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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Use of a Dispersed Iron Catalys for Upgrading Extra-Heavy Crude Oil Using Methane as Source of Hydrogen显示文摘 | Cesar O Eduardo F Alfredo M | 2003 | Fuel2003，82，： | 1 |
| 3 | Structural change of bitumen in the recycling process by using rhe- ology and NMR显示文摘 | LUIGI F LUIGI G CESARE O R | 2012 | Ind Eng Chem Res2012，51，16： | 1 |
| 4 | The IL-23/Th17 Axisin the Immunopathogenesis of Psoriasis显示文摘 | Cesare A D Meglio P D Nestle F O | 2009 | J Invest Dermatol2009，129，6： | 1 |
| 5 | Inhibition of angiotensin converting enzyme activity by flavanol-rich foods显示文摘 | Lucas A G Javier I O Cesar G F | 2006 | Journal of Agricultural and Food Chemistry2006，54，1： | 1 |
| 6 | A role for Th17 ceils in the immunopathogenesis of atopic dermatitis7 显示文摘 | DI CESARE A DI MEGLIO P NESTLE F O | 2008 | J Invest Dermatol2008，128，11： | 1 |
| 7 | FT-IR and EPR spectro-scopic analysis of LaI _xCexCo03 perovskite-like catalysts for NO reduction by CO 显示文摘 | Lucio F Cesare O Tommy B | 1997 | Applied Catalysis B: Environmental1997，13，： | 1 |
| 8 | Changes in anthocyanin concentration in lychee (litchi chinensis sonn) pericarp during maturation 显示文摘 | Javier R L Cesar O F Pedro W E | 1999 | Food Chemistry1999，65，： | 1 |
| 9 | Changes in anthocyanin concentration in lychee ( litchi chinensis sonn ) pericarp during maturation 显示文摘 | Javier R L Cesar O F Pedro W E | 1999 | Food Chem1999，65，： | 1 |
| 10 | The IL-23/Th17axis in the immuno pathogenesis of psoriasis显示文摘 | DI CESARE A DI MEGLIO P NESTLE F O | 2009 | J Invest Dermatol2009，129，： | 1 |
| 11 | Changes in anthocyanin concentration in lychee(litchi chinensis sonn)pericarp during maturation显示文摘 | JAVIER R L CESAR O F PEDRO W E | 1999 | Food chemistry1999，65，： | 1 |
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