|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 3 | Antenna-assisted picosecond control of nanoscale phase transition in vanadium dioxide显示文摘Nanoscale devices in which the interaction with light can be configured using external control signals hold great interest for next-generation optoelectronic circuits.Materials exhibiting a structural or electronic phase transition offer a large modulation contrast with multi-level optical switching and memory functionalities.In addition,plasmonic nanoantennas can provide an efficient enhancement mechanism for both the optically induced excitation and the readout of materials strategically positioned in their local environment.Here,we demonstrate picosecond all-optical switching of the local phase transition in plasmonic antenna-vanadium dioxide(VO_(2))hybrids,exploiting strong resonant field enhancement and selective optical pumping in plasmonic hotspots.Polarization-and wavelength-dependent pump–probe spectroscopy of multifrequency crossed antenna arrays shows that nanoscale optical switching in plasmonic hotspots does not affect neighboring antennas placed within 100 nm of the excited antennas.The antenna-assisted pumping mechanism is confirmed by numerical model calculations of the resonant,antenna-mediated local heating on a picosecond time scale.The hybrid,nanoscale excitation mechanism results in 20 times reduced switching energies and 5 times faster recovery times than a VO_(2) film without antennas,enabling fully reversible switching at over two million cycles per second and at local switching energies in the picojoule range.The hybrid solution of antennas and VO_(2) provides a conceptual framework to merge the field localization and phase-transition response,enabling precise,nanoscale optical memory functionalities. | Otto L Muskens Luca Bergamini Yudong Wang Jeffrey M Gaskell Nerea Zabala CH de Groot David W Sheel Javier Aizpurua | 2016 | Light(Science & Applications)2016，5，1： | 5 |
| 4 | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells显示文摘 | Hsu, TL Hanson, SR Kishikawa, K Wang, SK Sawa, M Wong, CH | 2007 | 中国生物学文摘2007，21，10： | 5 |
| 5 | Gallstone ileus:One-stage surgery in a patient with intermittent obstruction显示文摘Gallstone ileus, an uncommon complication of cholelithiasis, is described as a mechanical intestinal obstruction due to impaction of one or more large gallstones within the gastrointestinal tract. The clinical presentation is variable, depending on the site of obstruction, manifested as acute, intermittent or chronic episodes. A 51-year-old female patient was referred to our hospital with 3 events of intestinal obstruction during the previous 7 d. At admission, there were clinical signs of intestinal obstruction; abdominal film demonstrated dilated bowel loops, air-fluid levels and a vague image of a stone in the inferior left quadrant. Once stabilized, a laparotomy was performed. Surgical findings were distention of the jejunum and ileum proximal to a palpable stone in the ileum as well as gallstones and a cholecystoduodenal fistula in the gallbladder. An enterolithotomy, repair of the cholecystoduodenal fistula and cholecystectomy were performed. The postoperative course was uneventful. There is no uniform surgical procedure for this disease. When the patient is too ill or when biliary surgery is not advisable, an enterolithotomy is the best option. The one-stage procedure should be the offered to adequately stabilized patients when local and general conditions, such as good cardiorespiratory and metabolic reserve permit a more prolonged surgical procedure. | Carlos M Nuo-Guzmán José Arróniz-Jáuregui Pável A Moreno-Pérez édgar A Chávez-Solís Nereida Esparza-Arias Cuauhtémoc I Hernández-González | 2010 | World Journal of Gastrointestinal Surgery2010，2，5： | 5 |
| 6 | 巨噬细胞中缺氧诱导因子1α表达促进动脉粥样硬化的发展显示文摘粥样硬化病变包含缺氧区域,但缺氧病理生理的重要性未知。缺氧诱导因子1a(hypoxia-induciblefactor-1α,HIF-1α)是细胞对低氧反应的关键转录因子。研究人员对HIF-1α在巨噬细胞促进小鼠动脉粥样硬化的生物学效应方面进行调查和验证。 | 刘莉 叶鹏 Aarup A Pedersen TX Junker N Christoffersen C Bartels ED Madsen M Nielsen CH Nielsen LB | 2016 | 中华高血压杂志2016，24，9： | 3 |
