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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | DNA polymorphism haplotypes of the human apolipoprotein APOA1 - APOC3-APOA4 gene cluster显示文摘 | Antonarakis SE Oettgen P Chakravarti A | 1988 | Hum Genet1988，80，3： | 1 |
| 3 | Oral hydrogesterone versus in travaginal micronised progesterone as luteal phase support in assisted reproductive technology(ART) cycles:Results of a randomised study显示文摘 | Chakravarty B N Shirazee H H Dam P | 2005 | J Steroid Biochem Mol Biol2005，97，5： | 1 |
| 4 | Analysis of nonlinear blood flow in a stenosed flexible artery显示文摘 | Chakravarty S Datta A Mandal P K | 1995 | Int J Engng Sci1995，33，12： | 1 |
| 5 | Parti- tioned presentation of multicomponent bundle prices: evalua- tion, choice and underlying processing effects显示文摘 | Chakravarti D Krish R Paul P et A1 | 2002 | Journal of Consumer Psychology2002，12，3： | 1 |
| 6 | Differential influence of ectomycorrhizae on plant growth and disease resistance in Pinus sylvestris seedlings显示文摘 | Chakravarty P Unestam T | 1987 | Journal of Phytopathology1987，120，2： | 1 |
| 7 | A nonlinear tow-Dimensional model of blood flow in an overlapping arterial stenosis subjected to body acceleration显示文摘 | Chakravarty S Mandal P K | 1996 | Math Comput Modelling1996，24，1： | 1 |
| 8 | Forest Depend ence and Income Distribution in a Subsistence Economy Evidence from India显示文摘 | REDDY S R C CHAKRAVARTY S P | 1999 | World development1999，45，： | 1 |
| 9 | J Med Chem显示文摘 | Chakravarty P K Carlp L Weber M J | 1983 | 26:6331983，26，： | 1 |
| 10 | Zinc in human maligancies显示文摘 | Chakravarty P K Ghosh A Chowdhury J R et al | 1986 | Neoplasma1986，33，1： | 1 |
| 11 | Integrated control of Fusarium damping-off in conifer seedlings显示文摘 | Chakravarty P Khasa D Dancik B | 1999 | Journal of Plant Disease and Protection1999，106，4： | 1 |
| 12 | Interleukin-6 as a therapeutic target in human ovarian cancer 显示文摘 | Coward J Kulbe H Chakravarty P | 2011 | Clin Cancer Res2011，17，： | 1 |
| 13 | Rabbit arterial thromobosis production by systemic procedures显示文摘 | Constantinides P Chakravarti RN | 1961 | Arch Pathol1961，72，8： | 1 |
| 14 | Oral dydrogesterone versus intravaginal micronised progesterone as luteal phase support in assisted reproductive technology(ART)cycles:results of a randomized study显示文摘 | Chakravarty BN Shirazee HH Dam P | 2005 | J Steroid Biochem Mol Biol2005，97，： | 1 |
| 15 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 16 | Prolactin and heregulin override DNA damage-induced growth arrest and promote phosphatidylinositol-3 kinase-dependent proliferation in breast cancer cells 显示文摘 | Chakravarti P Henry M K Quelle F W | 2005 | Int J Oncol2005，26，2： | 1 |
| 17 | Adenovirus-mediated antisense ATM gene transfer sensitizes prostate cancer cells to radiation显示文摘 | Fan Z Chakravarty P Alfieri A | 2000 | Cancer Gene Ther2000，7，10： | 1 |
| 18 | Synthesis,crystal structures and properties of temary copper (Ⅱ) complexes having 2,2'-bipyridine and α-amino acid salicylaldininates as models for the type-2 sites in copper oxidases显示文摘 | REDDY P NETHAJI M CHAKRAVARTY A R | 2002 | Inorganica Chimica Acta2002，337，： | 1 |
| 19 | Oral dydrogesterone versus intravaginal micronised progesterone as iuteal phase support in assisted reproductive technology (ART) cyclea results of a randomised study显示文摘 | Chakravarty BN Shirazee HH Dam P | 2005 | J Steroid Biochem Mol Biol2005，97，5： | 1 |
| 20 | A new finite element model for welding heat sources显示文摘 | Goldak J A Chakravarti A P Bibby M | 1984 | Metallurgical Transactions1984，，15： | 1 |
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