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| 1 | Extraintestinal manifestations and complications in inflammatory bowel diseases显示文摘Crohn 的疾病(CD ) 和 ulcerative (UC ) 是经常包含胃肠道的除那些以外的机关的长期的煽动性的肠疾病(IBD ) 。这些非肠的爱被称为额外的肠的症状。把煽动性的肠疾病的真额外的肠的表明区分开来与第二等的额外的肠的复杂并发症,由治疗的营养不良,慢性炎或副作用引起了,可能困难。这评论在煽动性的肠疾病专注于频率,临床的演讲和额外的肠的症状的治疗学的含意。如果可能,肠的表明被区分开来与额外的肠的复杂并发症。特殊注意被给参与的更最近描述的地点;即中枢神经系统的 thromboembolic 事件,骨质疏松症,肺的参与和爱。 | Katja S Rothfuss Eduard F Stange Klaus R Herrlinger | 2006 | World Journal of Gastroenterology2006，12，30： | 26 |
| 2 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 3 | 颅内出血患者抗栓药逆转指南美国神经重症监护学会和美国重症医学会对医疗卫生专业人员的声明显示文摘背景抗栓药的使用,包括抗凝药、抗血小板药和溶栓药,在过去10年中日益增多并且预计将继续上升。虽然抗栓药相关性颅内出血可能是灾难性的,但快速逆转凝血功能障碍可能有助于限制血肿增大和改善转归。方法美国神经重症监护学会联合美国重症医学会组建了一个国际性多机构委员会,涉及的专业领域包括神经重症监护、神经内科、神经外科、卒中、血液学、血液病理学、急诊医学、药学、护理和指南制定,目的是进行文献评价并制定一份循证实践指南。该委员会进行了正式的文献检索,并对符合标准的研究进行了评价。结果利用GRADE方法学,委员会提出了在颅内出血情况下逆转维生素K拮抗药、直接Xa因子拮抗药、直接凝血酶抑制药、普通肝素、低分子肝素、类肝素、戊多糖、溶栓药和抗血小板药的推荐意见。结论该指南提供了及时和循证的抗栓药逆转策略以协助临床医生治疗抗栓药相关性颅内出血。 | Jennifer A. Frontera John J. Lewin Ⅲ Alejandro A. Rabinstein Imo P. Aisiku Anne W. Alexandrov Aaron M. Cook Gregory J. del Zoppo Monisha A. Kumar Ellinor I. B. Peerschke Michael F. Stiefel Jeanne S Teitelbaum Katja E. Wartenberg Cindy L. Zerfoss 杨一萍 谢丽丽 宁小金 季宇腾 柯开富 | 2016 | 国际脑血管病杂志2016，24，11： | 24 |
| 4 | Arctic Sea Ice and Eurasian Climate:A Review显示文摘The Arctic plays a fundamental role in the climate system and has shown significant climate change in recent decades,including the Arctic warming and decline of Arctic sea-ice extent and thickness. In contrast to the Arctic warming and reduction of Arctic sea ice, Europe, East Asia and North America have experienced anomalously cold conditions, with record snowfall during recent years. In this paper, we review current understanding of the sea-ice impacts on the Eurasian climate.Paleo, observational and modelling studies are covered to summarize several major themes, including: the variability of Arctic sea ice and its controls; the likely causes and apparent impacts of the Arctic sea-ice decline during the satellite era,as well as past and projected future impacts and trends; the links and feedback mechanisms between the Arctic sea ice and the Arctic Oscillation/North Atlantic Oscillation, the recent Eurasian cooling, winter atmospheric circulation, summer precipitation in East Asia, spring snowfall over Eurasia, East Asian winter monsoon, and midlatitude extreme weather; and the remote climate response(e.g., atmospheric circulation, air temperature) to changes in Arctic sea ice. We conclude with a brief summary and suggestions for future research. | GAO Yongqi SUN Jianqi LI Fei HE Shengping Stein SANDVEN YAN Qing ZHANG Zhongshi Katja LOHMANN Noel KEENLYSIDE Tore FUREVIK SUO Lingling | 2015 | Advances in Atmospheric Sciences2015，32，1： | 21 |
| 5 | Attractive but Toxic: Emerging Roles of Glycosidically Bound Volatiles and Glycosyltransferases Involved in Their Formation显示文摘 | Chuankui Song Katja Hartl Kate McGraphery Thomas Hoffmann Wilfried Schwab | 2018 | Molecular Plant2018，11，10： | 16 |
| 6 | Transcriptional Regulation of the Ambient Temperature Response by H2A.Z Nucleosomes and HSF1 Transcription Factors in Arabidopsis显示文摘 | Sandra Cortijo Varodom Charoensawan Anna Brestovitsky Ruth Buning Charles Ravarani Daniela Rhodes John van Noort Katja E. Jaeger Philip A. Wigge | 2017 | Molecular Plant2017，10，10： | 15 |
| 7 | 利用颜色的非刚性物体跟踪方法(英文)显示文摘提出了一个利用颜色特征实时跟踪非刚性物体的方法 .首先 ,建立了一个颜色分布模型 ,该模型对部分遮挡具鲁棒性 ,对放缩和旋转具不变性 ,且计算简单 .对非刚体物体的实时鲁棒跟踪是一个非常有挑战性的课题 ,本文提出了利用颜色特征实时跟踪非刚体物体的方法 .首先 ,建立了一个颜色分布模型 ,该模型对部分遮挡具有鲁棒性 ,对放缩具有不变性 ,而且计算简单 .然后 ,采用粒子滤波的方法将颜色分布模型集成到一个动态状态估计的概率框架中 .为了处理光照变化等引起的外貌变化 ,进一步引入自适应模型更新过程 .同时 。 | Katja Nummiaro Esther Koller-Meier Luc Van Gool | 2003 | 自动化学报2003，29，3： | 15 |
