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| 1 | Investigation into the flotation response of refractory molybdenum ore to depressant mixtures:A case study显示文摘In this paper, bulk flotation followed by separation was investigated to concentrate purified molybdenite product from Jinduicheng molybdenum ores(Shanxi province, China). The bench scale tests mainly focussed on separation of molybdenite from other sulfide minerals using the new type of depressants.The effect of each single depressant, including organic depressant-modified dextrin(MD), P-Nokes reagent(PN) and sodium trithiocarbonate(ST), and their mixtures on galena, chalcopyrite and other sulfide ores, was examined in turn by changing the concentrations used in cleaner flotation tests. Closed circuit experiments were carried out under the optimal condition and satisfying recovery and grade of molybdenite concentrate could be achieved(86.294% and 53.157%, respectively). A potential reagent regime was developed, with more environmental friendly and more economical advantages due to the introduction of modified dextrin. | Yin Zhigang Sun Wei Liu Jiandong Hu Yuehua Guan Qingjun Zhang Chenhu Tang Honghu Guan Changping | 2016 | International Journal of Mining Science and Technology2016，26，6： | 4 |
| 2 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 3 | N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA显示文摘Background:N-acetyltransferase 10(NAT10)is the only enzyme known tomediate the N4-acetylcytidine(ac4C)modification of mRNA and is crucial formRNA stability and translation efficiency.However,its role in cancer development and prognosis has not yet been explored.This study aimed to examine the possible role of NAT10 in colon cancer.Methods:The expression levels ofNAT10were evaluated by immunohistochemical analyses with a colon cancer tissue microarray,and its prognostic value in patients was further analyzed.Quantitative real-time polymerase chain reaction(qRT-PCR)and Western blotting were performed to analyze NAT10 expression in harvested colon cancer tissues and cell lines.Stable NAT10-knockdown and NAT10-overexpressing colon cancer cell lines were constructed using lentivirus.The biological functions of NAT10 in colon cancer cell lines were analyzed in vitro by Cell Counting Kit-8(CCK-8),wound healing,Transwell,cell cycle,and ferroptosis assays.Xenograft models were used to analyze the effect of NAT10 on the tumorigenesis and metastasis of colon cancer cells in vivo.Dot blotting,acetylated RNA immunoprecipitation-qPCR,and RNA stability analyses were performed to explore the mechanism by which NAT10 functions in colon cancer progression.Results:NAT10 was upregulated in colon cancer tissues and various colon cancer cell lines.This increased NAT10 expression was associated with shorter patient survival.Knockdown of NAT10 in two colon cancer cell lines(HT-29 and LoVo)impaired the proliferation,migration,invasion,tumor formation and metastasis of these cells,whereas overexpression of NAT10 promoted these abilities.Further analysis revealed that NAT10 exerted a strong effect on the mRNA stability and expression of ferroptosis suppressor protein 1(FSP1)in HT-29 and LoVo cells.In these cells,FSP1 mRNA was found to be modified by ac4C acetylation,and this epigenetic modification was associated with the inhibition of ferroptosis.Conclusions:Our study revealed that NAT10 plays a critical role in colon cancer development by affecting FSP1 mRNA stability and ferroptosis,suggesting that NAT10 could be a novel prognostic and therapeutic target in colon cancer. | Xiao Zheng Qi Wang You Zhou Dachuan Zhang Yiting Geng Wenwei Hu Changping Wu Yufang Shi Jingting Jiang | 2022 | Cancer Communications2022，42，12： | 3 |
| 4 | A study on service quality evaluation of digital libraries in China based on tetra-class model显示文摘Purpose: This study intends to evaluate the service quality of academic digital libraries(DLs)in China. By utilizing tetra-class model which concentrates on categorizing services according to their contributions to user satisfaction, this paper attempts to visually categorize the specific DL service elements to reveal their present performances, and then further explain the categorizing variations among different groups of users to discover the user preference.Design/methodology/approach: This paper carries out a survey to evaluate user experience on 27 typical DL services summarized from our investigations of representative Chinese university DLs. Based