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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Evaluation of fruit authenticity and determination of the fruit content of fruit products using FT-NIR spectroscopy of cell wall components显示文摘 | KURZ C LEITENBERGER M CARLE R | 2010 | Food Chemistry2010，119，： | 1 |
| 3 | Design and internal validation of an obstetric early warning score : secondary analysis of the Intensive Care National Audit and Research Centre Case Mix Programme database显示文摘 | Carle C Alexander P Columb M | 2013 | Anaesthesia2013，68，4： | 1 |
| 4 | Comparison of the renal effect of low to high doses of dopamine and dobutamine in critically ill patients:A single -blind randomized study 显示文摘 | Ichai C Soubielle J Carles M | 2000 | Ca''it Care Med2000，28，4： | 1 |
| 5 | 显示文摘 | Greg P S Frederik C K Carl M L | 2008 | Sol Energy Mater Sol Cells2008，92，： | 1 |
| 6 | Prolonged low -dose dopamine in- fusion induces a transient improvement in renal function in hemody- namically stable, critically ill patients: A single - blind, prospective, controlled study显示文摘 | Ichai C Passeron C Carles M | 2000 | Crit Care Med2000，28，： | 1 |
| 7 | Effect of timing of dialysis on mortality in critically ill,septic patients with acute renal failure显示文摘 | Carl DE Grossman C Behnke M | 2010 | Hemodial Int2010，14，1： | 1 |
| 8 | Betalain stability and degradationstructural and chromatic aspects显示文摘 | Kirsten M Herbach Florian C Stintzing Reinholod Carle | 2006 | Journal of Food Science2006，71，4： | 1 |
| 9 | Forebrain ependymal cel s are Notch-dependent and generate neuroblasts and astrocytes after stroke显示文摘 | Carlén M Meletis K G?ritz C | | 0，，03： | 1 |
| 10 | Comparison of racemic albuterol and levalbuterol for treatment of acute asthma显示文摘 | Carl J C Myers T R Kirchner H L Kercsmar C M | 2003 | Pediatr2003，143，： | 1 |
| 11 | Anthropo- metric and fitness characteristics of international, professional and amateur male graduate soccer players from an elite youth academy 显示文摘 | LE GALL F CARLING C WILLIAMS M | 2010 | Sci Med Sport2010，，13： | 1 |
| 12 | Prolonged low-dose dopamine infusion induces a transient improvement in renal function in hemodynamically stable,critically ill patients:a single-blind,prospective,controlled study显示文摘 | Ichai C Passeron C Carles M | 2000 | Crit Care Med2000，28，5： | 1 |
| 13 | Rapid flash annealing of thermally reactive copolymers in a roll-to-roll process for polymer solar cells显示文摘 | Helgesen M Carle J E Andreasen B Hosel M NorrmanK Sondergaard R Krebs F C | 2012 | Polymer Chemistry2012，3，9： | 1 |
| 14 | Betalain stability and deg- radation- Structural and chromatic aspects 显示文摘 | Herbach K M Stintzing F C Carle R | 2006 | JOURNAL OF FOOD SCIENCE2006，71，4： | 1 |
| 15 | Anastomosis group (AG) affinity of pectic isozyme ( zymogram)groups (ZG) of Rhizoctonia solani from the Western Australiancereal-belt显示文摘 | Macnish G C Carling D E Sweetingham M W | 1994 | Mycol Res1994，98，12： | 1 |
| 16 | Effectiveness of part C early intervention physical, occupational, and speech therapy services for preterm or low birth weight infants in Wisconsin, United States 显示文摘 | McManus B M Carle A C Poehlmann J | 2012 | Acad Pediatr2012，12，2： | 1 |
| 17 | Design and fabrication of an integrated microsystem for microcapillary electrophoresis 显示文摘 | CHAN Y C CARLES M SUCHER N J WONG M ZOHAR Y | 2003 | Journal of Micromechanics and Microengineering2003，9，2： | 1 |
| 18 | Mapping freshwater marsh species distributions using WorldView-2 high-resolution multispeetral satellite imagery显示文摘 | Carle M V Wang L Sasser C E | 2014 | International Journal of Remote Sensing2014，35，13： | 1 |
| 19 | Betalain stability and degradation: structural and chromatic aspects显示文摘 | HERBACH K M STINTZING F C CARLE R | 2006 | Journal of Food Science2006，71，4： | 1 |
| 20 | Evaluation of different methods for the production of juice concentrates and fruit powders from cactus pear显示文摘 | MOBHAMMER M R STINTZING F C CARLE R | 2006 | European Food Research and Technology2006，7，4： | 1 |
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