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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 3 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 4 | Fabrication Technology for Single-material MEMS Using Polycrystalline Diamond显示文摘 | Cao Z L Aslam D | 2010 | Diamond & Related Materials2010，19，10： | 1 |
| 5 | Mutations in PA3574( nalD)lead to increased MexAB-OprM expression and multidrug resist-ance in laboratory and clinical isolates of Pseudomonas aeruginosa显示文摘 | Sobel ML Hocquet D Cao L | 2005 | Antimicrob Agents Chemother2005，49，5： | 1 |
| 6 | The effect of exercise training on the metabolic interaction between digestion and locomotion in juvenile darkbarbel catfish (Peltebagrus vachelli) 显示文摘 | Li X M Cao Z D Peng J L | 2010 | Comparative Biochemistry and Physiology Part A2010，156，1： | 1 |
| 7 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
| 8 | Cognitive performance and plasma levels of homocysteine, vitamin B12, folate and lipids in patients with Alzheimer disease 显示文摘 | LI L CAO D DESMOND R | 2008 | Dement Geriatr Cogn Disord2008，26，4： | 1 |
| 9 | 查看详情显示文摘 | Wu D J Cao L Ke S Z | | 0，，： | 1 |
| 10 | 查看详情显示文摘 | Wang G E Qin W P Zhang J S Zhang J S Wang Y Cao C Y Wang L L Wei G D Zhu P E Wu C E Kim Ryongjin | | 0，，： | 1 |
| 11 | Synthesis of an ultrafine grained TiAl based alloy by subzero temperature milling and HIP: Its microstructure and mechanical properties 显示文摘 | YU H B ZHANG D L CHEN Y Y CAO P GABBITAS B | 2009 | Journal of Alloys and Compounds2009，474，12： | 1 |
| 12 | 显示文摘 | Butler P E Cao Y L | 1998 | Plast Reconstr Swry1998，10，6： | 1 |
| 13 | First-order-like transition for colored-noise saturation models of dye lasers显示文摘 | Cao L Wu D | 1993 | Phys Rev1993，48，1： | 1 |
| 14 | Electrochemical behavior of Mg-Li, Mg-Li-AI and Mg-Li-AI-Ce in sodium chloride solution显示文摘 | CAO D WU L SUN Y | 2008 | J Power Sources2008，177，： | 1 |
| 15 | Comparison of dissolved organic matter from sewage sludge and sludge compost as electron shuttles for enhancing Fe(III) bioreduction显示文摘 | Huang D Y Zhuang L Cao W D | 2010 | Journal of Soils and Sediments2010，10，4： | 1 |
| 16 | Seismic performance of RC shear walls with concealed bracing显示文摘 | Cao W L Xue S D Zhang J W | 2003 | Advances in Structural Engineering2003，6，1： | 1 |
| 17 | Use of fly ash as an admixture for electromagnetic interference shielding显示文摘 | CAO J Y CHUNG D D L | 2004 | Cement & Concrete Research2004，34，10： | 1 |
| 18 | A pilot study of subjects recovered from hemiparetic stroke 显示文摘 | Cao Y D'Olhaberriague L Vikingstad EM | 1997 | Stroke1997，28，： | 1 |
| 19 | Effect of temperature on swimming performance in juvenile southern catfish (Silurus meridionalis Chen) 显示文摘 | Zeng L Q Cao Z D Fu S J | 2009 | Comparative Biochemistry and Physiology A2009，153，2： | 1 |
| 20 | J Chemom显示文摘 | Cao D SiLiang Y Z Xu Q S Zhang L X Hu Q N Li H D | 2011 | 25(4):2012011，25，4： | 1 |
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