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| 1 | Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest显示文摘蛋白质说出 NVP (1 ) 从巢 vespae 被孤立。T 他现在的学习的目的是阐明 NVP (1 ) 是否并且怎么调制 HepG2 房间的增长。在 6.6 μg/ml 的集中的 NVP (1 ) 能在阶段 G 1 逮捕房间周期并且禁止 cyclinB, cyclinD1 和 cyclinE 的 mRNA 表示。NVP (1 ) 压制了 cdk2 蛋白质表示,但是增加了 p27 和 p21 蛋白质表示。然而, NVP (1 ) 没改变 p16 蛋白质表示层次。NVP (1 ) 在由原子染色质冷凝作用显示了的 HepG2 房间支持了 apoptosis,并且另外,表明小径的细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 被激活。而且,当 HepG2 房间是有英皇家空军之阶级最低之兵禁止者 PD98059 的 pretreated 时,津贴蛋白质表示水平被稀释。这些结果证明 NVP (1 ) 通过表明小径的英皇家空军之阶级最低之兵禁止 HepG2 的增长。NVP (1 ) 能是为肝癌症的潜在的药。 | Changdong Wang Peng Chen Hongjuan Jin Xu Yan Lu Gan Yi Li Shiyi Zhou Junli Chang Yuesheng Wang Guangxiao Yang Guangyuan He | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 11 |
| 2 | Experimental study on seismic behavior of circular RC columns strengthened with pre-stressed FRP strips显示文摘Bonding fiber reinforced polymer(FRP)has been commonly used to improve the seismic behavior of circular reinforced concrete(RC)columns in engineering practice.However,FRP jackets have a significant stress hysteresis effect in this strengthening method,and pre-tensioning the FRP can overcome this problem.This paper presents test results of25 circular RC columns strengthened with pre-stressed FRP strips under low cyclic loading.The pre-stressing of the FRP strips,types of FRP strips and longitudinal reinforcement,axial load ratio,pre-damage degree and surface treatments of the specimens are considered as the primary factors in the tests.According to the failure modes and hysteresis curves of the specimens,these factors are analyzed to investigate their effect on bearing capacity,ductility,hysteretic behavior,energy dissipation capacity and other important seismic behaviors.The results show that the initial lateral confined stress provided by pre-stressed FRP strips can effectively inhibit the emergence and development of diagonal shear cracks,and change the failure modes of specimens from brittle shear failure to bending or bending-shear failure with better ductility.As a result,the bearing capacity,ductility,energy dissipation capacity and deformation capacity of the strengthened specimens are all significantly improved. | Zhou Changdong Lu Xilin Li Hui Tian Teng | 2013 | Earthquake Engineering and Engineering Vibration2013，12，4： | 1 |
| 3 | Effect of Nerve-Sparing Radical Hysterectomy on Bladder Function Recovery and Quality of Life in Patients With Cervical Carcinoma显示文摘 | Jiahan Wu Xishi Liu Keqin Hua Changdong Hu Xiaojun Chen Xin Lu | 2010 | International Journal of Gynecological Cancer2010，，5： | 1 |
| 4 | An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC) has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional samples using Sanger sequencing. Whole-genome SNP arrays were employed to detect copy number alteration(CNA) and loss of heterozygosity(LOH) in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations(NSSMs) in102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology(GO) analysis. Tumor genomes with TP53 mutations were significantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B(30.9%), amplification of 11q13.3 covering CCND1(30.9%), and TP53 point mutation(50.9%) occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC.Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p11.2, and 3p12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes.These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting. | Qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 1 |
| 5 | Fine ash formation during pulverized coal combustion-- a comparison of O2/CO2 combustion versus cir combustion显示文摘 | Sheng Changdong Lu Yuhong Gao Xiangpeng | 2007 | Energy &Fuels2007，21，2： | 1 |
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