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| 1 | T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis显示文摘AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODS Magnetic resonance(MR) images were acquired from5 subjects scheduled for total knee arthroplasty(TKA)(mean age 70 years) and 20 young healthy control subjects without knee pain(mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained.Following TKA each condyle was divided into 4 parts(distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens(bone and cartilage blocks) were examined. For each joint,the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system.In magnetic resonance imaging(MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTS Eleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis(OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461;medial posterior condyle(MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550],suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage.Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA(P= 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients. CONCLUSION Though cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques. | Benjamin S Kester Philip M Carpenter Hon J Yu Taiki Nozaki Yasuhito Kaneko Hiroshi Yoshioka Ran Schwarzkopf | 2017 | World Journal of Orthopedics2017，8，4： | 12 |
| 2 | Factors associated with college attendance of high-school seniors显示文摘 | BORUS M E CARPENTER S A | 1984 | Economics of Education Review1984，3，3： | 1 |
| 3 | Surrogates for Resilience of Social-ecological Systems显示文摘 | Carpenter S R Westley F Turner M G | 2005 | Ecosys- tems2005，8，： | 1 |
| 4 | Psychometric evaluation of the Pittsburgh Sleep Quality Index显示文摘 | CARPENTER J S ANDRYKOWSKI M A | | 0，，01： | 1 |
| 5 | Passivated iron as core-shell nanoparticles显示文摘 | Carpenter E E Calvin S Stroud R M | 2003 | Chemica Materials2003，15，： | 1 |
| 6 | Catastrophic regime shifts in ecosystems: linking theory to observation显示文摘 | Scheffer M Carpenter S R | 2003 | Trends in Ecology & Evolution2003，18，11： | 1 |
| 7 | Mule deer body condition composition-a comparison of methods 显示文摘 | Torbit S C Carpenter L H Alldredge A W Swift D M | 1985 | J Wildl Manage1985，49，： | 1 |
| 8 | (-)-5-Methylmellein and catechol derivatives from four Semecarpus species显示文摘 | CARPENTER R C SOTHEESWARAN S SULTANBAWA M U S | 1980 | Phytochem1980，19，3： | 1 |
| 9 | Aldehyde dehydmgermse (ALDH)superfamily in plants : gene nomenclature and com- paraive genomics显示文摘 | Brocker C Vasiliou M Carpenter S | 2013 | Planta2013，237，： | 1 |
| 10 | Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture显示文摘 | CARPENTER M K INOKUMA M S | 2000 | Dev Biol2000，227，2： | 1 |
| 11 | Transformation processes in minerals 显示文摘 | Redfern S A T Carpenter M A | 2000 | Reviews in Mineralogy and Geochemistry2000，39，： | 1 |
| 12 | Powder metallurgymolybdenum : influence of powder reduction processes onproperties 显示文摘 | Tuominen S M Carpenter K H | 1980 | Journal of Metals1980，32，1： | 1 |
| 13 | Effects of Na2S and (NH4)2S edge passivation treatments on the dark current voltage characteristics of GaAs pn diodes显示文摘 | Carpenter M S Melloch M R Lundstrom M S | 1988 | Applied Physics Letters1988，52，25： | 1 |
| 14 | Catastrophic shifts in ecosystems显示文摘 | Scheffer M Carpenter S Foley J A | 2001 | Nature2001，413，6856： | 1 |
| 15 | Thrombolytic therapy for acute ischemic stroke beyond three hours显示文摘 | Carpenter C R Keim S M Milne W K | 2011 | Emerg Med2011，40，1： | 1 |
| 16 | Upper echelons research revisited:antecedents,ele-ments,and consequences of top management team corn position显示文摘 | CARPENTER M A GELETKANYCZ M A GERARD S W | | 0，，06： | 1 |
| 17 | Effects of submersed macrophytes on ecosystem processes显示文摘 | Carpenter S R Lodge D M | 1986 | Aquatic Botany1986，26，： | 1 |
| 18 | Clonally derived human embryonic stem cell lines maintain pluripotency and prolifera tive potential for prolonged periods of culture 显示文摘 | Carpenter M K Inckuma M S | 2000 | Dev Biol2000，227，2： | 1 |
| 19 | Modeling inland water quality using Landsat data显示文摘 | Carpenter D J Carpenter S M | 1983 | Remote Sensing of Environment1983，13，： | 1 |
| 20 | Catastrophic regime shifts in ecosystems: linking theory to observation显示文摘 | Scheffer M Carpenter S | 2003 | Trends in Ecology and Evolution2003，18，12： | 1 |
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