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| 1 | Comprehensive review of autoantibodies in patients with hyper-IgM syndrome显示文摘Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene.The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis.In the present study,we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome.Serum,liver-related and liver-not-related autoantibodies IgG,IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients(8 males and 5 females,aged 1–12 years)with hyper-immunoglobulin M syndrome during 1995–2012 and,as controls,21 age-and gender-matched blood donors.The level of IgM antibody against MIT3 was significantly higher in patients than in controls(35.8 vs 10.7,P=0.002).Half of the hyperimmunoglobulin M syndrome patients were found to be anti-MIT3 IgM positive vs none of the controls(Po0.0001).Twenty-three percent of patients were found to be anti-sp100 antibody positive vs only 0.05%of controls.By immunofluorescence,92.3%of patients were MIT3 IgM positive vs none of the controls.In conclusion,the IgM class of anti-MIT3 antibodies was shown to be present by both ELISA and immunofluorescence in most of the patients with hyper-immunoglobulin M syndrome.The presence of the hallmark of primary biliary cholangitis,a disease where the CD40 ligand is a key player,in an immunodeficiency disease caused by mutations in the CD40 ligand gene is very intriguing and opens new scenarios in understanding the immune pathogenesis of primary biliary cholangitis. | Mohamed-Ridha Barbouche Qubo Chen Marco Carbone Imen Ben-Mustapha Zakera Shums Mehdi Trifa Federica Malinverno Francesca Bernuzzi Haiyan Zhang Nourhen Agrebi Gary L Norman Christopher Chang M Eric Gershwin Pietro Invernizzi | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 2 | The evolution of raindrop spectra in warm-based convective storms as observed and numerically modeled显示文摘 | Carbone R E Nelson L D | 1978 | J Atmos Sci1978，35，12： | 1 |
| 3 | A model to predict peach phenology and maturity using meteorolgical variables显示文摘 | Schwartz M D Carbone G J Reighard G L | | 0，，02： | 1 |
| 4 | Chemical analysis of flavonoid constituents of the seagrass Halophila stipulacea: First finding of malonylated derivatives in marine phanerogams显示文摘 | Bitam F Ciavatta M L Carbone M | 2010 | Biochemical Systematics and Ecology2010，38，4： | 1 |
| 5 | Microwave-assisted synthesis of colloidal inorganic nanocrystals显示文摘 | Baghbanzadeh M Carbone L Cozzoli PD | 2011 | Angewandte Chemie-International Edition2011，50，11： | 1 |
| 6 | A phase I/II A trial of continuous five-day infusion of squalamine lactate (MSI-1256F) plus carboplatin and paclitaxel in patients with advanced non-small cell lung cancer 显示文摘 | Herbst R S Hammond L A Carbone D P etal | 2003 | Clin Cancer Res2003，9，11： | 1 |
| 7 | LTL model checking for security protocols显示文摘 | Armando A Carbone R Compagna L | 2009 | Journal of Applied Non-Classical Logics2009，19，4： | 1 |
| 8 | Long-term follow- up of video-assisted talc pleurodesis in malignant recurrent pleural effusions 显示文摘 | Gardillo G Facciolo F Carbone L | 2002 | Eur J Cardiothorac Surg2002，21，2： | 1 |
| 9 | Tumor-host immue interactions and dendritic cell dysfunction 显示文摘 | Yang L Carbone DP | 2004 | Adv Cancer Res2004，92，： | 1 |
| 10 | Solitary fibrous tumors of the pleura:an analysis of 110 patients treated in a single institution 显示文摘 | Cardillo G Carbone L Carleo F | 2009 | Ann Thorac Surg2009，88，5： | 1 |
| 11 | Lack of efficacy of oral bovine type Ⅱ collagen added to existing thera- py in rheumatoid arthritis显示文摘 | McKown K M Carbone L D Kaplan S B | 1999 | Arthritis Rheum1999，42，6： | 1 |
| 12 | Fracture risk in patients with ankylosing spondylitis:A population based study显示文摘 | Cooper C Carbone L Michet C J | | 0，，10： | 1 |
| 13 | Solitary fibrous tumors of the pleura: an analysis of 110 patients treated in a single institution显示文摘 | Cardillo G Carbone L Carleo F | 2009 | Ann Thorac Surg2009，88，5： | 1 |
| 14 | Fluoroscopically assisted pedicle screw fixation for thoracic and thoracolumbar injuries显示文摘 | Carbone J J Tortolani P J Quartararo L G | 2003 | Spine2003，28，1： | 1 |
| 15 | Managing the Total Customer Experience显示文摘 | L L Berry L P Carbone H Haeckel | | 0，，03： | 1 |
| 16 | Leakage mechanism in flat seals显示文摘 | BOTTIGLIONE F CARBONE G MANGIALARDI L | 2009 | Journal of Applied Physics2009，106，10： | 1 |
| 17 | Ribosomal DNA sequence divergence within internal transcribed spacer 1 of the Sclerotiniaceae显示文摘 | Carbone I Kohn L M | 1993 | Mycologia1993，85，3： | 1 |
| 18 | Diffuse large B cell lym- phoma:using pathologic and molecular biomarkers to define sub- groups for novel therapy显示文摘 | Carbone A Gloghini A Kwong Y L | 2014 | Ann Hemato12014，93，8： | 1 |
| 19 | Colloidal Heterostructured Nanocrystals: Synthesis and Growth Mechanisms 显示文摘 | Carbone L Cozzoli P D | 2010 | Nano Today2010，5，： | 1 |
| 20 | Solitary fibrous tumors of the pleura:an analysis of 110 patients treated in a single institution显示文摘 | CARDILLO G CARBONE L CARLEO F | 2009 | Ann Thorac Surg2009，88，5： | 1 |
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