on the five-point Likert-type scale evaluation, the users' attitudes toward specific service element are divided into negative and positive dimensions. Afterwards,a correspondence analysis is applied to calculate the contributions to satisfaction and dissatisfaction of each service element based on tetra-class model. As a result, the DL service elements of Chinese academic libraries are classified into four categories(i.e. Basic, Secondary,Plus, and Key). Finally, we compared the categorizing variations.Findings: The results show that the DL service elements of Chinese academic libraries are all distributed in Basic and Key services regarding information retrieval and informationorganizing; 80% of the interaction services elements are Plus services, while 50% of the Secondary services are information-providing services. The results also reveal that service categorization is obviously influenced by the users' education background, especially their disciplines. Furthermore, the users who are older, more highly-educated, or studying in higher reputation universities are more likely to evaluate DL services as either critical or useless.Research limitations: Tetra-class model cannot reveal the interplay among the DL service elements. In addition, the user segmentation in our studies is limited to the sample structure.Practical implications: This empirical study focuses on the evaluation of DL services of academic libraries in China, the analyses of their current performances could provide useful reference for the assessment of other types of Chinese DLs. Moreover, the consideration of user characteristics(gender, age, and education background, etc.) in the DL evaluation would help librarians improve DL services to meet the users' various needs in teaching and doing scientific research.Originality/value: Different from the frequently-used factor analysis which focuses on the relationship among factors and user satisfaction, this paper tries to use and compare element distributions of different user segments while focusing on various service objectives. Factor analysis shows some flaws as used to measure the element with selected indicators, for it ignores the fact that the indicators which measure the same factor would have different degrees of impacts on user satisfaction. However, the tetra-class model can better visually analyze the performance of each DL service element from its contributions to satisfaction and dissatisfaction, which would help librarians to better understand users' need and offer DL services more efficiently. | Changping HU Weiwei YAN Yuan HU | 2013 | Chinese Journal of Library and Information Science2013，，2： | 2 |
| 5 | Horizontal and vertical gene transfer drive sediment antibiotic resistome in an urban lagoon system显示文摘Rapid urbanization has resulted in pervasive occurrence of antibiotic resistance genes(ARGs)in urban aquatic ecosystems.However,limited information is available concerning the ARG profiles and the forces responsible for their assembly in urban landscape lagoon systems.Here,we employed high-throughput quantitative PCR(HT-q PCR)to characterize the spatial variations of ARGs in surface and core sediments of Yundang Lagoon,China.The results indicated that the average richness and absolute abundance of ARGs were 11 and 53 times higher in the lagoon sediments as compared to pristine reference Tibetan lake sediments,highlighting the role of anthropogenic activities in ARG pollution.Co-occurrence network analysis indicated that various anaerobic prokaryotic genera belonging to Alpha-,Deltaproteobacteria,Bacteroidetes,Euryarchaeota,Firmicutes and Synergistetes were the potential hosts of ARGs.The partial least squares-path modeling(PLS-PM)analysis revealed positive and negative indirect effects of physicochemical factors and heavy metals on the lagoon ARG profiles,via biotic factors,respectively.The horizontal(mediated by mobile genetic elements)and vertical(mediated by prokaryotic communities)gene transfer may directly contribute the most to drive the abundance and composition of ARGs,respectively.Furthermore,the neutral community model demonstrated that the assembly of sediment ARG communities was jointly governed by deterministic and stochastic processes.Overall,this study provides novel insights into the diversity and distribution of ARGs in the benthic habitat of urban lagoon systems and underlying mechanisms for the spread and proliferation of ARGs. | Hongjie Wang Liyuan Hou Yongqin Liu Keshao Liu Lanping Zhang Fuyi Huang Lin Wang Azhar Rashid Anyi Hu Changping Yu | 2021 | Journal of Environmental Sciences2021，33，4： | 2 |
