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| 1 | The distribution rule and seepage effect of the fractures in the ultra-low permeability sandstone reservoir in east Gansu Province,Ordos Basin显示文摘To study the impact of the fractures on development in the ultra-low permeability sandstone reservoir of the Yangchang Formation of the Upper Triassic in the Ordos Basin,data on outcrops,cores,slices,well logging and experiments are utilized to analyze the cause of the formation of the fractures,their distribution rules and the control factors and discuss the seepage flow effect of the fractures. In the studied area developed chiefly high-angle tectonic fractures and horizontal bedding fractures,inter-granular fractures and grain boundary fractures as well. Grain boundary fractures and intragranular fractures serve as vital channels linking intragranular pores and intergranular solution pores in the reservoir matrix,thus providing a good connectivity between the pores in the ultra-low perme-ability sandstone reservoir. The formation of fractures and their distribution are influenced by such external and internal factors as the palaeo-tectonic stress field,the reservoir lithological character,the thickness of the rock layer and the anisotropy of a layer. The present-day stress field influences the preservative state of fractures and their seepage flow effect. Under the tec-tonic effect of both the Yanshan and Himalayan periods,in this region four sets of fractures are distributed,respectively assuming the NE-SW,NW-SE,nearly E-W and nearly S-N orientations,but,due to the effect of the rock anisotropy of the rock formation,in some part of it two groups of nearly orthogonal fractures are chiefly distributed. Under the effect of the present-day stress field,the fractures that assume the NE-SW direction have a good connectivity,big apertures,a high permeability and a minimum starting pressure,all of which are main advantages of the seepage fractures in this region. With the development of oilfields,the permeability of the fractures of dif-ferent directions will have a dynamic change. | ZENG LianBo1,GAO ChunYu2,QI JiaFu1,WANG YongKang2,LI Liang2 & QU XueFeng2 1 State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing 102249,China 2 Changqing Oilfield Branch,PetroChina,Xi’an 163517,China | 2008 | Science China Earth Sciences2008，51，S2： | 22 |
| 2 | Involvement of CsWRKY70 in salicylic acid-induced citrus fruit resistance against Penicillium digitatum显示文摘Penicillium digitatum causes serious losses in postharvest citrus fruit.Exogenous salicylic acid(SA)can induce fruit resistance against various pathogens,but the mechanism remains unclear.Herein,a transcriptome-based approach was used to investigate the underlying mechanism of SA-induced citrus fruit resistance against P.digitatum.We found that CsWRKY70 and genes related to methyl salicylate(MeSA)biosynthesis(salicylate carboxymethyltransferase,SAMT)were induced by exogenous SA.Moreover,significant MeSA accumulation was detected in the SA-treated citrus fruit.The potential involvement of CsWRKY70 in regulating CsSAMT expression in citrus fruit was studied.Subcellular localization,dual luciferase,and electrophoretic mobility shift assays and an analysis of transient expression in fruit peel revealed that the nucleus‐localized transcriptional activator CsWRKY70 can activate the CsSAMT promoter by recognizing the W-box element.Taken together,the findings from this study offer new insights into the transcriptional regulatory mechanism of exogenous SA-induced disease resistance in Citrus sinensis fruit. | Bing Deng Wenjun Wang Changqing Ruan Lili Deng Shixiang Yao Kaifang Zeng | 2020 | Horticulture Research2020，7，1： | 6 |
| 3 | Overview of HBV whole genome data in public repositories and the Chinese HBV reference sequences显示文摘The number of Hepatitis B virus (HBV) whole genomic sequences in public nucleotide databases (GenBank, EMBL, and DDBJ) had reached 866 by January 1, 2007. Coming from 46 countries and regions, these sequences were categorized as eight genotypes (A–H). With the statistical and phylogenetic analysis on all available complete genomic data of HBV, we here present an overview of HBV sequences in public databases. From all registered 229 HBV genomes in Chinese regions as well as 59 sequencing data from our research group, we report the establishment of reference sequences of HBV strains prevailing in China. These analyses provide clues for the effects of HBV genotypes in host clinical progressions, geographic distribution of the infection, and the viral evolutionary history. Moreover, the viral sequence reference would be helpful in the identiffcation of various HBV mutations. Based on the analysis of various public databases, we suggest that the Chinese HBV database with the clinical information should be constructed. | Guanghua Wu Huiguo Ding Changqing Zeng | 2008 | Progress in Natural Science:Materials International2008，18，1： | 5 |
