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| 1 | The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase显示文摘Suicide genes have recently emerged as an attractive alternative therapy for the treatment of various types of intractable cancers.The efficacy of suicide gene therapy relies on efficient gene delivery to target tissues and the localized concentration of final geneproducts. | Chang DY Yoo SW Hong Y Kim S Kim SJ Yoon SH Cho KG Paek SH Lee YD Kim SS Suh-Kim H | 2010 | 中国神经肿瘤杂志2010，8，2： | 3 |
| 2 | Identification of SNP-containing regulatory motifs in the myelodysplastic syndromes model using SNP arrays and gene expression arrays显示文摘Myelodysplastic syndromes have increased in frequency and incidence in the American population, but patient prognosis has not significantly improved over the last decade. Such improvements could be realized if biomarkers for accurate diagnosis and prognostic stratification were successfully identified. In this study, we propose a method that associates two state-of-the-art array technologies-single nucleotide polymorphism (SNP) array and gene expression array-with gene motifs considered transcription factor -binding sites (TFBS). We are particularly interested in SNP-containing motifs introduced by genetic variation and mutation as TFBS. The potential regulation of SNP-containing motifs affects only when certain mutations occur. These motifs can be identified from a group of co-expressed genes with copy number variation. Then, we used a sliding window to identify motif candidates near SNPs on gene sequences. The candidates were filtered by coarse thresholding and fine statistical testing. Using the regression-based LARS-EN algorithm and a level-wise sequence combination procedure, we identified 28 SNP-containing motifs as candidate TFBS. We confirmed 21 of the 28 motifs with ChIP-chip fragments in the TRANSFAC database. Another six motifs were validated by TRANSFAC via searching binding fragments on coregulated genes. The identified motifs and their location genes can be considered potential biomarkers for myelodysplastic syndromes. Thus, our proposed method, a novel strategy for associating two data categories, is capable of integrating information from different sources to identify reliable candidate regulatory SNP-containing motifs introduced by genetic variation and mutation. | Jing Fan Jennifer G. Dy Chung-Che Chang Xiaobo Zhou | 2013 | Chinese Journal of Cancer2013，32，4： | 2 |
| 3 | Carcinoid tumours of the thymus显示文摘 | Wang DY Chang DB Kuo SH | 1994 | Thorax1994，49，4： | 1 |
| 4 | Amiodarone versus procainamide for the acute treatment of recurrent supraventricular tachycardia in pediatric patients 显示文摘 | Chang PM Silka MJ Moromisato DY | 2010 | Circ Arrhythm Electrophysiol2010，3，2： | 1 |
| 5 | Endoscopic surgery for spontaneous basal ganglia hemorrhage: comparing endoscopic surgery, stereotactic aspiration, and craniotomy in non- comatose patients 显示文摘 | Cho DY Chen CC Chang CS | 2006 | Surg Neurol2006，65，6： | 1 |
| 6 | CT,MR,US,18F-FDGPET/CT,and their combined use for the assessment of cervical lymph node metastases in squamous cell carcinoma of the head and neck显示文摘 | Yoon DY Hwang HS Chang SK | 2009 | Eur Radiol2009，19，： | 1 |
| 7 | The prevalence and significance of incidental thyroid nodules identified on computed tomography显示文摘 | Yoon DY Chang SK Choi CS | 2009 | J Comput Asiist Tomogr2009，2，5： | 1 |
| 8 | Development of muhiplex real - time reverse transcriptase PCR assays for detecting eight medically important flaviviruses in mosquitoes 显示文摘 | Chao DY Davis BS Chang GJ | 2007 | J Clin Microbiol2007，45，2： | 1 |
| 9 | Use of three-dimensionalultrasonography in the evaluation of uterine perfusion and healingafter laparoscopic myomectomy显示文摘 | Chang WC Chang DY Huang SC | 2009 | Fertility and Sterility2009，92，3： | 1 |
| 10 | Efficacy and safety of the use of titanium mesh cages and anterior cervical plates for interbody fusion after anterior cervical corpectomy显示文摘 | Chuang HC Cho DY Chang CS | 2006 | Surg Neurol2006，65，5： | 1 |
| 11 | CsBi4Te6:A high-performance thermoelectric material for low-temperature applications显示文摘 | Chang DY Hogan T Brazis P | 2000 | Science2000，287，5455： | 1 |
| 12 | Endoscopic surgery for spontaneous basal ganglia hemorrhage: comparing endoscopic surgery, stereotactic aspiration, and craniotomy in noncomatose patients 显示文摘 | Cho DY Chen CC Chang CS | 2006 | Surg Neurol2006，65，6： | 1 |
| 13 | Accuracy of CT angiography in the assessment of the circle of Willis: comparison of volume- rendered images and digital subtraction angiography 显示文摘 | Han A Yoon DY Chang SK | 2011 | Acta Radiol2011，52，： | 1 |
| 14 | Use of three-dimensional ultrasonography in the evaluation of uterine perfusion and healing after laparoscopic myomectomy显示文摘 | Chang WC Chang DY Huang SC | 2009 | Fertil Steril2009，92，3： | 1 |
| 15 | Quantitative evaluation of altered hepatic spaces and membrane transport in flbrofie rat liver显示文摘 | Hung DY Chang P Cheung K | 2002 | Hepatolegy2002，36，5： | 1 |
| 16 | Identification of the gene for vitamin K epoxide reductase显示文摘 | Li T Chang CY Jin DY | 2004 | Nature2004，427，5： | 1 |
| 17 | GATA-1 mediates autoregulation of Gfi-1B transcription in K562 cells Nucleic Acids Res显示文摘 | Huang DY Kuo YY Chang ZF | 2005 | 33(16):5331-53422005，33，16： | 1 |
| 18 | Operating time and blood loss during laparoscopic-assisted vaginal hysterectomy with in situ morcellation显示文摘 | Chou LY Sheu BC Chang DY | 2011 | Acta Obstet Gynecol Scand2011，90，9： | 1 |
| 19 | Comparison of multifidus muscle atrophy and trunk extension muscle strength: percutaneous versus open pedicle screw fixation 显示文摘 | Kim DY Lee SH Chang SK | 2005 | Spine2005，30，1： | 1 |
| 20 | Quantitative evaluation of altered hepatic spaces and membrane transport in fibrotic rat liver 显示文摘 | Hung DY Chang P Roberts MS | 2002 | Hepatology2002，36，5： | 1 |
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