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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Induction of a virus-specific antibody response to food and month disease virus using the structural protein VP1 expressed in transgenic potato plants显示文摘 | Wigdorovitz A Trono K | 2001 | Viral Immunol2001，14，1： | 1 |
| 3 | Immunoge-nicity of the P-8 amastigote antigen in the experimental model of canine visceral leishmaniasis显示文摘 | Carrillo E Ahmed S Goldsmith-Pestana K | 2007 | Vaccine2007，25，8： | 1 |
| 4 | Robust samplingand reconstruction methods for sparse signals in the pres-ence of impulsive noise 显示文摘 | Carrillo R E Earner K E Aysal T C | 2010 | IEEE Transactions on Select-ed Topics in Signal Processing2010，4，2： | 1 |
| 5 | Body size variation among strains of the rotifers Brachionus plicatilis显示文摘 | Snell T W Carrillo K | 1984 | Aquaculture1984，73，： | 1 |
| 6 | Induction of a virus-specific antibody response to food and month disease virus using the structural protein VP1 expressed in transgenic potato plants显示文摘 | Carrillo C Wigdorovitz A Trono K | 2001 | Viral Immunol2001，14，1： | 1 |
| 7 | Induction of a virus-specific antibody response to foot-and-mouth disease virus the structural protein VP1 expressed in transgenic potato plants 显示文摘 | Wigdorovitz A Trono K | 2001 | Viral Immunol2001，14，： | 1 |
| 8 | Induction of a virus-specific antibody response to foot and mouth disease virus using the structural protein VP1 expressed in transgenic potato plants显示文摘 | Carrillo C Wigdorovitz A Trono K | 2001 | Viral Immunol2001，14，1： | 1 |
| 9 | Induction of a virus-specific antibody response to foot and mouth disease vires using the stuctural protein VP1 exprtessed in transgenic potato plants显示文摘 | Carrillo C Wigdorovitz A Trono K | 2001 | Virol Immuno12001，14，1： | 1 |
| 10 | Induction of a virusspecific antibody response to foot and mouth disease virus using the structural protein VP1 expressed in transgenic potato plants显示文摘 | Carrillo C Wigdorovitz A Trono K | 2001 | Viral Immunol2001，14，1： | 1 |
| 11 | Induction of a virus-specific antibody response to foot and mouth disease virus using the structural protein VP1 expressed in transgenic potato plants显示文摘 | Carrillo C Wigdororitz A Trono K | 2001 | Virology Immunology2001，14，1： | 1 |
| 12 | Poli- cy Strategies to Promote Eco - Innovation 显示文摘 | DEL RfO P CARRILLO - HERMOSILLA J K? NN? L? T | 2010 | Journal of Industrial Ecology2010，14，4： | 1 |
| 13 | Discovery of swine as a host for the Reston ebolavirus显示文摘 | Barrette R W Metwally S A Rowland J M Xu L Zaki S R Nichol S T Rollin P E Towner J S Shieh W J Batten B Sealy T K Carrillo C Moran K E Bracht A J Mayr G A Sirios-Cruz M Catbagan D P Lautner E A Ksiazek T G White W R McIntosh M T | 2009 | Science2009，325，5937： | 1 |
| 14 | Normal D-dimer levels do not exclude thrombotic eomplieationsin trauma patients显示文摘 | Wahl W Ahrns K Carrillo E | 2003 | Surgery2003，134，4： | 1 |
| 15 | Pilot-scale productionand liquid formulation of Rhodotorula minuta,a potential biocontrolagent of mango anthracnose显示文摘 | PATINN-VERA M JIMEONEZ B BALDERAS K ORTIZ M ALLENDE R CARRILLO A GALINDO E | 2005 | Journal of Applied Microbiology2005，99，： | 1 |
| 16 | Presynaptic activityand CaMKII modulate retrograde semaphorin signaling andsynaptic refinement显示文摘 | Carrillo R A Olsen D P Yoon K S | 2010 | Neuron2010，68，1： | 1 |
| 17 | Body size variation among strains of the rotifer Brachionus plicatilis显示文摘 | Snell T W Carrillo K | 1984 | Aquaculture1984，37，： | 1 |
| 18 | Induction of a virus specific antibody response to foot-and-mouth disease virus using the structural protein VP1 expressed in transgenic potato plants显示文摘 | CARRILLO C WIGDOROVITZ A TRORIO K | 2001 | Viral Immunol2001，14，1： | 1 |
| 19 | Tuberculous granulomas are hypoxic in Guinea pigs, rabbits, and nonhuman primates 显示文摘 | Via LE Lin PL Ray SM Carrillo J Allen SS Eum SY Taylor K Klein E Manjunatha U Gonzales J Lee EG Park SK Raleigh JA Cho SN Mcmurray DN Flynn JL Barry CE | 2008 | Infect Immun2008，76，6： | 1 |
| 20 | Approaches to characterize the degree of water repellency显示文摘 | Letey J Carrillo M L K Pang X P | 2000 | J Hydrol2000，23，： | 1 |
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