| 6 | Effects of Si addition on microstructure and mechanical properties of Mg–8Gd–4Y–Nd–Zr alloy显示文摘 | Xinming Zhang Jilong Hu Lingying Ye Yunlai Deng Changping Tang Liu Yang Zhaoyang Liu | 2013 | Materials and Design2013，，： | 1 |
| 7 | Protective effect of selaginellin on glutamate-induced cytotoxicity and apoptosis in differentiated PC 12 cells 显示文摘 | Wang Chenjing Hu Changping Xu Kangping | 2010 | Naunyn-Schmied Arch Pharmacol2010，381，： | 1 |
| 8 | Effects of Selaginellin on Homocysteine-Induced Senescence in Human Umbilical Vein Endothelial Cells 显示文摘 | Wang Chenjing Hu Changping Xu Kangping | 2010 | J Cardiovasc Pharmacol2010，55，6： | 1 |
| 9 | Identifying the research fo- cus of library and information science institutions in china with institu- tion-specific keywords 显示文摘 | Chen Guo Xiao Lu Hu Changping | 2015 | Scientometrics2015，103，3： | 1 |
| 10 | Modification of Mg2Si in Mg-Si alloys with gadolinium显示文摘 | Ye Lingying Hu Jilong Tang Changping | 2013 | Materials Characterization2013，79，： | 1 |
| 11 | Resveratrol derivative BTM-0512 mitigates obesity by promoting beige remodeling of subcutaneous preadipocytes显示文摘 | Qingqing Li Kuansong Wang Yipeng Ma Chunxiang Qin Changsheng Dong Ping Jin Yan Wu Xiaoming Xiong Niansheng Li Changping Hu Jun Peng Zhichun Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 1 |
| 12 | Adaptive synchronization of uncertain R~ssler hyperchaotic system based on parameter identifieation显示文摘 | Chert Shihua Hu Ja Wang Changping | 2004 | Physies Letters A2004，321，： | 1 |
| 13 | An empirical study of factors influencing user perception of university digital librar- ies in China 显示文摘 | HU Changping HU Yuan YAN Weiwei | 2014 | Library & Information Science Research2014，36，34： | 1 |
| 14 | Factors influencing user adoption of location based service:From the expanded TAM perspective显示文摘Purpose:This study intends to examine the factors influencing user adoption of location based service(LBS).Design/methodology/approach:This paper develops the research model for user adoption of LBS with the technology acceptance model(TAM) as the theoretical foundation.Using a questionnaire and sampling method,empirical data was collected from 386 participants.Structured equation modeling was used to test the validity of the proposed model.Findings:The results show that I) perceived ease of use.perceived usefulness and perceived playfulness were direct determinants of behavioral intention,and perceived ease of use has the greatest impact of the three;2) emergency,ubiquity,technology maturity and social trust all have positive and significant impacts on perceived ease of use;3) emergency and social trust significantly influence perceived usefulness positively:4) individualization and social impact significantly affect perceived playfulness positively.Research limitations:Subjects were from China's Mainland,which limits the generalizability of the research findings.The interaction effects of age,gender and user experience were not included.Practical implications:This study offers LBS operators,marketers and application developers insights into the way to attract more users by increasing perceived usefulness,ease of use and playfulness of LBS.Originality/value:Location based service is still a relatively new concept and there were few theoretical and empirical studies that examine user adoption of the serv ice.This study contributes to existing LBS adoption studies by modifying and extending TAM and meanwhile the empirical study will help the research community gain a deeper understanding of the factors affecting user adoption of LBS. | Yuan HU Changping HU Jin HU | 2014 | Chinese Journal of Library and Information Science2014，，2： | 0 |
| 15 | An analysis of user interactive learning behavior in academic library information commons in China显示文摘This study explores the influencing factors of user interactive learning behavior in academic library information commons,by extending the original Technology Acceptance Model.The hypothesized relationships were tested via structural equation modeling,combining the specific context of academic library information commons.The results show that:a) Perceived usefulness,perceived ease of use,and perceived encouragement are the direct influencing factors;b) Perceived ease of use and perceived encouragement can directly affect perceived usefulness;c) User characteristic,social identity,service content affect user interactive learning behavior via perceived encouragement and perceived ease of use;d) Service ability can affect user interactive learning behavior via perceived encouragement. | Changping HU Yuan HU | 2014 | Journal of Library Science in China2014，，1： | 0 |