| 8 | Activins and activin antagonists in hepatocellular carcinoma显示文摘In many parts of the world hepatocellular carcinoma (HCC)is among the leading causes of cancer-related mortality but the underlying molecular pathology is still insufficiently understood.There is increasing evidence that activins,which are members of the transforming growth factorβ(TGFβ)superfamily of growth and differentiation factors,could play important roles in liver carcinogenesis.Activins are disulphide-linked homo- or heterodimers formed from four differentβsubunits termedβA,βB,βC,andβE,respectively.Activin A, the dimer of twoβA subunits,is critically involved in the regulation of cell growth,apoptosis,and tissue architecture in the liver,while the hepatic function of other activins is largely unexplored so far.Negative regulators of activin signals include antagonists in the extracellular space like the binding proteins follistatin and FLRG,and at the cell membrane antagonistic coreceptors like Cripto or BAMBI.Additionally,in the intracellular space inhibitory Smads can modulate and control activin activity.Accumulating data suggest that deregulation of activin signals contributes to pathologic conditions such as chronic inflammation,fibrosis and development of cancer.The current article reviews the alterations in components of the activin signaling pathway that have been observed in HCC and discusses their potential significance for liver tumorigenesis. | Alev Deli Emanuel Kreidl Stefan Santifaller Barbara Trotter Katja Seir Walter Berger Rolf Schulte-Hermann Chantal Rodgarkia-Dara Michael Grusch | 2008 | World Journal of Gastroenterology2008，14，11： | 8 |
| 9 | 牙列缺失患者种植体支持的固定和可摘义齿的回顾性研究显示文摘目的:研究十年观察期内种植体支持的固定和可摘义齿修复牙列缺失患者种植体的生存率和影响因素。方法:1995-2006年,227例患者(92例男性,135例女性)平均年龄63.7岁,在Charite’大学口腔颌面外科门诊接受种植和修复治疗。共1652颗种植体种植在牙列缺失上颌骨、下颌骨或双侧颌骨,支持76例(24.68%)固定义齿,232例(75.32%)可摘义齿。观察性别,种植体部位、修复方法对种植体生存率的影响。结果:其中有50例患者73颗种植体丧失,累计种植体生存率94.76%,本研究显示种植体生存率女性(93.93%)略低于男性(95.93%),但没有显著性差异。在上颌骨种植的种植体生存率(95.87%)略高于在下颌骨种植(94.53%),但统计学没有显著性意义。10年累计固定和可摘义齿的种植体生存率分别是98.02%和93.55%,两种修复方法差异有显著性。结论:确认了种植体支持牙列缺失患者修复中长期的成功率,并得出结论种植体生存率与性别,种植部位关系不大,与修复方法有关。种植体支持的固定义齿预后比可摘义齿好。 | 项立新 熊亚茸 Katja Nelson Susanne Heberer Semper Wiebke | 2010 | 口腔颌面修复学杂志2010，11，1： | 8 |
| 10 | Transmission of vector vortex beams in dispersive media显示文摘Scattering phenomena affect light propagation through any kind of medium from free space to biological tissues.Finding appropriate strategies to increase the robustness to scattering is the common requirement in developing both communication protocols and imaging systems.Recently,structured light has attracted attention due to its seeming scattering resistance in terms of transmissivity and spatial behavior.Moreover,correlation between optical polarization and orbital angular momentum(OAM),which characterizes the so-called vector vortex beams(VVBs)states,seems to allow for the preservation of the polarization pattern.We extend the analysis by investigating both the spatial features and the polarization structure of vectorial optical vortexes propagating in scattering media with different concentrations.Among the observed features,we find a sudden swift decrease in contrast ratio for Gaussian,OAM,and VVB modes for concentrations of the adopted scattering media exceeding 0.09%.Our analysis provides a more general and complete study on the propagation of structured light in dispersive and scattering media. | Ilaria Gianani Alessia Suprano Taira Giordani NicolòSpagnolo Fabio Sciarrino Dimitris Gorpas Vasilis Ntziachristos Katja Pinker Netanel Biton Judy Kupferman Shlomi Arnong | 2020 | Advanced Photonics2020，2，3： | 7 |
