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| 1 | Not interferon, but interleukin‐6 controls early gene expression in hepatitis B virus infection显示文摘 | Marianna H?sel Maria Quasdorff Katja Wiegmann Dennis Webb Uta Zedler Mathias Broxtermann Raindy Tedjokusumo Knud Esser Silke Arzberger Carsten J. Kirschning Anja Langenkamp Christine Falk Hildegard Büning Stefan Rose‐John Ulrike Protzer | 2009 | Hepatology2009，，6： | 3 |
| 2 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 3 | Conventional therapy for Crohn's disease显示文摘Crohn 的疾病(CD ) 是未知原因的多因素的混乱。关于 CD 的病理生理学的突出的进步导致了创新治疗学的概念的开发。众多的控制试用在最后年在 CD 被执行了。然而,许多药没被规章的当局由于功效或严重副作用的缺乏同意了。因此,包括象 azathioprine 那样的 5-ASA,全身或热门的 corticosteroids,和抑制免疫力的药,著名的药仍然是 CD 治疗的支柱。重要地,象 infliximab 那样的生物制品出现了在象 fistulizing 或类固醇依赖者 CD 那样的有问题的背景有效。这评论被打算为 CD 的常规处理把实际指南给临床医生。当可得到时,我们专注于使随机化的、控制安慰剂的审判和元分析的结果,提供证据的最高的度。我们提供基于证据的处理算法每当时可能。然而,许多临床的状况没被控制临床的审判回答了,通过专家意见充满这些差距是重要的。我们希望这评论在 CD 的挑战性的处理为临床医生提供一个有用工具。 | Carsten Büning Herbert Lochs | 2006 | World Journal of Gastroenterology2006，12，30： | 2 |
| 4 | Novel rhodium complexes with ferroeene-based N-heterocylic carbenes: Synthesis, structure and catalysis显示文摘 | YU Y GERHARD R CARSTEN B | 2005 | Journal of OrganometalIic Chemistry2005，690，： | 1 |
| 5 | Interactive rendering with coherent ray tracing显示文摘 | INGO W CARSTEN B | 2001 | Computer Graphics Forum2001，20，3： | 1 |
| 6 | Identification of a domain of the baculov- irus Autographa californica multiple nucleopolyhedrovirus single strand DNA-binding protein LEF-3 essential for viral DNA replication 显示文摘 | Yu M Carstens E B | 2010 | J Virol2010，84，： | 1 |
| 7 | Aerodynamic performance analysis of a hypersonic inlet isolator using computa tion and experiment显示文摘 | Brigit U R Carsten D H Josef B | 2003 | Journal of Propulsion and Power2003，19，5： | 1 |
| 8 | Evidence for graft transmission of structural phloem proteins or their precursors in heterografts of Cucurbitaceae 显示文摘 | Goleck B Schulz A Carstens B U | 1998 | Planta1998，206，4： | 1 |
| 9 | Chromatographic analysis of endogenous retinoids in tissues and serum显示文摘 | CARSTEN K S ABRAHAM B HEINZ N | 2003 | Anal Biochem2003，315，： | 1 |
| 10 | Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2009)显示文摘 | CARSTENS E B | 2010 | Arch Virol2010，155，： | 1 |
| 11 | Listening to Mozart may not enhance performance on the revised Minnesota paper form board test 显示文摘 | CARSTENS C B HUSKINS E HOUNSHELL G W | 1995 | Psy- chol Rep1995，77，1： | 1 |
| 12 | Extragonadal germ celt tumors of the mediastinum and retroperitoneum: results from an international analysis显示文摘 | Carsten B Craig RN Jean PD | 2002 | J Clin Oncol2002，20，10： | 1 |
| 13 | Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses(2012)显示文摘 | ADAMS M J CARSTENS E B | 2012 | Arch Virol2012，157，： | 1 |
| 14 | High-throughput pro tein and DNA analysis based on microfluidic on-chip electrophoresis 显示文摘 | MEIKE K CARSTEN B TOBIAS P | 2005 | Journal of the Association for Laboratory Automation2005，10，5： | 1 |
| 15 | Preclinical activity of a new platinum analogue, lobaplatin, in cisplatin-sensitive and-resistant human testicular, ovarian, and gastric carcinoma cell lines 显示文摘 | Andreas H Carsten B Martin S | 1993 | Cancer Chemother Pharmacol1993，33，： | 1 |
| 16 | Mammary derived growth inhibitor is not a distinct protein but a mix of heart-type and adipocyte-type fatty acid-binding protein显示文摘 | BERNFRIED S NORBERT B CARSTEN H | 1994 | J Biol Chem1994，271，19： | 1 |
| 17 | Transport of insulin across rabbit nasal mucosa in vitro induced by dide- canoyl-1-α-phosphatidylcholine 显示文摘 | Carstens S Danielsen G Guldhammer B | 1993 | Diabetes1993，42，： | 1 |
| 18 | In Vivo Abdominal Magnetic Resonance Elastography for the Assessment of Portal Hypertension Before and After Transjugular Intrahepatic Portosystemic Shunt Implantation显示文摘 | Jing Guo Carsten Büning Eckart Schott Thomas Kr?ncke Jürgen Braun Ingolf Sack Christian Althoff | 2015 | Investigative Radiology2015，，： | 1 |
| 19 | Serum concentrations of antibodies against vaccine toxoids in children显示文摘 | CARSTEN H ESBEN B J FLEMMING N | | 0，，10： | 1 |
| 20 | Stability of an emittance-dominated sheet-electron beam in planar wiggler and periodic permanent magnet structures with natural focusing显示文摘 | CARSTEN B E EARLEY L M KRAWCZYK F L | 2005 | Phys Rev STAB2005，，06： | 1 |
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