| 16 | Nanomedicine-based treatment:An emerging therapeutical strategy for pulmonary hypertension显示文摘Pulmonary hypertension(PH)can cause breathing difficulty,a rapid decline of exercise capacity,heart failure,eventually death of the patients.The latest epidemiological study demonstrates that PH has a much higher incidence than previously thought.PH is still a highly fatal disease due to the many disadvantages of the current drugs,such as short half-life,lack of targeting,potent side effects.The PH pathological features offer great opportunities for nanomedicines for PH.Recently,emerging nanomedicines demonstrated great advantages in the therapeutic effect of PH by enhancing the accumulation of drugs in PH lesion,optimizing drug efficacy,minimizing drug side effects.However,this promising field of cross-cutting research is far from being widely explored due to the huge professional barriers.To solve this problem,we provide a comprehensive review for the latest progresses of nanomedicines in the treatment of PH.Firstly,we systematical summarized the PH pathological features and the current clinical drug treatment of PH.The advantages of nanomedicines are also deeply discussed in the treatment of PH.Subsequently,we focused on the research progresses of nanomedicines in PH through three aspects:advanced nano-drug delivery system for traditional drugs and new target drugs,gene therapy-based nanomedicines,other nanomedicines for the treatment of PH.Finally,we also discussed the prospects and challenges for the clinical application of nanomedicines in PH,provided directions for the research and development of nanomedicines for PH treatment in the future. | Shuya Wang Qiaohui Chen Tianjiao Zhao Kelong Ai Changping Hu | 2023 | Nano Research2023，16，5： | 0 |
| 17 | Removal and utilization of calcite existed in scheelite by preparation of calcium sulfate whiskers显示文摘In order to eliminate the effect of calcite associated with scheelite on the scheelite flotation, hydrochloric acid was used to dissolve the calcite, and the soaking solution was used to prepare CaSO_4 whiskers by hydrothermal reaction with sulfuric acid at ambient pressure. First, the condition experiments of preparing CaSO_4 whiskers by using CaCl_2 and H_2SO_4 were carried out to optimize reaction parameters of the crystallization process. The optimal conditions were: at 102 ℃ reaction temperature, 0,5 mol/L reactant concentration and 60 min reaction time. Then based on the condition experiments and considering keeping acid concentration stable for achieving HCl recycling, Calcium sulfate whiskers with the average diameter of 1.41 μm and the average aspect ratio of 109 were prepared by the soaking solution after evaporating to half of its volume and 1.0 mol/L H_2SO_4 at 102 ℃ for 60 min: After ion exchange processing,the filtrate could be used as HCl in the process of HCl dissolution. | Guan Qingjun Sun Wei Hu Yuehua Guan Changping Yin Zhigang Zhang Chenhu | 2017 | International Journal of Mining Science and Technology2017，27，6： | 0 |
| 18 | Socialization group based information aggregation services显示文摘Information aggregation services improve to a certain extent the efficiency and quality of how users obtain information.However,the ever-increasing 'fragmented' information distracts people’s attention.Pure information aggregation services can no longer effectively control the quality of information and satisfy users’ socialized information needs.On the basis of analyzing the existing socialized information recommendation aggregation and combined with the effect of socialization group,we construct the socialization group effect based information recommendation aggregation service model.In addition, 'Wanju-SR' is taken as an example to illustrate the model’s realization strategy.This research indicates that,since socialized recommendation aggregation services can effectively increase the accuracy of information recommendation,it will become an effective way for mining valuable information in the online environment. | HU Changping HU Jiming DENG Shengli | 2011 | Journal of Library Science in China2011，，1： | 0 |
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