| 11 | 62名中国汉族青年笑线水平的测量研究显示文摘目的评估中国汉族健康人群上颌美学区域牙齿及软组织等解剖形态对容貌美观和义齿修复美学的影响,为临床牙科美学修复提供客观依据。方法对平均年龄为28.5岁的62名旅德中国汉族青年志愿者进行面部拍照记录。依据标准的试验条件对所有志愿者大笑时上颌牙齿及其牙龈和牙龈乳头进行测量分析。统计分析采用Mann—Whitney-U检验和双因子重复测量分析。结果所有志愿者在上唇大笑运动时81%的上颌中切牙至上颌前磨牙的牙龈形态均有不同程度显露。上颌中切牙平均显露高度为10mm,性别问差异无统计学意义(P〉0.05)。所有志愿者平均牙龈显露高度为1.3mm,平均显露牙龈乳头高度为3.4mm,男女间差异无统计学意义(P〉0.05)。31%(19/62)的志愿者为高笑线类型,50%(31/62)的志愿者为中度笑线类型,19%(12/62)的志愿者为低笑线类型。结论中国汉族青年人群高笑线者比例高于西方研究人群比例,其中100%汉族青年志愿者在大笑时前牙区的牙龈乳头显露。 | 胡秀莲 Susanne Heberer Katja Nelson 林野 | 2011 | 中华口腔医学杂志2011，46，11： | 7 |
| 12 | Hepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: A European perspective显示文摘 | Jerzy Jaroszewicz Beatriz Calle Serrano Karsten Wursthorn Katja Deterding Jerome Schlue Regina Raupach Robert Flisiak C.-Thomas Bock Michael P. Manns Heiner Wedemeyer Markus Cornberg | 2010 | Journal of Hepatology2010，，4： | 6 |
| 13 | European cooperation to tackle the legacies of hexachlorocyclohexane(HCH)and lindane显示文摘Hexachlorocyclohexane(HCH)waste isomers from lindane production are the largest single POPs legacy,with an estimated 4.8 to 7.4 million tonnes of disposed waste.The largest part of this waste e 1.8 to 3 million tonnes e was disposed in Europe,where most producers were located.This paper provides a short overview of projects supported by the European Union(EU)to address this waste legacy and to implement the Stockholm Convention for this group of POPs with associated protection of soil,ecosystems and human health.We report here particularly on the results of a project financed by the EU called the“HCH in EU project”,which aimed to develop a systematic inventory of sites where HCH was handled and potentially resulted in contamination.The compiled information provide guidance for competent authorities to further assess their national HCH inventory and to further develop a strategy to address this large POP legacy in future.The systematic inventory revealed that there were at least 299 sites where HCH was handled.These sites include 54 former production sites,76 pesticide processing plants that used lindane,59 uncontrolled HCH waste isomer deposits,29 landfills with HCH waste,34 former or current storage sites for stocks of obsolete pesticides including technical HCH or lindane,and 16 HCH treatment or disposal sites.Additionally,at 31 of the sites lindane/technical HCH was used in applications with significant risk of soil pollution,such as wood treatment.The number of sites in this latter category is likely higher and will need further assessment.In addition to this inventory,the“HCH in EU project”produced detailed country reports,a guidance document for how to find potentially HCHimpacted sites,and a strategy document for implementing the sustainable management of these sites EU-wide,with proposed actions at the EU,country,and site level.Furthermore,the project has facilitated information exchange and e together with other related EU projects e has led to sharing information and best practices among member states and to establishing a network of authorities and other stakeholders working on the lindane/HCH waste legacy.This collaboration will facilitate a more systematic and better coordinated process to further assess,secure,and remediate the large HCH waste legacy and reduce and control lindane/HCH releases in the EU and possibly beyond.Such a coordinated effort and exchange of information for inventorying and managing contaminated sites might also be useful for other POPs such as PFOS/PFOA or dioxins. | John Vijgen Boudewijn Fokke Guido van de Coterlet Katja Amstaetter Javier Sancho Carlo Bensaïah Roland Weber | 2022 | Emerging Contaminants2022，8，1： | 4 |
