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您的检索式：作者名="Chanchan Gao"
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| 1 | Understanding the spatial representativeness of air quality monitoring network and its application to PM_(2.5)in the China's Mainland显示文摘Air pollution has seriously endangered human health and the natural ecosystem during the last decades.Air quality monitoring stations(AQMS)have played a critical role in providing valuable data sets for recording regional air pollutants.The spatial representativeness of AQMS is a critical parameter when choosing the location of stations and assessing effects on the population to long-term exposure to air pollution.In this paper,we proposed a methodological framework for assessing the spatial representativeness of the regional air quality monitoring network and applied it to ground-based PM_(2.5)observation in the mainland of China.Weighted multidimensional Euclidean distance between each pixel and the stations was used to determine the representativeness of the existing monitoring network.In addition,the K-means clustering method was adopted to improve the spatial representativeness of the existing AQMS.The results showed that there were obvious differences among the representative area of 1820 stations in the mainland of China.The monitoring stations could well represent the PM_(2.5)spatial distribution of the entire region,and the effectively represented area(i.e.the area where the Euclidean distance between the pixels and the stations was lower than the average value)accounted for 67.32%of the total area and covered 93.12%of the population.Forty additional stations were identified in the Northwest,North China,and Northeast regions,which could improve the spatial representativeness by 14.31%. | Ling Su Chanchan Gao Xiaoli Ren Fengying Zhang Shanshan Cao Shiqing Zhang Tida Chen Mengqing Liu Bingchuan Ni Min Liu | 2022 | Geoscience Frontiers2022，13，3： | 3 |
| 2 | High intratumoral expression of elF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer显示文摘Gastric cancer is an important health problem,being the fifth most common cancer and the third leading cause of cancer-related death worldwide.Aberrant protein translation contributes to the oncogenesis and development of cancers,and upregulation of translation initiation factor elF4A1 has been observed in several kinds of malignancies.However,the role of elF4A1 in gastric cancer progression remains unclear.In this study,we found that the expression of elF4A1,a component of translation initiation complex,was increased in gastric cancer.High expression of elF4A1 was positively associated with poor tumor differentiation,late T stage,lymph node metastasis,advanced TNM stage,and poor prognosis in patients with gastric cancer.Overexpression of elF4A1 promoted the migration and invasion of gastric cancer cells in vitro and enhanced tumor metastasis in nude mice model.Mechanism studies revealed that elF4A1 induced epithelial-to-mesenchymal transition(EMT)of gastric cancer cells through driving the translation of SNAI1 mRNA.Together,these findings indicate that elF4A1 promotes EMT and metastasis of gastric cancer and suggest that elF4A1 is a potential target for the adjuvant therapy for gastric cancer patients. | Chanchan Gao Xinyin Guo Anwei Xue Yuanyuan Ruan Hongshan Wang Xiaodong Gao | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 1 |
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