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| 1 | Investigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study显示文摘Advancements in diagnostic systems for metastatic cancer over the last few decades have played a significant role in providing patients with effective treatment by evaluating the characteristics of cancer cells.Despite the progress made in cancer prognosis,we still rely on the visual analysis of tissues or cells from histopathologists,where the subjectivity of traditional manual interpretation persists.This paper presents the development of a dual diagnosis and treatment tool using an in vitro acoustic tweezers platform with a 50MHz ultrasonic transducer for label-free trapping and bursting of human breast cancer cells.For cancer cell detection and classification,the mechanical properties of a single cancer cell were quantified by single-beam acoustic tweezers(SBAT),a noncontact assessment tool using a focused acoustic beam.Cell-mimicking phantoms and agarose hydrogel spheres(AHSs)served to standardize the biomechanical characteristics of the cells.Based on the analytical comparison of deformability levels between the cells and the AHSs,the mechanical properties of the cells could be indirectly measured by interpolating the Young’s moduli of the AHSs.As a result,the calculated Young’s moduli,i.e.,1.527kPa for MDA-MB-231(highly invasive breast cancer cells),2.650kPa for MCF-7(weakly invasive breast cancer cells),and 2.772 kPa for SKBR-3(weakly invasive breast cancer cells),indicate that highly invasive cancer cells exhibited a lower Young’s moduli than weakly invasive cells,which indicates a higher deformability of highly invasive cancer cells,leading to a higher metastasis rate.Single-cell treatment may also be carried out by bursting a highly invasive cell with high-intensity,focused ultrasound. | Hae Gyun Lim Hsiao-Chuan Liu Chi Woo Yoon Hayong Jung Min Gon Kim Changhan Yoon Hyung Ham Kim KKirk Shung | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 2 | Enhanced activity ofGABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum 显示文摘 | Changhan OY Lianjun G Qing L etal | 2007 | Neuroscience Letters2007，420，2： | 1 |
| 3 | TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: Crosstalk between NF-κB and PPAR-γ显示文摘 | Youzhi Zhang Xiaoyan Yang Fang Bian Pinhui Wu Shasha Xing Gao Xu Wenjing Li Jiangyang Chi Changhan Ouyang Tao Zheng Dan Wu Yonghui Zhang Yongsheng Li Si Jin | 2014 | Journal of Molecular and Cellular Cardiology2014，，： | 1 |
| 4 | Enhancement of photoacoustic image quality by sound speed correction: ex viw evaluation显示文摘 | Changhan Yoon Jeeun Kang Yartgmo Yoo | 2012 | Optics Express2012，20，3： | 1 |
| 5 | Design and fabrication of acoustic wave actuated microgenerator for portable electronic devices显示文摘 | LAI Tenghsien HUANG Changhan TSOU Chingfu | 2008 | Design Test Integration and Packaging of MEMS/MOEM-S2008，9，11： | 1 |
| 6 | lncRInter:A database of experimentally validated long non-coding RNA interaction显示文摘Non-coding regions are the major component of human genomes and the long non-coding RNA(IncRNA)is a class of pervasive genes located in noncoding regions(Morris and Mattick,2014).IncRNAs play a wide range of regulatory roles in gene transcription,translation,epigenetic modification and protein function by interacting with different types of molecules including DNA,RNA | Chun-Jie Liu Changhan Gao Zhaowu Ma Renhuai Cong Qiong Zhang An-Yuan Guo | 2017 | Journal of Genetics and Genomics2017，44，5： | 0 |
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