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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | An- timitotic properties of resveratrol analog (z) - 3, 5,4 ' - trimethoxystilbene 显示文摘 | Chabert P Fougerousse A Brouillard R | 2006 | BioFactors2006，27，： | 1 |
| 3 | An Evaluation of stresses and deflection of spur gear teeth under strain显示文摘 | T Dang Tran R Mathis | 1974 | ASME Journal of Engineering for Industry1974，96，2： | 1 |
| 4 | Results of Non-operative Therapy for Delayed Hemorrhage after Pancreaticoduodenectomy显示文摘 | Laura Beyer Rémi Bonmardion Sandrine Marciano Olivier Hartung Olivier Ramis Léna?k Chabert Marc Léone Olivier Emungania Pierre Orsoni Marc Barthet Stéphane V. Berdah Christian Brunet Vincent Moutardier | 2009 | Journal of Gastrointestinal Surgery2009，，5： | 1 |
| 5 | An evaluation of stresses and deflection of spur gear teeth under strain显示文摘 | Chabert C Dang Tran T Mathis R | 1974 | ASME Journal of Engineering for Industry1974，，： | 1 |
| 6 | Anti-mitotic properties of resveratrol analog ( Z )-3, 5, 4'- trimethoxystilbene 显示文摘 | Chabert P Fougerousse A Brouillard R | 2006 | Biofactors2006，27，： | 1 |
| 7 | An evaluation of stresses and deflection of spur gear teeth under strain显示文摘 | Chabert G Tran T D Mathis R | 1974 | ASME Journal Engineering for Industry1974，，： | 1 |
| 8 | Electrophysiological evidencefor the presence of NMDA receptors in the guinea pig cochlea显示文摘 | Puel JL Ladrech S Chabert R | 1991 | Hear Res1991，51，2： | 1 |
| 9 | Anti mitotic properties of resveratrol analog (Z) -3, 5, 4' trimethoxystilbene 显示文摘 | Chabert P Fougerousse A Brouillard R | 2006 | Biofactors2006，27，14： | 1 |
| 10 | An evaluation of stresses and deflection of spur gear teeth under strain显示文摘 | G Chabert T T Dang R Mathis | 1974 | ASME Journal of Engineering for Industry1974，96，1： | 1 |
| 11 | An evaluation of stresses and deflection of spur gear teeth under strain 显示文摘 | Chabert G DangTran T Mathis R | 1974 | ASME Journal of Engineering for Industry1974，，： | 1 |
| 12 | Hilbert versus Concordia transform for three-phase machine stator current time-frequency monitoring显示文摘 | Baptiste Trajin Marie Chabert Jérémi Regnier Jean Faucher | 2009 | Mechanical Systems and Signal Processing2009，，8： | 1 |
| 13 | An evaluation of stresses and deflection of spur gear teeth under strain显示文摘 | CHABERT G DANG TRAN T MATHIS R | 1974 | ASME Journal of Engineering for Industry1974，96，1： | 1 |
| 14 | An evaluation of stresses and deflection of spur gear teeth under strain 显示文摘 | Chabert G Dang Tran T Mathis R | 1974 | ASME Journal of Engineering for Industry1974，96，1： | 1 |
| 15 | An evaluation ofstresses and deflection of spur gear teeth under strain显示文摘 | Chabert G Dang Tran T Mathis R | 1974 | ASME Journal of Engineering for Industry1974，2，： | 1 |
| 16 | An evaluation of stresses and deflec- tion of spur gear teeth-under strain显示文摘 | Chabert G Dang T T Mathis R | 1974 | ASME Journal of Engineering for Industry1974，96，1： | 1 |
| 17 | Estimation of the degree of polarization for hybrid/compact and linear dual- pol SAR intensity images principles and applications显示文摘 | Shirvany R Chabert M and Tourneret J | 2013 | IEEE Transactions on Geoscience and Remote Sensing2013，51，1： | 1 |
| 18 | Ship and oil-spill detection using the degree of polarization in linear and hybrid/compact dual-pol SAR显示文摘 | Shirvany R Chabert M and Tourneret J | 2012 | IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing2012，5，3： | 1 |
| 19 | The 20210A allele of the prothrombin gene is an independent risk factor for per- ception deafness in patients with venous thromboembolic antecedents显示文摘 | Mercier E Quere I Chabert R | 1999 | Blood1999，93，9： | 1 |
| 20 | Double lumen tube intubation systematic verification with fiberoptic bronchoscopy : between what who should do and what we can do显示文摘 | Gaillat F Duponq R Chabert L | 2011 | Eur J Cardiothorac Surg2011，40，4： | 1 |
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