| 4 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 5 | HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site显示文摘Hepatitis B virus(HBV),one of the well-known DNA oncogenic viruses,is the leading cause of hepatocellular carcinoma(HCC).In infected hepatocytes,HBV DNA can be integrated into the host genome through an insertional mutagenesis process inducing tumorigenesis.Dissection of the genomic features surrounding integration sites will deepen our understanding of mechanisms underlying integration.Moreover,the quantity and biological activity of integration sites may reflect the DNA damage within affected cells or the potential survival benefits they may confer.The wellknown human genomic features include repeat elements,particular regions(such as telomeres),and frequently interrupted genes(e.g.,telomerase reverse transcriptase[i.e.TERT],lysine methyltransferase 2B[i.e.KMT2B],cyclin E1[CCNE1],and cyclin A2[CCNA2]).Consequently,distinct genomic features within diverse integrations differentiate their biological functions.Meanwhile,accumulating evidence has shown that viral proteins produced by integrants may cause cell damage even after the suppression of HBV replication.The integration-derived gene products can also serve as tumor markers,promoting the development of novel therapeutic strategies for HCC.Viral integrants can be single copy or multiple copies of different fragments with complicated rearrangement,which warrants elucidation of the whole viral integrant arrangement in future studies.All of these considerations underlie an urgent need to develop novel methodology and technology for sequence characterization and function evaluation of integration events in chronic hepatitis B-associated disease progression by monitoring both host genomic features and viral integrants.This endeavor may also serve as a promising solution for evaluating the risk of tumorigenesis and as a companion diagnostic for designing therapeutic strategies targeting integration-related disease complications. | Dake Zhang Ke Zhang Urlike Protzer Changqing Zeng | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 4 |
| 6 | Scanning for signatures of geographically restricted selection based on population genomics analysis显示文摘Natural selection, as the driving force of human evolution, has direct impact on population differentiation. However, it is still unclear to what extent the genetic differentiation has been caused by natural selection. To explore this question, we performed a genome-wide scan with single nucleotide polymorphism (SNP) data from the International HapMap Project. Single locus FST analysis was applied to assess the frequency difference among populations in autosomes. Based on the empirical distribution of FST, we identified 12669 SNPs correlating to population differentiation and 1853 candidate genes subjected to geographic restricted natural selection. Further interpretation of gene ontogeny revealed 121 categories of biological process with the enrichments of candidate genes. Our results suggest that natural selection may play an important role in human population differentiation. In addition, our analysis provides new clues as well as research methods for our understanding of population differentiation and natural selection. | DENG LiBin TANG XiaoLi KANG Jian WANG QingYun ZENG ChangQing | 2007 | Chinese Science Bulletin2007，52，19： | 3 |
| 7 | MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways显示文摘 | Longlong Bao Yan Yan Can Xu Weidan Ji Shuwen Shen Gaoya Xu Yong Zeng Bin Sun Haihua Qian Lei Chen Mengchao Wu Changqing Su Jie Chen | 2013 | Cancer Letters2013，，2： | 3 |
| 8 | Joint Algorithm of Message Fragmentation and No-Wait Scheduling for Time-Sensitive Networks显示文摘Time-sensitive networks(TSNs)support not only traditional best-effort communications but also deterministic communications,which send each packet at a deterministic time so that the data transmissions of networked control systems can be precisely scheduled to guarantee hard real-time constraints.No-wait scheduling is suitable for such TSNs and generates the schedules of deterministic communications with the minimal network resources so that all of the remaining resources can be used to improve the throughput of best-effort communications.However,due to inappropriate message fragmentation,the realtime performance of no-wait scheduling algorithms is reduced.Therefore,in this paper,joint algorithms of message fragmentation and no-wait scheduling are proposed.First,a specification for the joint problem based on optimization modulo theories is proposed so that off-the-shelf solvers can be used to find optimal solutions.Second,to improve the scalability of our algorithm,the worst-case delay of messages is analyzed,and then,based on the analysis,a heuristic algorithm is proposed to construct low-delay schedules.Finally,we conduct extensive test cases to evaluate our proposed algorithms.The evaluation results indicate that,compared to existing algorithms,the proposed joint algorithm improves schedulability by up to 50%. | Xi Jin Changqing Xia Nan Guan Peng Zeng | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，2： | 3 |
