | Food Chem2008，109，： | 1 |
| 11 | The quality of life and self - effica- cy of Turkish breast cancer patients undergoing chemotherapy 显示文摘 | Akin S Can G Durna Z | 2008 | Euro J Oncol Nurs2008，12，5： | 1 |
| 12 | CuC12 immobilized on amino-functionalized MCM-41 and MCM-48 and their catalytic performance toward the vapor-phase oxy-carbonylation of methanol to dimethylcarbonate显示文摘 | Yuan Y Z Can W Weng W Z | 2004 | Journal of Catalysis2004，228，： | 1 |
| 13 | Effect of nitrite ions on steel corrosion induced by chloride or sulfate ions 显示文摘 | Can Z Hibinn M Goda H | 2013 | International Journal of Corrosion2013，，2013： | 1 |
| 14 | Quantitative evaluation of the axonal degeneration of central motor neurons in chronic cerebral stroke with diffusion tensor imaging显示文摘 | Can L Hai-Chun Z Xiao-Hui M | 2013 | Acta Radiologica2013，55，： | 1 |
| 15 | Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy 显示文摘 | Yang L Can Z Yan H | 2003 | Cancer Res2003，63，20： | 1 |
| 16 | The quality of life and self-efficacy of Turkish breast cancer patients undergoing chemotherapy显示文摘 | Akin S Can G Durna Z | 2008 | Eur J Oncol Nursing2008，12，5： | 1 |
| 17 | The quality of life and self - efficacy of Turkish breast cancer patients undergoing chemotherapy 显示文摘 | Akin S Can G Duma Z | 2008 | Eur J Oncol Nurs2008，12，5： | 1 |
| 18 | The quality of litle and self - elficacy of Turkish breast cancer patients undergoing chemotherapy显示文摘 | Akin S Can G Durna Z | 2008 | Europe- an Journal of Oncology Nursing2008，12，5： | 1 |
| 19 | The quality of life and self- effica cy of Turkish breast cancer patients undergoing chemotherapy 显示文摘 | Akin S Can G Duma Z et a l | 2008 | European Journal of Oncology Nursing2008，12，： | 1 |
| 20 | An Investigation of X-ray Escape for an HPGe Detector显示文摘 | Cüneyt Can Serdar Z B | 2003 | X-Ray Spectrom2003，32，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员