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| 1 | 香港华人妇女产后抑郁危险因素的前瞻性研究显示文摘目的:产后抑郁是一种常见的精神障碍,对产妇、新生儿和其它家庭成员导致广泛的伤害。产后抑郁的病因学研究大多是基于西方样本,对其中的社会文化原因也缺乏实证研究。本研究从人口学、心理社会及种族文化因素等方面探讨中国妇女产后抑郁症状学的决定因素。方法:在大学附属综合医院产前门诊连续收集登记的中国孕妇959例,从她们第一次产前检查开始评估(基线),以后分别在孕期的最后3个月、产后即刻和产后3个月时评估。调查涉及的危险因素分6个方面:人口学和社会经济背景,躯体疾病及精神疾病病史, 产前抑郁情绪,围生期应激源,人际关系,和种族文化环境。采用等级回归进行分析。因变量是产后3个月时的抑郁评分。结果:决定产后抑郁症状学的因素有:目前的生活事件,缺乏社会支持,婚姻不满意,既往有故意自伤史,以及产前存在抑郁情绪。婆媳关系不好和没有陪月在产后阶段也与抑郁评分高有关联。结论:西方研究所确立的产后抑郁危险因素大体适用于中国妇女。产褥期的社会文化特点同样对产妇情绪有影响。 | Dominic TS Lee Alexander SK Yip Sandra SM Chan Fiona FY Lee Tony YS Leung Tony KH Chung | 2005 | 中国心理卫生杂志2005，19，9： | 50 |
| 2 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 3 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 4 | Synergistic effect of osmotic and oxidative stress in slow-developing cataract formation显示文摘 | Chan AW Ho YS Chung SK | 2008 | Exp Eye Res2008，87，5： | 1 |
| 5 | Determining the influence of biocompatible oxygenators during cardiopulmonary bypass by 99m Te-DTPA aerosol assessment of pulmonary permeability 显示文摘 | Dixon KL Agrawal SK Chan KM | 2002 | Nucl Med Commun2002，23，3： | 1 |
| 6 | Determinants of Tc-99m sestamibi SPECT scan sensitivity in primary hyperparathyroidism显示文摘 | Swanson TW Chan SK Jones SJ | 2010 | Am J Surg2010，199，5： | 1 |
| 7 | Community nursing services for postdischarge chronically显示文摘 | Chow SK Wang FK Chan TM | 2008 | J ClinNurs2008，17，7： | 1 |
| 8 | Inhibition of cell proliferation and the action mechanisms of arsenic trioxide (As2O3) on human breast cancer cells显示文摘 | CHOW SK CHAN JY FUNG KP | 2004 | J Cell Biochem2004，93，1： | 1 |
| 9 | Outbreaks of enterovirus 71 infection显示文摘 | AbuBakar S Chan YF Lain SK | | 0，，05： | 1 |
| 10 | Evalualion of a nurse-led diseasemanagement programmer for chronic kidney disease: a randomizedcontrolled trial显示文摘 | Wong Fk Chou SK Chan TW | 2010 | Int J Nurs Stud2010，47，3： | 1 |
| 11 | Promoter methylation of E-cadherin gene in gastric mucosa associated with helicobacter pylori infection and in gastric cancer显示文摘 | Chan AO Lam SK Wong BC | 2005 | Gut2005，52，4： | 1 |
| 12 | Helical CT imaging of clinically suspected appendicitis:correlation of CT and histological findi ngs显示文摘 | Wong SK Chan LP | 2002 | Clin Radiol2002，57，8： | 1 |
| 13 | Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 ( FHL1 ) 显示文摘 | Lee SM Tsui SK Chan KK | 1998 | Gene1998，216，： | 1 |
| 14 | Evaluation of a nurse-led disease management programme for chronic kidney disease: a randomized controlled trial 显示文摘 | Wong FK Chow SK Chan TM | 2010 | Int J Nurs Stud2010，47，3： | 1 |
| 15 | Comparison of effects between home visits with telephone calls and telephone calls only for transitional discharge support: A randomised controlled trial显示文摘 | Wong FK Chow SK Chan TM | 2014 | Age Ageing2014，43，1： | 1 |
| 16 | The development of the Chinese version of impact of event scale - revised (CIES-R) 显示文摘 | Wu KK Chan SK | 2003 | Social Psychiatry and Psychiatric Epidemiology2003，38，2： | 1 |
| 17 | Effect of Helicobacter pylori eradication on oasophageal acid exposure in patients with reflux esophagitis显示文摘 | Wu JC Chan FK Wong SK | 2002 | Aliment Pharmaeol Ther2002，16，3： | 1 |
| 18 | Molecular cloning and characterization of FHI2, a novel LIM domain protein preferentially expressed in human heart显示文摘 | Chan KK Tsui SK Lee SM | 1998 | Gene1998，210，： | 1 |
| 19 | Keratin expression in breast cancers显示文摘 | Shao MM Chan SK Yu AM | | 0，，03： | 1 |
| 20 | Early prediction of tumor recurrence after curative resection of gastric carci-noma by measuring soluble E-cadherin显示文摘 | Chan AO Chu KM Lam SK | 2005 | Cancer2005，104，4： | 1 |
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