| 14 | Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-Analysis显示文摘 | Ulrike Peters Shuo Jiao Fredrick R. Schumacher Carolyn M. Hutter Aaron K. Aragaki John A. Baron Sonja I. Berndt Stéphane Bézieau Hermann Brenner Katja Butterbach Bette J. Caan Peter T. Campbell Christopher S. Carlson Graham Casey Andrew T. Chan Jenny Chan | 2012 | Gastroenterology2012，，： | 4 |
| 15 | 热电厂烟气余热回收用于集中供热的系统形式及参数分析显示文摘目前我国燃煤热电厂在能源供应中的比例占到了40%以上,却很少回收大量烟气余热,尤其以供热为目标的余热回收项目更加少见,造成了严重的环境污染和能源浪费.文中对基于直接接触式换热和吸收式热泵技术的烟气余热梯级回收利用系统建立相应的数学模型,提出一种烟气余热回收用于集中供热的方案,探究影响该系统初投资的主要参数,分析了热网回水温度对系统能效的影响及排烟温度对系统供热能力的影响.计算分析表明,当烟气入口温度为80℃时,板式换热器的冷端温差Δt_(c)从5℃降低至2℃,单位回收余热量投资费用P降低13%,表明降低Δt_(c)可降低该系统的初投资;排除外界干扰,在热电工况相同的情况下,随着回水温度由36℃降低到25℃供热等效电W由55.6 kWh/GJ降至50.6 kWh/GJ,系统的能效得到提高;当排烟温度从50℃降低至20℃,系统余热回收能力提高80%. | 王海超 刘哲毅 李骥 Esa Teppo Katja Granlund Illka Haavisto 余力 | 2021 | 东北电力大学学报2021，41，2： | 3 |
| 16 | Not interferon, but interleukin‐6 controls early gene expression in hepatitis B virus infection显示文摘 | Marianna H?sel Maria Quasdorff Katja Wiegmann Dennis Webb Uta Zedler Mathias Broxtermann Raindy Tedjokusumo Knud Esser Silke Arzberger Carsten J. Kirschning Anja Langenkamp Christine Falk Hildegard Büning Stefan Rose‐John Ulrike Protzer | 2009 | Hepatology2009，，6： | 3 |
| 17 | Neoadjuvant chemotherapy with cisplatin, 5-FU, and leucovorin (PLF) in locally advanced gastric cancer: a prospective phase II study显示文摘 | Katja Ott Andreas Sendler Karen Becker Hans-Joachim Dittler Hermann Helmberger Raimonde Busch Christian Kollmannsberger J. Rüdiger Siewert Ulrich Fink | 2003 | Gastric Cancer2003，，3： | 3 |
| 18 | Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation显示文摘 | Christine Dierks Ronak Beigi Gui-Rong Guo Katja Zirlik Mario R. Stegert Paul Manley Christopher Trussell Annette Schmitt-Graeff Klemens Landwerlin Hendrik Veelken Markus Warmuth | 2008 | Cancer Cell2008，，3： | 2 |
| 19 | Human papillomavirus infection in esophageal carcinomas: A study of 121 lesions using multiple broad-spectrum polymerase chain reactions and literature review显示文摘 | Mario Poljak Anton Cerar Katja Seme | 1998 | Human Pathology1998，，3： | 2 |
| 20 | Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells显示文摘AIM:To investigate the impact of arachidonic acid (AA) and docosahexaenoic acid (DHA) and their combination on colon cancer cell growth.METHODS:The LS-174T colon cancer cell line was used to study the role of the prostaglandin precursor AA and the omega-3 polyunsaturated fatty acid DHA on cell growth. Cell viability was assessed in XTT assays. For analysis of cell cycle and cell death,flow cytometry and DAPI staining were applied. Expression of cyclooxygenase-2 (COX-2),p21 and bcl-2 in cells incubated with AA or DHA was examined by real-time RT-PCR. Prostaglandin E2 (PGE2) generation in the presence of AA and DHA was measured using a PGE2-ELISA.RESULTS:AA increased cell growth,whereas DHAreduced viability of LS 174T cells in a time-and dose-dependent manner. Furthermore,DHA down-regulated mRNA of bcl-2 and up-regulated p21. Interestingly,DHA was able to suppress AA-induced cell proliferation and significantly lowered AA-derived PGE2 formation. DHA also down-regulated COX-2 expression. In addition to the effect on PGE2 formation,DHA directly reduced PGE2-induced cell proliferation in a dose-dependent manner. CONCLUSION:These results suggest that DHA can inhibit the pro-proliferative effect of abundant AA or PGE2. | Piet Habbel Karsten H Weylandt Katja Lichopoj Johannes Nowak Martin Purschke Jing-Dong Wang Cheng-Wei He Daniel C Baumgart Jing X Kang | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
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