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| 1 | Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection显示文摘AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis. | HMC Shantha Kumara David Gaita Hiromichi Miyagaki Xiaohong Yan Sonali AC Hearth Linda Njoh Vesna Cekic Richard L Whelan | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 4 |
| 2 | Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases显示文摘BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2 is extensively expressed during development and is upregulated at sites of tissue damage,inflammation,and in stromal cells of metastatic tumors.MMP-7 is expressed in the epithelial cells and in a variety of cancers including colon tumors.Plasma MMP-2 and MMP-7 levels were assessed before and after minimally invasive colorectal resection for cancer pathology.AIM To determine plasma MMP-2 and MMP-7 levels before and after minimally invasive colorectal resection for cancer pathology.METHODS Patients enrolled in a plasma bank for whom plasma was available were eligible.Plasma obtained from preoperative(Preop)and postoperative blood samples was used.Only colorectal cancer(CRC)patients who underwent elective minimally invasive cancer resection with preop,post-operative day(POD)1,3 and at least 1 late postop sample(POD 7-34)were included.Late samples were bundled into 7 d blocks(POD 7-13,14-20,etc.)and treated as single time points.Plasma MMP-2 and MMP-7 levels were determined via enzyme-linked immunosorbent assay in duplicate.RESULTS Total 88 minimally invasive CRC resection CRC patients were studied(right colectomy,37%;sigmoid,24%;and LAR/AR 18%).Cancer stages were:1,31%;2,30%;3,34%;and 4,5%.Mean Preop MMP-2 plasma level(ng/mL)was 179.3±40.9(n=88).Elevated mean levels were noted on POD1(214.3±51.2,n=87,P<0.001),POD3(258.0±63.9,n=80,P<0.001),POD7-13(229.9±62.3,n=65,P<0.001),POD 14-20(234.9±47.5,n=25,P<0.001),POD 21-27(237.0±63.5,n=17,P<0.001,)and POD 28-34(255.4±59.7,n=15,P<0.001).Mean Preop MMP-7 level was 3.9±1.9(n=88).No significant differences were noted on POD 1 or 3,however,significantly elevated levels were noted on POD 7-13(5.7±2.5,n=65,P<0.001),POD 14-20(5.9±2.5,n=25,P<0.001),POD 21-27(6.1±3.6,n=17,P=0.002)and on POD 28-34(6.8±3.3,n=15 P<0.001,)vs preop levels.CONCLUSION MMP-2 levels are elevated for 5 wk and MMP-7 levels elevated for weeks 2-6.The etiology of these changes in unclear,trauma and wound healing likely play a role.These changes may promote residual tumor growth and metastasis. | HMC Shantha Kumara Hiromichi Miyagaki Sajith A Herath Erica Pettke Xiaohong Yan Vesna Cekic Richard L Whelan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 3 | A comparison of three different intravitreal treatment modalities of macular edema due to branch retinal vein occlusion 显示文摘 | Cekic O Cakir M Yazici AT | 2010 | Curr Eye Res2010，35，： | 1 |
| 4 | Influence of the prepa- ration procedure and chitosan type on physicochemical prop- erties and release behavior of alginate-chitosan microparti- cles显示文摘 | Cekic ND Milic JR Savic SD | 2009 | Drug Devlnd Pharm2009，35，9： | 1 |
| 5 | Oncologic Colorectal Resection, Not Advanced Endoscopic Polypectomy, Is the Best Treatment for Large Dysplastic Adenomas显示文摘 | Joon Ho Jang Emre Balik Daniel Kirchoff Wouter Tromp Anjali Kumar Michael Grieco Daniel L. Feingold Vesna Cekic Linda Njoh Richard L. Whelan | 2012 | Journal of Gastrointestinal Surgery2012，，1： | 1 |
| 6 | Pars plana vitrectomy in the treatment of phakic and pseudophakic malignant glaucoma 显示文摘 | Cekic o Batman C | 1998 | Arch Ophthalmol1998，116，1： | 1 |
| 7 | Management of traumatic retinal detachment with vitreon in children显示文摘 | Cekic O Batman C Totan Y Aslan O Ozalp S | 1999 | Int Ophthalmol1999，23，3： | 1 |
| 8 | Spectrophotometric determination of paracetamol in urine with tetrahydroxycalix arene as acoupling reagent and preconcentration with triton X-114 using cloud point extraction 显示文摘 | Filik H Sener I Cekic S D | 2006 | Chemical & Pharmaceutical Bulletin2006，54，6： | 1 |
| 9 | Age effects on gray matter volume and attentional performance in Zen meditation显示文摘 | Giuseppe Pagnoni Milos Cekic | | Neurobiology of Aging0，，： | 1 |
| 10 | Physiological and chemical changes during harvest maturity in apple cultivars显示文摘 | Gercekcioglu R Cekic C Filiz A | 2004 | Asian J Chem2004，16，34： | 1 |
| 11 | Spectrophotometric determination of paracetamol in urine with tetrahydroxycalixarene as a coupling reagent and preconcentration with Triton X-114 using cloud point extraction显示文摘 | Filik H Sener I Cekic S D | 2006 | Chem Pharm Bull2006，54，6： | 1 |
| 12 | Determination of pollen- quantity, pollen viability and pollen germination in some dogrose species(Rosa section Caninae) 显示文摘 | Gunes M Cekic C Edizer Y | 2005 | Acta Horti-culturae2005，690，： | 1 |
| 13 | Vitrectomy with silicone oil or long-acting gas in eyes with giant retinal tears : long-term follow-up of a randomized clinical trial显示文摘 | BATMAN C CEKIC O | 1999 | Retina1999，19，3： | 1 |
| 14 | Lenticular calcium,magnesium,and iron levels in diabetic rats and verapamil effect显示文摘 | Cekic O Bardak Y | | 0，，02： | 1 |
| 15 | Combined phacoemulsification, vitrectomy, foreign-body extraction, and intraocular lens implantation 显示文摘 | Batman C Cekic O Totan Y | 2000 | J Cataract Refract Surg2000，26，2： | 1 |
| 16 | The vaccine adjuvant monophosphoryl lipid A as a TRIF -biased agonist of TLR4 显示文摘 | Mata - Haro V Cekic C Martin M | 2007 | Science2007，316，5831： | 1 |
| 17 | Effects of humidified and dry air on corneal endothehal cells during vitreal fluid-air exchange 显示文摘 | CEKIC O OHJI M HAYASHI A | 2002 | Am J Ophthalmol2002，134，1： | 1 |
| 18 | Progesterone and its metabolite allopregnanolone differentially regulate hemostatic proteins after traumatic brain injury 显示文摘 | VanLandingham J W Cekic M Cutler S M | 2008 | J Cereb Blood Flow Metab2008，28，11： | 1 |
| 19 | Small incision extracapsular cataract surgery with manual phacotrisection 显示文摘 | Hepsen IF Cekic O Bayramlar H Totan Y | 2000 | J Cataract Refract Surg2000，26，7： | 1 |
| 20 | Vitrectomy with silicone oil or long-acting gas in eyes with giant retinal tears:long-term follow up of a randomized clinical trial显示文摘 | BATMAN C CEKIC O | 1999 | Retina1999，19，3： | 1 |
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