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| 1 | Polyactones:31,Sn (Ⅱ)Octoate-initiated Polymerization of L-lactide:A Mechanistic Study显示文摘 | KRICHELDORF I CAROLINE B | 1995 | Polymer1995，6，36： | 1 |
| 2 | Understanding why women delay in seeking help for breast cancer symptoms显示文摘 | Alison B Amanda R Caroline B | 2005 | Journal of Psychosomatic Research2005，58，： | 1 |
| 3 | The nitric oxide dononr nitropruss ide intraperitoneally affects peritoneal permeability in CAPD显示文摘 | Douma B Dirk R | 1997 | Kidney Int1997，51，： | 1 |
| 4 | Suppressors of cytokine signaling 2 and 3 diametrically control maerophage polarization 显示文摘 | Shaun S Amy F Caroline R B | 2012 | Immunity2012，38，： | 1 |
| 5 | Chromatin acetylation status in the manifestation of neurodegenerative diseases: HDAC inhibitors as therapeutic tools 显示文摘 | Anne- Laurence B Caroline R Irina P | 2007 | Subcell Biochem2007，41，： | 1 |
| 6 | High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy显示文摘BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation therapy.Due to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor growth.Transarterial chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in LT.However,it remains unclear if one of those treatment options is superior.The analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by histopathology.AIM To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT alone.METHODS In this multicenter retrospective study,27 patients who received liver transplantation for HCC were analyzed.Patients received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver transplantation.Liver explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging therapies.Statistical analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U tests.RESULTS Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and SBRT.There were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor lesions.Strikingly,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests that a combination of TACE and SBRT increases the rate of complete histopathological response compared to TACE or SBRT alone in bridging to liver transplantation. | Ulrike Bauer Sabine Gerum Falk Roeder Stefan Münch Stephanie E Combs Alexander B Philipp Enrico N De Toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka Markus Guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
| 7 | Logic Models Used to Enhance Critical Thinking显示文摘 | Caroline R Merle B Lorrie C | 2006 | J Nuts Educ2006，45，6： | 1 |
| 8 | Laparoscopic Sleeve Gastrectomy for a Super-Super-Obese Patient with Situs Inversus Totalis显示文摘 | Jean Marc Catheline MD Caroline Rosales MD Régis Cohen MD PhD Hélène Bihan MD Jean Luc Fournier MD Jo?l Roussel MD Joseph Bénichou MD | 2006 | Obesity Surgery2006，，8： | 1 |
| 9 | Multiple Autoclave Cycles Affect the Surface of Rotary Nickel-Titanium Files An Atomic Force Microscopy Study 显示文摘 | Caroline R A Valois Luciano P Silva Richardo B Azevedo | 2008 | J Endod2008，34，： | 1 |
| 10 | A study ofknowledge management enablers across countries显示文摘 | Magnier-Watanabe R Caroline B Senoo Dai | 2011 | Knowl-edge Management Research&Practice2011，9，1： | 1 |
| 11 | Personal Resilience,Cognitive Appraisals,and Coping:An Integrative Model of Adjustment to Abortion显示文摘 | Major B R Caroline C C Cooper M L | | 0，，03： | 1 |
| 12 | Fatigue behavior of welded coverplates treated with ultrasonic impact, treatment and bolting 显示文摘 | Brain Vihauer Caroline R Bennett Adolfo B Matamoros | 2012 | Engineering Structures2012，34，： | 1 |
| 13 | Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma显示文摘 | ALEXANDRE P R CAROLINE F ERICA B | 2008 | European Journal of Pharmacology2008，580，： | 1 |
| 14 | Enhanced survival and cure of F98 glioma bearing rats following intracerebral deliveryo f carbo platin in combination with photon irradiation显示文摘 | Julia R Caroline B Rolf F | 2007 | Cancer Thera py: Preclinical Clin Cancer Res2007，13，17： | 1 |
