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| 1 | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings显示文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. | LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 2 | Origin and therapy for hypertriglyceridaemia in type 2 diabetes显示文摘Hypertriglyceridaemia(HTG) is a risk factor for cardiovascular disease(CVD) in type 2 diabetes and is caused by the interaction of genes and non-genetic factors, specifically poor glycaemic control and obesity. In spite of statin treatment, residual risk of CVD remains high in type 2 diabetes, and this may relate to HTG and atherogenic dyslipidemia. Treatment of HTG emphasises correcting secondary factors and adverse lifestyles, in particular, diet and exercise. Pharmacotherapy is also required in most type 2 diabetic patients. Statins are the first-line therapy to achieve recommended therapeutic targets of plasma low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol. Fibrates, ezetimibe and n-3 fatty acids are adjunctive treatment options for residual and persistent HTG. Evidence for the use of niacin has been challenged by non-significant CVD outcomes in two recent large clinical trials. Further investigation is required to clarify the use of incretin-based therapies for HTG in type 2 diabetes. Extreme HTG, with risk of pancreatitis, may require insulin infusion therapy or apheresis.New therapies targeting HTG in diabetes need to be tested in clinical endpoint trials. The purpose of this review is to examine the current evidence and provide practical guidance on the management of HTG in type 2 diabetes. | Jing Pang Dick C Chan Gerald F Watts | 2014 | World Journal of Diabetes2014，5，2： | 2 |
| 3 | Private key generation from on-line handwritten signatures 显示文摘 | Hao F Chan C W | 2002 | Information Management & Computer Security2002，10，2： | 1 |
| 4 | Surface characterization in ultra-precision machining of Al/SiC metal matrix composites using data dependent systems analysis显示文摘 | CHEUNG C F CHAN K C LEE W B | 2003 | Journal of Materials Processing Technology2003，140，： | 1 |
| 5 | Deposition behaviour and morphology of Ni-SiC electro-composites under triangular waveform 显示文摘 | Hu F Chan K C | 2004 | Appl Surf Sci2004，243，： | 1 |
| 6 | Minimally invasive plate osteosynthesis in the treatment of proximal humeral fracture 显示文摘 | Lau T W Leung F Chan C F | 2007 | Int Orthop2007，31，5： | 1 |
| 7 | 显示文摘 | Ng S C Ma Y F Chan H S O | 1999 | Synth Met1999，100，： | 1 |
| 8 | Effect of spinel content on hot strength of alumina-spinel castables in the temperature range 1 000~1 500 ℃显示文摘 | Ko Y C Chan C F | 1999 | Journal of the European Ceramic Society1999，19，15： | 1 |
| 9 | Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism 显示文摘 | Chan D C Watts G F Ng T W | 2005 | Clin Chem2005，51，： | 1 |
| 10 | Radiation dose reduction in pediatric cranial CT显示文摘 | Chan C Y Wang Y C Chau L F et ol | 1999 | Pediatr Radiol1999，29，10： | 1 |
| 11 | What is the optimal clinl- cal technique for measurement of left ventricular volume after my- ocardlal infarction? A comparative study of 3-dimensional echo- cardiography, single photon emission computed tomography, and cardiac magnetic resonance imaging显示文摘 | Chan J Jenkins C Khafagi F etal | 2006 | J Am Soc Echocardio- gr2006，19，2： | 1 |
| 12 | Accurate distributed range-based positioning algorithm for wireless sensor networks 显示文摘 | CHAN F K W SO H C | 2009 | IEEE Transactions on Signal Processing2009，57，10： | 1 |
| 13 | An Empirical Comparison of Ahemative Models of the Short Term Interest Rate 显示文摘 | CHAN K C KAROLYI G A LONGSTAFF F A SANDERS A B | 1992 | Journal of Finance1992，47，3： | 1 |
| 14 | On the runup of long waves on a plane beach显示文摘 | CHAN I C LIU P L F | 2012 | Journal of Geophysical Research2012，117，8： | 1 |
| 15 | Plasma treatments of indium tin oxide anodes in carbon tetrafluorinde( CF4 )/oxygen( 02 )to im- prove the performance of organic light-emitting diodes显示文摘 | CHAN I M HONG F C | 2003 | Thin Solid Films2003，444，： | 1 |
| 16 | Electrocodeposition behavior of Ni-SiC composite under different shaped waveforms显示文摘 | Hu F Chan K C | 2004 | Appl Surf Sci2004，233，： | 1 |
| 17 | The impact of the 9-21 earthquake experiences of Taiwanese nurses as rescuers显示文摘 | Shih F J Liao Y C Chan S M | 2002 | Social Science Medicine2002，55，： | 1 |
| 18 | An Empirical Comparison of Alternative Models of the Short-Term Interest Rate 显示文摘 | Chan K C Karolyi G A Longstaff F A Sanders A B | 1992 | The Journal of Finance1992，47，3： | 1 |
| 19 | A fast solver for Fredholm equations of the second kind with weakly singular kernels显示文摘 | CHAN R LIN F R CHAN C F | 2002 | J Numerical Mathematics2002，10，： | 1 |
| 20 | Undergraduate Medical Education:Comparison of Problem-based Learning and Conventional Teaching显示文摘 | Nandi P L Chan J N F Chan C P K | 2000 | HKMJ2000，6，3： | 1 |
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