| 7 | Endocrine hypertension:An overview on the current etiopathogenesis and management options显示文摘Endocrine causes of secondary hypertension include primary aldosteronism,pheochromocytoma,cushing's syndrome,hyperparathyroidism and hypo-and hyperthyroidism.They comprise 5%-10% of the causes of secondary hypertension.Primary hyperaldosteronism,the most common of the endocrine cause of hypertension often presents with resistant or difficult to control hypertension associated with either normo-or hypokalemia.Pheochromocytoma,a great mimicker of many conditions,is associated with high morbidity and mortality if left untreated.A complete history including pertinent family history,physical examination along with a high index of suspicion with focused biochemical and radiological evaluation is important to diagnose and effectively treat these conditions.The cost effective targeted genetic screening for current known mutations associated with pheochromocytoma are important for early diagnosis and management in family members.The current review focuses on the most recent evidence regarding causes,clinical features,methods of diagnosis,and management of these conditions.A multidisciplinary approach involving internists,endocrinologists and surgeons is recommended in optimal management of these conditions. | Reena M Thomas Ewa Ruel Prapimporn Ch Shantavasinkul Leonor Corsino | 2015 | World Journal of Hypertension2015，5，2： | 2 |
| 8 | 越南胡志明市及周边地区大学汉语教学情况调查与对策研究显示文摘本文采用实地考察、数据统计分析等方法对胡志明市及周边地区有汉语教学的5所大学的具体情况进行了调查,调查总人数为364人。结果显示:目前越南大学汉语培养的类型主要有汉语语言专业与非汉语语言专业两类,招生条件日趋灵活,招生数量呈逐年上升的趋势;学生方面,汉语学习的动机主要是为工作服务,学习态度与策略需要改善与协助;教师方面,博士学位教师及外籍教师资源少,有的学校甚至没有;教材方面,由于一些客观原因未能及时更新,教材及参考书籍缺乏。针对目前的汉语教学现状,本文提出以下对策:组织丰富、有效的活动,以帮助学生改善学习态度和策略;通过更多的渠道营造语言环境;越南本土教师积极参加编写具有针对性、统一性的教材;携手创办汉语书架,以丰富汉语参考资料。 | 王玲娟 黄美英 chí cám mùi | 2017 | 重庆师范大学学报(哲学社会科学版)2017，0，1： | 2 |
| 9 | 体位性低血压的危险因素:老年男女存在差异显示文摘体位性低血压(orthostatic hypotension,OH)一般发生在站立后调节血压水平的机制发生变化以后。目前尚不清楚不同性别间OH的发生率和危险因素有何不同。本文旨在调查老年人OH患病率和危险因素的性别差异。方法:纳入来自委内瑞拉马拉开波老龄化研究的882名参与者。从仰卧位到站立位3 min后,收缩压持续下降≥20和(或)舒张压持续下降≥10 mm Hg(1 mm Hg=0.133 kPa)定义为OH。考虑到性别的交互作用和性别分层,研究者采用多因素Logistic回归模型评估男、女OH危险因素的相关性。 | Méndez AS Melgarejo JD Mena LJ Chávez CA González AC Boggia J Terwilliger JD Lee JH Maestre GE 陈云 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 10 | Direct detection of angioinvasive pulmonary aspergillosis in immunosuppressed patients: preliminary results with high-resolution 16-MDCT angiography显示文摘 | Sonnet S Buitrago-Tellez CH Tamm M | 2005 | AJR2005，185，3： | 1 |
| 11 | A survey of Web Information Extraction Systems显示文摘 | Chang CH Kayed M Girgis MR | 2006 | IEEE Transactions on Knowledge and Data Engineering2006，18，10： | 1 |
| 12 | Markers of tumor angiogenesis and tumor cells in bone marrow in gastric cancer patients 显示文摘 | Gretschel S Astrosini Ch Vieth M | 2008 | Eur J Surg Oncol2008，34，： | 1 |
| 13 | Croeetin inhibits leukocyte adherence to vascular endothelial cells induced by AGEs 显示文摘 | Xiang M Qian ZY Zhou CH | 2006 | J Ethnopharmaeol2006，107，1： | 1 |
| 14 | ICF core sets:how to specify impairment and function in systemic Lupus erythematosus显示文摘 | Aringer M Stamm TA Pisetsky DS Yarboro CH Cieza A Smolen JS | 2006 | Lupus2006，15，： | 1 |
| 15 | Determination of fra- grance allergens in cosmetics by size - exclusion chromatography fol- lowed by gas chromatography - mass spectrometry显示文摘 | NIEDERER M BOLLHALDER R HOHL CH | 2006 | Journal of Chro- matography A2006，1132，1： | 1 |
| 16 | Real-time imaging of trapping and ureasedependent transmigration of Cryptococcus neoformans in mouse brain显示文摘 | Shi M Li SS Zheng C Jones GJ Kim KS Zhou H Kubes P Mody CH | 2010 | J Clin Invest2010，120，5： | 1 |
| 17 | Retinal neovascularization w ith myelinated nerve fibers显示文摘 | Sellami D Bouacida W Maalej A Ben-Amor S Chabouni M Kamoun B | 2008 | J Fr Ophthalmol2008，31，1： | 1 |
| 18 | A new automatedmethod for rat sleep deprivation with minimal confounding effectson corticosterone and locomotor activity显示文摘 | Leenaars CH Dematteis M Joosten RN | 2011 | J Neurosci Meth-ods2011，196，： | 1 |
| 19 | Duloxetine: A new treatment for the emotional and physical symptoms of depression 显示文摘 | Mallinckrodt CH Golddtein D J Detke M J | 2003 | Prin Care Companion J Clin Psychiatry2003，5，1： | 1 |
| 20 | The groningen valve voice prothesis in sheffield: a 4-year review显示文摘 | Parker AJ Ch M | 1992 | The Journal of Laryngology and Otology1992，106，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员