| 15 | Fatigue Behavior of Welded Coverplates Treated with Ultrasonic Impact Treatment and Bolting 显示文摘 | VILHAUER Brian BENNETF Caroline R MATAMOROS Adolfo B | 2012 | Engineering Structures2012，34，： | 1 |
| 16 | NIR-light triggered delivery of macromolecules into the cytosol显示文摘 | Susana C R Markus O Pilar R G Carolin G Pavlov A M Sukhorukov G B Parak W J | 2012 | Journal of Controlled Release2012，159，1： | 1 |
| 17 | Understanding why women delay in seeking help for breast cancer symptoms显示文摘 | Alison B Amanda R Caroline B | 2005 | Journal of Psychosomatic Research2005，58，4： | 1 |
| 18 | Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes显示文摘Acute myeloid leukaemia(AML)patients harbouring certain chromosome abnormalities have particularly adverse prognosis.For these patients,targeted therapies have not yet made a significant clinical impact.To understand the molecular landscape of poor prognosis AML we profiled 74 patients from two different centres(in UK and Finland)at the proteomic,phosphoproteomic and drug response phenotypic levels.These data were complemented with transcriptomics analysis for 39 cases.Data integration highlighted a phosphoproteomics signature that define two biologically distinct groups of KMT2A rearranged leukaemia,which we term MLLGA and MLLGB.MLLGA presented increased DOT1L phosphorylation,HOXA gene expression,CDK1 activity and phosphorylation of proteins involved in RNA metabolism,replication and DNA damage when compared to MLLGB and no KMT2A rearranged samples.MLLGA was particularly sensitive to 15 compounds including genotoxic drugs and inhibitors of mitotic kinases and inosine-5-monosphosphate dehydrogenase(IMPDH)relative to other cases.Intermediate-risk KMT2A-MLLT3 cases were mainly represented in a third group closer to MLLGA than to MLLGB.The expression of IMPDH2 and multiple nucleolar proteins was higher in MLLGA and correlated with the response to IMPDH inhibition in KMT2A rearranged leukaemia,suggesting a role of the nucleolar activity in sensitivity to treatment.In summary,our multilayer molecular profiling of AML with poor prognosis and KMT2A-MLLT3 karyotypes identified a phosphoproteomics signature that defines two biologically and phenotypically distinct groups of KMT2A rearranged leukaemia.These data provide a rationale for the potential development of specific therapies for AML patients characterised by the MLLGA phosphoproteomics signature identified in this study. | Pedro Casado Ana Rio-Machin Juho JMiettinen Findlay Bewicke-Copley Kevin Rouault-Pierre Szilvia Krizsan Alun Parsons Vinothini Rajeeve Farideh Miraki-Moud David CTaussig Csaba Bödör John Gribben Caroline Heckman Jude Fitzgibbon Pedro R.Cutillas | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
| 19 | 地理编码方法对长期城市空气污染暴露与肺功能之间关联的影响显示文摘[背景]地址地理编码中的错误可能会影响空气污染对健康影响的估计。[目的]研究4种地理编码技术对采用小尺度(10m×10m)分散模型估计的城市空气污染与成人肺功能之间关联的影响。[方法]测量法国格勒诺布尔市354名成年居民的1秒用力呼气容积(FEV1)与用力肺活量(FVC)。这些居民参加了两个特征明确的研究:遗传和环境对哮喘影响的流行病学研究(EGEA)和欧洲共同体呼吸系统健康调查(ECRHS)。使用单个建筑物匹配作为参考方法以及三种空间插值方法编码家庭地址。使用扩散模型估计在进行肺功能测量前的12个月期间,每个参加者住址的PM10和二氧化氮的平均浓度。以个体混杂因素及同日空气污染物暴露校正暴露与肺功能参数之间的关联。对地理编码技术在地理坐标之间距离、暴露估值以及暴露估值与健康影响之间关联等方面进行比较。[结果]利用建筑物匹配和三种插值技术估计坐标之间的中位数距离分别为26.4、27.9、35.6m。相对于基于建筑匹配的暴露估值,基于三种插值技术的PM10浓度往往被高估。当使用建筑物匹配估计暴露估值时,PM10每增加一个四分位数间距(3.0μg/m3),FVC%预测值下降3.72点(95%CI:-0.56~-6.88)、FEV1%预测值下降3.86点(95%CI:-0.14~-3.24)。当使用其他地理编码方法时,关联的幅度下降[例如,使用NavTEQ预测FVC%-2.81(95%CI:-0.26,-5.35),或者使用谷歌地图预测FVC%-2.08(95%CI:-4.63~0.47,P=0.11)。[结论]研究结果表明,当使用小尺度暴露模型估算空气污染暴露时,地理编码技术的选择可能会对健康影响的评估产生影响。 | Bénédicte Jacquemin Johanna Lepeule Anne Boudier Caroline Arnould Meriem Benmerad Claire Chappaz Joane Ferran Francine Kauffmann Xavier Morelli Isabelle Pin Christophe Pison Isabelle Rios Sofia Temam Nino Künzli Rémy Slama Valérie Siroux | 2013 | 环境与职业医学2013，30，12： | 0 |
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