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| 1 | dentification of testosterone-/androgen receptor-regulated genes in mouse Sertoli cells显示文摘雄激素和雄激素受体(AR ) 在男精子发生和富饶起重要作用,在 Sertoli 房间的还详细的 androgen/AR 信号仍然保持不清楚。为了识别 AR,在 Sertoli 房间指向基因,我们分析了在在 Sertoli 房间缺乏 AR 的老鼠之间的睾丸的基因表示侧面(S-AR −/y) 和他们的同窝出生的人野类型(WT ) 老鼠。数字基因表达式分析与 WT 相比在 S-AR −/y 鼠标睾丸识别了 2276 基因 downregulated 和 2865 基因 upregulated。到在在 Sertoli 房间以内的差别下面的进一步的钉子,我们首先构造了 Sertoli 房间线 TM4 与稳定地 transfected AR (作为 TM4/AR 说出) 并且发现雄激素在 Sertoli TM4 和 TM4/AR 房间没有通过到 transactivate AR。有趣地, AR-cDNA 的另外的短暂 transfection 与比 TM4 房间显示出更多的雄激素敏感 10 次的 TM4/AR 房间导致了重要雄激素应答。处于最大的雄激素反应被表明的条件,我们然后分析了基因表示并且发现 2313 基因的表示层次被改变多于由 AR-cDNA 的短暂 transfection 双重面对睾丸激素。在这些基因之中,包括 164 upregulated 和 439 downregulated, 603 androgen-/AR-regulated 基因在两个 S-AR −/y 老鼠睾丸和 TM4/AR 房间被发现。用信息科学分析,基因本体论被使用分析这些 androgen-/AR-regulated 基因在精子发生的过程预言 androgen/AR 的潜在的角色。一起,用在两只 S-AR −/y 老鼠的基因分析,睾丸和 TM4/AR 房间可以帮助我们更好在精子发生在 Sertoli 房间和他们的影响理解 androgen/AR 信号。 | Qiao-Xia Zhang Xiao-Yan Zhang Zhen-Ming Zhang Wei Lu Ling Liu Gang Li Zhi-Ming Cai Yao-Ting Gui Chawnshang Chang | 2012 | Asian Journal of Andrology2012，14，2： | 9 |
| 2 | Dynamics of Rodent and Rodent-borne Disease during Construction of the Three Gorges Reservoir from 1997 to 2012显示文摘Objective To investigate the impact of impoundment and active public health interventions on rodent populations and rodent-borne diseases in the Three Gorges reservoir region from 1997 to 2012. Methods Surveillance data from 1997 to 2012 were extracted from the Public Health Surveillance System of The Three Gorges established in 1997. Temporal changes in the incidences of hemorrhagic fever with renal syndrome(HFRS) and leptospirosis, rodent density, pathogen-carrying rates, and their correlations were analyzed. Results The average indoor and outdoor rodent densities decreased overall from 1997 to 2012. The average densities decreased by 47.72%(from 4.38% to 2.29%) and 39.68%(from 4.41% to 2.66%), respectively, after impoundment(2003-2012) compared with before impoundment(1997-2002). The average annual incidence rates of HFRS and leptospirosis were 0.29/100,000 and 0.52/100,000, respectively, and decreased by 85.74%(from 0.68/100,000 to 0.10/100,000) and 95.73%(from 1.47/100,000 to 0.065/100,000), respectively, after impoundment compared with before impoundment. Incidences of HFRS and leptospirosis appear to be positively correlated with rodent density in the reservoir area. Conclusion This study demonstrated that rodent density and incidences of rodent-borne diseases decreased and were maintained at low levels during construction of the Three Gorges dam. Measures that reduce rodent population densities could be effective in controlling rodent-borne diseases during large-scale hydraulic engineering construction. | CHANG Zhao Rui LU Liang MAO De Qiang PAN Hui Ming FENG Lian Gui YANG Xiao Bing LIU Feng Feng HE Yuan Yuan ZHANG Jing YANG Wei Zhong | 2016 | Biomedical and Environmental Sciences2016，29，3： | 5 |
| 3 | Synthesis and properties of tribranched chromophores with triazine and fluorene units显示文摘二 tribranched 色基,是的 1,3,5-triazine 电子缺乏的核心,结合了桥牌的 9,9-dimethylfluorene, diphenylamino (4a ) 和象捐赠电子的结束组的 naphthylamino (4b ) ,成功地经由联合反应的 BuchwaldHartwig 被准备。他们的线性 photophysical 和二光子的吸收(TPA ) 性质被吸收,荧光和非线性的传播方法分别地调查。色基的吸收 cut-offs 在 550 nm 下面,两色基有强壮的荧光排放。复合 4a (206.3 美国通用汽车公司) 在 800 nm 在 femtosecond 政体比 4b (57.8 美国通用汽车公司) 展出更大的 TPA 剖面图。 | Li Liu Zhi Qiang Zhou Jie Ping Shi Chang Gui Lu Yi Ping Cui Guo Yuan Lu | 2011 | Chinese Chemical Letters2011，22，10： | 1 |
| 4 | Two-photon Absorption and Optical Power Limiting Properties of Two Novel Dibenzothiophene-based Chromophores显示文摘Two novel V-shaped symmetric chromophores: E-2,8-bis(4-vinyl-4-carbazol-9-yl)diben- zothiophene (abbreviated as SK-G1) and E-2,8-bis(4-vinyl-4-triphenylamino) dibenzothiophene (abbreviated as ST-G1) have been synthesized and characterized. Their two photon absorption properties were measured by the open-aperture femtosecond Z-scan technique and the nanosecond nonlinear optical transmission (NLT), respectively, when pumped by Ti: sapphire laser at 750 nm and 800 nm. | Jian Wei CHENG Xiao Mei WANG Jin XU Chang Gui LU Yi Ping CUI Bo LI Shi Xiong QIAN Ping YANG | 2006 | Chinese Chemical Letters2006，17，9： | 1 |
| 5 | Prevalence of High Non-high-density Lipoprotein Cholesterol and Associated Risk Factors in Patients with Diabetes Mellitus in Jilin Province,China:A Cross-sectional Study显示文摘Dyslipidemia is a risk factor for cardiovascular diseases(CVDs)in patients with diabetes,and non-high-density lipoprotein cholesterol(non-HDL-C)is a better predictor of CVDs than low-density lipoprotein cholesterol(LDL-C)in patients with diabetes.Therefore,we aimed to investigate the distribution of non-HDL-C and the prevalence of high non-HDL-C level in Chinese patients with diabetes mellitus and identify | HE Huan ZHEN Qing LI Yong KOU Chang Gui TAO Yu Chun WANG Chang Joseph Sam Kanu LU Yu Ping YU Ming Xi ZHANG Hui Ping YU Ya Qin LI Bo LIU Ya Wen | 2016 | Biomedical and Environmental Sciences2016，29，7： | 1 |
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