| 9 | Primary hypertrophic osteoarthropathy:an update显示文摘Digital clubbing,which has been recognized as a sign of systemic disease,is one of the most ancient diseases.However,the pathogenesis of clubbing and hypertrophic osteoarthropathy has hitherto been poorly understood.The study of a clinically indistinguishable idiopathic form(primary hypertrophic osteoarthropathy,PHO)provides an opportunity to understand the pathogenesis of hypertrophic osteoarthropathy.Current advances in the study of PHO are discussed.The impaired metabolism of prostaglandin E2(PGE2)plays a central role in its pathogenesis. | Zeng Zhang Changqing Zhang Zhenlin Zhang | 2013 | Frontiers of Medicine2013，7，1： | 2 |
| 10 | Tensile creep behavior of heat-treated TC11 titanium alloy at 450–550<ce:hsp sp='0.25'/>°C显示文摘 | Yi Gu Fanhao Zeng Yanling Qi Changqing Xia Xiang Xiong | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 11 | MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways显示文摘 | Longlong Bao Yan Yan Can Xu Weidan Ji Shuwen Shen Gaoya Xu Yong Zeng Bin Sun Haihua Qian Lei Chen Mengchao Wu Changqing Su Jie Chen | 2013 | Cancer Letters2013，，2： | 1 |
| 12 | CENP-G: a new centromeric protein that is associated with the α-1 satellite DNA subfamily显示文摘 | Dacheng He Changqing Zeng Karen Woods Ling Zhong Donna Turner Rose K. Busch Bill R. Brinkley Harris Busch | 1998 | Chromosoma1998，，3： | 1 |
| 13 | Graphenemodified carbon fiber microelectrode for the detection of dopamine in mice hippocampus tissue显示文摘 | ZHU Mingfang ZENG Changqing YE Jianshan | 2011 | Electroanalysis2011，23，4： | 1 |
| 14 | CENP-G: a new centromeric protein that is associated with the α-1 satellite DNA subfamily显示文摘 | Dacheng He Changqing Zeng Karen Woods Ling Zhong Donna Turner Rose K. Busch Bill R. Brinkley Harris Busch | 1998 | Chromosoma1998，，3： | 1 |
| 15 | An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC) has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional samples using Sanger sequencing. Whole-genome SNP arrays were employed to detect copy number alteration(CNA) and loss of heterozygosity(LOH) in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations(NSSMs) in102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology(GO) analysis. Tumor genomes with TP53 mutations were significantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B(30.9%), amplification of 11q13.3 covering CCND1(30.9%), and TP53 point mutation(50.9%) occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC.Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p11.2, and 3p12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes.These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting. | Qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 1 |
| 16 | The isothermal section of the Al-4Mg-Sc-Zr quaternary system in Al-rich range显示文摘 | Zeng Fanhao Xia Changqing Gu Yi | 2004 | Journal of Alloys and Compounds2004，363，： | 1 |
| 17 | Elevated plasma big ET-1 is associated with distant failure in patients with advanced-stage nasopharyngeal carcinoma 显示文摘 | HAI-QIANG MAI ZONC-YUAN ZENG CHANGQING ZHANG | 2006 | Cancer2006，106，： | 1 |
| 18 | CENP-G: a new centromeric protein that is associated with the α-1 satellite DNA subfamily显示文摘 | Dacheng He Changqing Zeng Karen Woods Ling Zhong Donna Turner Rose K. Busch Bill R. Brinkley Harris Busch | 1998 | Chromosoma1998，，3： | 1 |
| 19 | In vitro Transcriptome Analysis of Two Chinese Isolates of Streptococcus suis Serotype 2显示文摘The Streptococcus suis serotype 2(S. suis 2) isolates 05ZYH33 and 98HAH33 have caused severe human infections in China. Using a strand-specific RNA-seq analysis, we compared the in vitro transcriptomes of these two Chinese isolates with that of a reference strain(P1/7). In the89 K genomic island that is specific to these Chinese isolates, a toxin–antitoxin system showed relatively high levels of transcription among the S. suis. The known virulence factors with high transcriptional activity in these two highly-pathogenic strains are mainly involved in adhesion, biofilm formation, hemolysis and the synthesis and transport of the outer membrane protein. Furthermore,our analysis of novel transcripts identified over 50 protein-coding genes with one of them encoding a toxin protein. We also predicted over 30 small RNAs(s RNAs) in each strain, and most of them are involved in riboswitches. We found that six s RNA candidates that are related to bacterial virulence, including csp A and rli38, are specific to Chinese isolates. These results provide insight into the factors responsible for the difference in virulence among the different S. suis 2 isolates. | Dake Zhang Nan Du Sufang Ma Qingtao Hu Guangwen Lu Wei Chen Changqing Zeng | 2014 | Genomics, Proteomics & Bioinformatics2014，12，6： | 1 |
| 20 | CENP-G: a new centromeric protein that is associated with the α-1 satellite DNA subfamily显示文摘 | Dacheng He Changqing Zeng Karen Woods Ling Zhong Donna Turner Rose K. Busch Bill R. Brinkley Harris Busch | 1998 | Chromosoma1998，，3： | 1 |
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