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356篇 您的检索式：作者名="Chandra A K"

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	题名	作者	年代	出处	被引量
1	Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs.	Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash	2011	World Journal of Gastroenterology2011，17，3：	2
2	A new control approach to three-phase active power filter for harmonics and reactive power eompensation显示文摘	Singh B Al-Haddad K Chandra A	1998	IEEE Transactions on Power Systems1998，13，1：	1
3	System-on-a-Chip test data compression and decompression architectures based on Golomb codes 显示文摘	Chandra A Chakrabarty K	2001	IEEE Transactions on CAD of Integrated Circuits and System2001，20，3：	1
4	Spec-trum Challenges and Solutions by Cognitive Radio: anOverview 显示文摘	SRIDHARA K CHANDRA A TRIPATHI P S M	2008	Wireless Personal Communications2008，45，3：	1
5	Wear behaviour of AE42+20% Saffil Mg-MMC显示文摘	MONDAL A K CHANDRA RAO B S S KUMAR S	2007	Tribology International2007，40，：	1
6	A review of active power filters for power quality improvement 显示文摘	SINGH B AL-HADDAD K CHANDRA A	1999	IEEE Trans Ind Electron1999，46，5：	1
7	Wear behaviour of AE42+20% saffil Mg-MMC显示文摘	MONDAL A K CHANDRA RAO B S S KUMAR S	2007	Tribology International2007，40，2：	1
8	Electrical and magnetic properties of Mn-Ni-Zn ferrites processed by citrate precursor method显示文摘	SINGH A K VERMA A THAKUR O P CHANDRA PRAKASH GOEL T C MENDIRATTA R G	2003	Materials Letters2003，57，56：	1
9	System-on-a- chip test data compression and decompression architectures based on Golomb codes显示文摘	CHANDRA A CHAKRABARTY K	2001	IEEE Trans Comp Aid Des2001，20，3：	1
10	Thermo-dynamic equilibrium analysis of ring opening of decalin 显示文摘	Govindhakannan J Chandra Mouli K Phoenix A	2012	Fu-el2012，97，40：	1
11	System-on-a-chip test data compression and decompression architectures based on Golomb codes显示文摘	Chandra A Chakrabarty K	2001	IEEE Transactions on CAD of Integrated Circuits and System2001，20，3：	1
12	Nair,clinical,diagnostic,and management perspectives of aortic dissection显示文摘	Ijaz A K Chandra K	2002	Chest2002，122，1：	1
13	Active power filter for harmonic and reactive power compensation in three-phase, four-wire systems supplying non-linear loads显示文摘	S1NGH B AL-HADDAD K CHANDRA A	1998	ETEP1998，8，2：	1
14	Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘	Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O		0，，：	1
15	Fertility of men and women aged 15 44 years in the United States: National Survey of Family Growth, 2006-2010显示文摘	Martinez G Daniels K Chandra A	2012	Natl Health Stat Report2012，12，51：	1
16	A generalized self-consistent mechanics method for microcracked solids显示文摘	HUANG Y HU K CHANDRA A	1994	Journal of the Mechanics and Physics of Solids1994，42，8：	1
17	System-on-a-Chip test data compression and decompression architectures based on Golomb codes显示文摘	Chandra A Chakrabarty K	2001	IEEE Transactions on CAD of Integrated Circuits and Systems2001，20，3：	1
18	A small world network of prime numbers显示文摘	Chandra A K Dasgupta S	2006	Physica A:Statistical Mechanics and its Applications2006，357，34：	1
19	Test data compression and test resource partitioning for system-on-a-chip using Frequency- Directed Run-length(FDR) codes显示文摘	Chandra A Chakrabarty K	2003	IEEE Trans on Comput- ers2003，52，8：	1
20	Di-etary calcium induced cytological and biochemicalchanges in thyroid显示文摘	CHANDRA A K GOSWAMI H SENGUPTA P	2012	Environmental Toxicology andPharmacology2012，34，2：	1

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